8059期

最新文章

• How the United States became a science superpower - and how quickly it could crumble AI翻译
  作者：Blank, Steve
  作者单位：Stanford University
• Faster, cheaper, better: the rise of blood tests for Alzheimer's AI翻译
  作者：Dolgin, Elie
• Ensuring that conferences are inclusive requires diverse organizers AI翻译
  作者：Joaquin, Jeremiah Joven; Biana, Hazel T.
  作者单位：De La Salle University
• Don't rush promising stem-cell therapies AI翻译
  作者：[Anonymous]
• Observation of plastic ice VII by quasi-elastic neutron scattering AI翻译
  作者：Rescigno, Maria; Toffano, Alberto; Ranieri, Umbertoluca; Andriambariarijaona, Leon; Gaal, Richard; Klotz, Stefan; Koza, Michael Marek; Ollivier, Jacques; Martelli, Fausto; Russo, John; Sciortino, Francesco; Teixeira, Jose; Bove, Livia Eleonora
  作者单位：Sapienza University Rome; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Bristol; University of Edinburgh; University of Edinburgh; Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Sorbonne Universite; CNRS - Institute of Physics (INP); Institut Laue-Langevin (ILL); University of Manchester; CEA; Centre National de la Recherche Scientifique (CNRS); University of Basque Country
  摘要：Water is the third most abundant molecule in the universe and a key component in the interiors of icy moons, giant planets and Uranus- and Neptune-like exoplanets1, 2-3. Owing to its distinct molecular structure and flexible hydrogen bonds that readily adapt to a wide range of pressures and temperatures, water forms numerous crystalline and amorphous phases4, 5-6. Most relevant for the high pressures and temperatures of planetary interiors is ice VII (ref. 4), and simulations have identified a...
• Reply to: Natively expressed AcrIII-1 does not function as an anti-CRISPR protein AI翻译
  作者：Athukoralage, Januka S.; McMahon, Stephen A.; Zhang, Changyi; Grueschow, Sabine; Graham, Shirley; Krupovic, Mart; Whitaker, Rachel J.; Gloster, Tracey M.; White, Malcolm F.
  作者单位：University of St Andrews; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris
• Why women experience Alzheimer's disease differently from men AI翻译
  作者：Bourzac, Katherine
• Genome-coverage single-cell histone modifications for embryo lineage tracing AI翻译
  作者：Liu, Min; Yue, Yanzhu; Chen, Xubin; Xian, Kexin; Dong, Chao; Shi, Ming; Xiong, Haiqing; Tian, Kang; Li, Yuzhe; Zhang, Qiangfeng Cliff; He, Aibin
  作者单位：Peking University; Peking University; Peking University; Jilin University; Chinese Academy of Medical Sciences - Peking Union Medical College; Institute of Hematology & Blood Diseases Hospital - CAMS; Peking Union Medical College; Tsinghua University; Tsinghua University; Tsinghua University; Peking University; Peking University; Peking University
  摘要：Substantial epigenetic resetting during early embryo development from fertilization to blastocyst formation ensures zygotic genome activation and leads to progressive cellular heterogeneities1, 2-3. Mapping single-cell epigenomic profiles of core histone modifications that cover each individual cell is a fundamental goal in developmental biology. Here we develop target chromatin indexing and tagmentation (TACIT), a method that enabled genome-coverage single-cell profiling of seven histone modi...
• Precursors of exhausted T cells are pre-emptively formed in acute infection AI翻译
  作者：Chu, Talyn; Wu, Ming; Hoellbacher, Barbara; de Almeida, Gustavo P.; Wurmser, Christine; Berner, Jacqueline; Donhauser, Lara V.; Gerullis, Ann-Katrin; Lin, Siran; Cepeda-Mayorga, J. Diego; Kilb, Iman I.; Bongers, Lukas; Toppeta, Fabio; Strobl, Philipp; Youngblood, Ben; Schulz, Anna M.; Zippelius, Alfred; Knolle, Percy A.; Heinig, Matthias; Hackstein, Carl-Philipp; Zehn, Dietmar
  作者单位：Technical University of Munich; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Technical University of Munich; Technical University of Munich; Technical University of Munich; St Jude Children's Research Hospital; University of Basel; Technical University of Munich
  摘要：T cell exhaustion limits effector T cell function in chronic infection and tumours1,2. The development of these hypofunctional T cells and of their precursors was considered to require stimulatory conditions that are met only after persistent exposure to antigen and inflammation. Here we show, however, that similar T cell populations exist in the early phase of acute infections1,2. At that stage, the early developing TCF1+ precursor population exhibits an unexpected diversity; it includes prec...
• Isoprene nitrates drive new particle formation in Amazon's upper troposphere (vol 636, 124, 2024) AI翻译
  作者：Curtius, Joachim; Heinritzi, Martin; Beck, Lisa J.; Poehlker, Mira L.; Tripathi, Nidhi; Krumm, Bianca E.; Holzbeck, Philip; Nussbaumer, Clara M.; Pardo, Lianet Hernandez; Klimach, Thomas; Barmpounis, Konstantinos; Andersen, Simone T.; Bardakov, Roman; Bohn, Birger; Cecchini, Micael A.; Chaboureau, Jean-Pierre; Dauhut, Thibaut; Dienhart, Dirk; Doerich, Raphael; Edtbauer, Achim; Giez, Andreas; Hartmann, Antonia; Holanda, Bruna A.; Joppe, Philipp; Kaiser, Katharina; Keber, Timo; Klebach, Hannah; Krueger, Ovid O.; Kuerten, Andreas; Mallaun, Christian; Marno, Daniel; Martinez, Monica; Monteiro, Carolina; Nelson, Carolina; Ort, Linda; Raj, Subha S.; Richter, Sarah; Ringsdorf, Akima; Rocha, Fabio; Simon, Mario; Sreekumar, Sreedev; Tsokankunku, Anywhere; Unfer, Gabriela R.; Valenti, Isabella D.; Wang, Nijing; Zahn, Andreas; Zauner-Wieczorek, Marcel; Albrecht, Rachel I.; Andreae, Meinrat O.; Artaxo, Paulo; Crowley, John N.; Fischer, Horst; Harder, Hartwig; Herdies, Dirceu L.; Machado, Luiz A. T.; Poehlker, Christopher; Poeschl, Ulrich; Possner, Anna; Pozzer, Andrea; Schneider, Johannes; Williams, Jonathan; Lelieveld, Jos