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作者：Braun, David A.; Moranzoni, Giorgia; Chea, Vipheaviny; Mcgregor, Bradley A.; Blass, Eryn; Tu, Chloe R.; Vanasse, Allison P.; Forman, Cleo; Forman, Juliet; Afeyan, Alexander B.; Schindler, Nicholas R.; Liu, Yiwen; Li, Shuqiang; Southard, Jackson; Chang, Steven L.; Hirsch, Michelle S.; Leboeuf, Nicole R.; Olive, Oriol; Mehndiratta, Ambica; Greenslade, Haley; Shetty, Keerthi; Klaeger, Susan; Sarkizova, Siranush; Pedersen, Christina B.; Mossanen, Matthew; Carulli, Isabel; Tarren, Anna; Duke-Cohan, Joseph; Howard, Alexis A.; Iorgulescu, J. Bryan; Shim, Bohoon; Simon, Jeremy M.; Signoretti, Sabina; Aster, Jon C.; Elagina, Liudmila; Carr, Steven A.; Leshchiner, Ignaty; Getz, Gad; Gabriel, Stacey; Hacohen, Nir; Olsen, Lars R.; Oliveira, Giacomo; Neuberg, Donna S.; Livak, Kenneth J.; Shukla, Sachet A.; Fritsch, Edward F.; Wu, Catherine J.; Keskin, Derin B.; Ott, Patrick A.; Choueiri, Toni K.
作者单位：Yale University; Yale University; Yale New Haven Hospital; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Technical University of Denmark; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Copenhagen; Copenhagen University Hospital; Rigshospitalet; Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Boston University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Boston University; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center
摘要：Personalized cancer vaccines (PCVs) can generate circulating immune responses against predicted neoantigens1, 2, 3, 4, 5-6. However, whether such responses can target cancer driver mutations, lead to immune recognition of a patient's tumour and result in clinical activity are largely unknown. These questions are of particular interest for patients who have tumours with a low mutational burden. Here we conducted a phase I trial (ClinicalTrials.gov identifier NCT02950766) to test a neoantigen-ta...
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作者：Reina-Campos, Miguel; Monell, Alexander; Ferry, Amir; Luna, Vida; Cheung, Kitty P.; Galletti, Giovanni; Scharping, Nicole E.; Takehara, Kennidy K.; Quon, Sara; Challita, Peter P.; Boland, Brigid; Lin, Yun Hsuan; Wong, William H.; Indralingam, Cynthia S.; Neadeau, Hayley; Alarcon, Suzie; Yeo, Gene W.; Chang, John T.; Heeg, Maximilian; Goldrath, Ananda W.
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA San Diego Healthcare System
摘要：Tissue-resident memory CD8 T (TRM) cells provide protection from infection at barrier sites. In the small intestine, TRM cells are found in at least two distinct subpopulations: one with higher expression of effector molecules and another with greater memory potential1. However, the origins of this diversity remain unknown. Here we proposed that distinct tissue niches drive the phenotypic heterogeneity of TRM cells. To test this, we leveraged spatial transcriptomics of human samples, a mouse m...
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作者：Botelho, Tristan L.; Jun, Sora; Humes, Demetrius; Decelles, Katherine A.
作者单位：Yale University; Rice University; University of Toronto
摘要：Online platforms are rife with racial discrimination1, but current interventions focus on employers2,3 rather than customers. We propose a customer-facing solution: changing to a two-point rating scale (dichotomization). Compared with the ubiquitous five-star scale, we argue that dichotomization reduces modern racial discrimination by focusing evaluators on the distinction between 'good' and 'bad' performance, thereby reducing how personal beliefs shape customer assessments. Study 1 is a quasi...
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作者：Agarwal, Vikram; Inoue, Fumitaka; Schubach, Max; Penzar, Dmitry; Martin, Beth K.; Dash, Pyaree Mohan; Keukeleire, Pia; Zhang, Zicong; Sohota, Ajuni; Zhao, Jingjing; Georgakopoulos-Soares, Ilias; Noble, William S.; Yardimci, Galip Gurkan; Kulakovskiy, Ivan V.; Kircher, Martin; Shendure, Jay; Ahituv, Nadav
作者单位：University of Washington; University of Washington Seattle; Sanofi-Aventis; Sanofi USA; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Kyoto University; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Russian Academy of Sciences; Vavilov Institute of General Genetics; Russian Academy of Sciences; Pirogov Russian National Research Medical University; University of Lubeck; University of Kiel; Schleswig Holstein University Hospital; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health; University of Washington; University of Washington Seattle; Oregon Health & Science University; Oregon Health & Science University; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle
摘要：The human genome contains millions of candidate cis-regulatory elements (cCREs) with cell-type-specific activities that shape both health and many disease states1. However, we lack a functional understanding of the sequence features that control the activity and cell-type-specific features of these cCREs. Here we used lentivirus-based massively parallel reporter assays (lentiMPRAs) to test the regulatory activity of more than 680,000 sequences, representing an extensive set of annotated cCREs ...
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作者：Mallapaty, Smriti
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作者：Zhang, X.
