8054期

最新文章

• For more reliable AI, academics should edit Wikipedia AI翻译
  作者：Finney, Declan; Baleta, Tatjana
  作者单位：University of Leeds
• The 'quantum' principle that says why atoms are as they are AI翻译
  作者：Freire Jr, Olival; Hartz, Thiago
  作者单位：Universidade Federal da Bahia; Universidade Federal do Rio de Janeiro
• Private spacecraft nails Moon landing: first images of Blue Ghost on the lunar surface AI翻译
  作者：Witze, Alexandra
  摘要：The touchdown is a much-needed win for NASA's partnerships with commercial space companies.
• Genetic architecture in Greenland is shaped by demography, structure and selection AI翻译
  作者：Staeger, Frederik Filip; Andersen, Mette K.; Li, Zilong; Hjerresen, Jasmin Pernille; He, Shixu; Santander, Cindy G.; Jensen, Rasmus Tanderup; Rex, Karsten Fleischer; Thuesen, Anne Cathrine Baun; Hanghoj, Kristian; Seiding, Inge Host; Jorsboe, Emil; Stinson, Sara Elizabeth; Rasmussen, Malthe Sebro; Balboa, Renzo F.; Larsen, Christina Viskum Lytken; Bjerregaard, Peter; Schubert, Mikkel; Meisner, Jonas; Linneberg, Allan; Grarup, Niels; Zeggini, Eleftheria; Nielsen, Rasmus; Jorgensen, Marit E.; Hansen, Torben; Moltke, Ida; Albrechtsen, Anders
  作者单位：University of Copenhagen; University of Copenhagen; Aalborg University; Aalborg University Hospital; University of Oxford; University of Oxford; University of Southern Denmark; University of Copenhagen; Bispebjerg Hospital; Copenhagen University Hospital; University of Copenhagen; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Technical University of Munich; Technical University of Munich; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of Copenhagen
  摘要：Greenlandic Inuit and other indigenous populations are underrepresented in genetic research1,2, leading to inequity in healthcare opportunities. To address this, we performed analyses of sequenced or imputed genomes of 5,996 Greenlanders with extensive phenotypes. We quantified their historical population bottleneck and how it has shaped their genetic architecture to have fewer, but more common, variable sites. Consequently, we find twice as many high-impact genome-wide associations to metabol...
• HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes (vol 623, pg 1026, 2023) AI翻译
  作者：Li, Wenwei; Qin, Zhuan; Nand, Elizabeth; Grunst, Michael W.; Grover, Jonathan R.; Bess, Julian W.; Lifson, Jeffrey D.; Zwick, Michael B.; Tagare, Hemant D.; Uchil, Pradeep D.; Mothes, Walther
• Engineered heart muscle allografts for heart repair in primates and humans AI翻译
  作者：Jebran, Ahmad-Fawad; Seidler, Tim; Tiburcy, Malte; Daskalaki, Maria; Kutschka, Ingo; Fujita, Buntaro; Ensminger, Stephan; Bremmer, Felix; Moussavi, Amir; Yang, Huaxiao; Qin, Xulei; Missbach, Sophie; Drummer, Charis; Baraki, Hassina; Boretius, Susann; Hasenauer, Christopher; Nette, Tobias; Kowallick, Johannes; Ritter, Christian O.; Lotz, Joachim; Didie, Michael; Mietsch, Mathias; Meyer, Tim; Kensah, George; Krueger, Dennis; Sakib, Md Sadman; Kaurani, Lalit; Fischer, Andre; Dressel, Ralf; Rodriguez-Polo, Ignacio; Stauske, Michael; Diecke, Sebastian; Maetz-Rensing, Kerstin; Gruber-Dujardin, Eva; Bleyer, Martina; Petersen, Beatrix; Roos, Christian; Zhang, Liye; Walter, Lutz; Kaulfuss, Silke; Yigit, Goekhan; Wollnik, Bernd; Levent, Elif; Roshani, Berit; Stahl-Henning, Christiane; Stroebel, Philipp; Legler, Tobias; Riggert, Joachim; Hellenkamp, Kristian; Voigt, Jens-Uwe; Hasenfuss, Gerd; Hinkel, Rabea; Wu, Joseph C.; Behr, Ruediger; Zimmermann, Wolfram-Hubertus
  作者单位：University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; German Centre for Cardiovascular Research; University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; Justus Liebig University Giessen; University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; Leibniz Association; Deutsches Primatenzentrum (DPZ); University of Kiel; Schleswig Holstein University Hospital; German Centre for Cardiovascular Research; University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; Leibniz Association; Deutsches Primatenzentrum (DPZ); Stanford University; Stanford University; Leibniz Association; Deutsches Primatenzentrum (DPZ); University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; Helmholtz Association; German Center for Neurodegenerative Diseases (DZNE); University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; University of Gottingen; University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; Helmholtz Association; Max Delbruck Center for Molecular Medicine; German Centre for Cardiovascular Research; Leibniz Association; Deutsches Primatenzentrum (DPZ); Leibniz Association; Deutsches Primatenzentrum (DPZ); University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; Leibniz Association; Deutsches Primatenzentrum (DPZ); University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; KU Leuven; KU Leuven; University Hospital Leuven; Helmholtz Association; German Center for Neurodegenerative Diseases (DZNE)
  摘要：Cardiomyocytes can be implanted to remuscularize the failing heart1, 2, 3, 4, 5, 6-7. Challenges include sufficient cardiomyocyte retention for a sustainable therapeutic impact without intolerable side effects, such as arrhythmia and tumour growth. We investigated the hypothesis that epicardial engineered heart muscle (EHM) allografts from induced pluripotent stem cell-derived cardiomyocytes and stromal cells structurally and functionally remuscularize the chronically failing heart without lim...
• Individual variability of neural computations underlying flexible decisions AI翻译
  作者：Pagan, Marino; Tang, Vincent D.; Aoi, Mikio C.; Pillow, Jonathan W.; Mante, Valerio; Sussillo, David; Brody, Carlos D.
  作者单位：University of Edinburgh; University of California System; University of California San Diego; University of Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; Stanford University; Stanford University; Howard Hughes Medical Institute
  摘要：The ability to flexibly switch our responses to external stimuli according to contextual information is critical for successful interactions with a complex world. Context-dependent computations are necessary across many domains1, 2-3, yet their neural implementations remain poorly understood. Here we developed a novel behavioural task in rats to study context-dependent selection and accumulation of evidence for decision-making4, 5-6. Under assumptions supported by both monkey and rat data, we ...
• The genetic origin of the Indo-Europeans (Feb, 10.1038/s41586-024-08531-5, 2025) AI翻译
  作者：Lazaridis, Iosif; Patterson, Nick; Anthony, David; Vyazov, Leonid; Fournier, Romain; Ringbauer, Harald; Olalde, Inigo; Khokhlov, Alexander A.; Kitov, Egor P.; Shishlina, Natalia I.; Ailincai, Sorin C.; Agapov, Danila S.; Agapov, Sergey A.; Batieva, Elena; Bauyrzhan, Baitanayev; Bereczki, Zsolt; Buzhilova, Alexandra; Changmai, Piya; Chizhevsky, Andrey A.; Ciobanu, Ion; Constantinescu, Mihai; Csanyi, Marietta; Dani, Janos; Dashkovskiy, Peter K.; Evinger, Sandor; Faifert, Anatoly; Flegontov, Pavel; Frinculeasa, Alin; Frinculeasa, Madalina N.; Hajdu, Tamas; Higham, Tom; Jarosz, Pawel; Jelinek, Pavol; Khartanovich, Valeri I.; Kirginekov, Eduard N.; Kiss, Viktoria; Kitova, Alexandera; Kiyashko, Alexeiy V.; Koledin, Jovan; Korolev, Arkady; Kosintsev, Pavel; Kulcsar, Gabriella; Kuznetsov, Pavel; Magomedov, Rabadan; Mamedov, Aslan M.; Melis, Eszter; Moiseyev, Vyacheslav; Molnar, Erika; Monge, Janet; Negrea, Octav; Nikolaeva, Nadezhda A.; Novak, Mario; Ochir-Goryaeva, Maria; Palfi, Gyoergy; Popovici, Sergiu; Rykun, Marina P.; Savenkova, Tatyana M.; Semibratov, Vladimir P.; Seregin, Nikolai N.; Sefcakova, Alena; Mussayeva, Raikhan S.; Shingiray, Irina; Shirokov, Vladimir N.; Simalcsik, Angela; Sirak, Kendra; Solodovnikov, Konstantin N.; Tarnoki, Judit; Tishkin, Alexey A.; Trifonov, Viktor; Vasilyev, Sergey; Akbari, Ali; Brielle, Esther S.; Callan, Kim; Candilio, Francesca; Cheronet, Olivia; Curtis, Elizabeth; Flegontova, Olga; Iliev, Lora; Kearns, Aisling; Keating, Denise; Lawson, Ann Marie; Mah, Matthew; Micco, Adam; Michel, Megan; Oppenheimer, Jonas; Qiu, Lijun; Workman, J. Noah; Zalzala, Fatma; Szecsenyi-Nagy, Anna; Palamara, Pier Francesco; Mallick, Swapan; Rohland, Nadin; Pinhasi, Ron; Reich, David
• Activation and inhibition mechanisms of a plant helper NLR AI翻译
  作者：Xiao, Yinyan; Wu, Xiaoxian; Wang, Zaiqing; Ji, Kexin; Zhao, Yang; Zhang, Yu; Wan, Li
  作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS
  摘要：Plant nucleotide-binding leucine-rich repeat (NLR) receptors sense pathogen effectors and form resistosomes to confer immunity1. Some sensor NLR resistosomes produce small molecules to induce formation of a heterotrimer complex with two lipase-like proteins, EDS1 and SAG101, and a helper NLR called NRG1 (refs. 2,3). Activation of sensor NLR resistosomes also triggers NRG1 oligomerization and resistosome formation at the plasma membrane4,5. We demonstrate that the Arabidopsis AtEDS1-AtSAG101-At...
• How a vast digital twin of the Yangtze River could prevent flooding in China AI翻译
  作者：Wang, Xiaopeng; Wu, Biqiong; Zhou, Guoliang; Wang, Tao; Meng, Fanwei; Zhou, Li; Cao, Hui; Tang, Zhengyang
  作者单位：China Three Gorges University; China University of Mining & Technology; Sichuan University
  摘要：A project that intertwines data on weather, water flow and energy demand to create a 3D model of the whole river basin would enable researchers and others to make water-management decisions in real time.