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作者：Archer, Matthew; Wang, Jinbo; Klein, Patrice; Dibarboure, Gerald; Fu, Lee-Lueng
作者单位：California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); Texas A&M University System; Texas A&M University College Station; California Institute of Technology; Institut Polytechnique de Paris; Ecole Polytechnique; Sorbonne Universite; Ecole des Ponts ParisTech; Universite PSL; Ecole Normale Superieure (ENS)
摘要：Ocean submesoscale (1-100 km) processes and their substantial impact on Earth's climate system have been increasingly emphasized in recent decades by high-resolution numerical models and regional observations1, 2, 3, 4, 5, 6, 7, 8, 9, 10-11. However, the dynamics and energy associated with these processes, including submesoscale eddies and nonlinear internal waves, have never been observed from a global perspective. Where, when and how much do these submesoscale processes contribute to the lar...
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作者：Maji, Arun; Burke, Martin D.
作者单位：University of Kentucky; University of Illinois System; University of Illinois Urbana-Champaign
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作者：Fletcher Jr, Robert J.
作者单位：University of Cambridge
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作者：Zhi, Xiaofei; Wu, Feijing; Qian, Jin; Ochiai, Yosuke; Lian, Guodong; Malagola, Ermanno; Zheng, Biyun; Tu, Ruhong; Zeng, Yi; Kobayashi, Hiroki; Xia, Zhangchuan; Wang, Ruizhi; Peng, Yueqing; Shi, Qiongyu; Chen, Duan; Ryeom, Sandra W.; Wang, Timothy C.
作者单位：Columbia University; Nantong University; Fujian Medical University; Columbia University; NewYork-Presbyterian Hospital; Columbia University; Columbia University; Norwegian University of Science & Technology (NTNU); Columbia University; NewYork-Presbyterian Hospital
摘要：Cancer cells have been shown to exploit neurons to modulate their survival and growth, including through the establishment of neural circuits within the central nervous system1, 2-3. Here we report a distinct pattern of cancer-nerve interactions between the peripheral nervous system and gastric cancer. In multiple mouse models of gastric cancer, nociceptive nerves demonstrated the greatest degree of nerve expansion in an NGF-dependent manner. Neural tracing identified CGRP+ peptidergic neurons...
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作者：Meza, Arismel Tena; Rivera, Christina A.; Shao, Huiling; Kelleghan, Andrew V.; Houk, K. N.; Garg, Neil K.
作者单位：University of California System; University of California Los Angeles
摘要：The development of new synthetic methodologies is instrumental for enabling the discovery of new medicines. The methods that provide efficient access to structural alternatives for aromatic compounds (that is, saturated arene bioisosteres) have become highly coveted1, 2, 3-4. The incorporation of these bioisosteres typically leads to favourable drug-like properties and represents an emerging field of research. Here we report a new synthetic method that furnishes a coveted motif, the bicyclo[2....
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作者：Garisto, Dan
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作者：Hafner, Danijar; Pasukonis, Jurgis; Ba, Jimmy; Lillicrap, Timothy
作者单位：Alphabet Inc.; DeepMind; University of Toronto
摘要：Developing a general algorithm that learns to solve tasks across a wide range of applications has been a fundamental challenge in artificial intelligence. Although current reinforcement-learning algorithms can be readily applied to tasks similar to what they have been developed for, configuring them for new application domains requires substantial human expertise and experimentation(1,2). Here we present the third generation of Dreamer, a general algorithm that outperforms specialized methods ...
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作者：Perica, Karlo; Kotchetkov, Ivan S.; Mansilla-Soto, Jorge; Ehrich, Fiona; Herrera, Kevin; Shi, Yuzhe; Dobrin, Anton; Gonen, Mithat; Sadelain, Michel
作者单位：Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; H Lee Moffitt Cancer Center & Research Institute; Columbia University
摘要：Autologous chimeric antigen receptor (CAR) T cells are a genetically engineered therapy that is highly effective against B cell malignancies and multiple myeloma1. However, the length and cost of personalized manufacturing limits access and leaves patients vulnerable to disease progression. Allogeneic cell therapies have the potential to increase patient access and improve treatment outcomes but are limited by immune rejection2,3. To devise a strategy to protect allogeneic CAR T cells from hos...
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作者：Lanza, Mario; Pazos, Sebastian; Aguirre, Fernando; Sebastian, Abu; Le Gallo, Manuel; Alam, Syed M.; Ikegawa, Sumio; Yang, J. Joshua; Vianello, Elisa; Chang, Meng-Fan; Molas, Gabriel; Naveh, Ishai; Ielmini, Daniele; Liu, Ming; Roldan, Juan B.
作者单位：National University of Singapore; Institute for Functional Intelligent Materials (I-FIM); National University of Singapore; National University of Singapore; King Abdullah University of Science & Technology; International Business Machines (IBM); IBM Switzerland; University of Southern California; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); CEA; National Tsing Hua University; Polytechnic University of Milan; Chinese Academy of Sciences; Institute of Microelectronics, CAS; University of Granada
摘要：The semiconductor industry is experiencing an accelerated transformation to overcome the scaling limits of the transistor and to adapt to new requirements in terms of data storage and computation, especially driven by artificial intelligence applications and the Internet of Things. In this process, new materials, devices, integration strategies and system architectures are being developed and optimized. Among them, memristive devices and circuits-memristors are two-terminal memory devices that...
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作者：Chopra, Pradeep; Ray, Sean D.; Page, Caroline K.; Shepard, Justin D.; Kandeil, Ahmed; Jeevan, Trushar; Bowman, Andrew S.; Ellebedy, Ali H.; Webby, Richard J.; de Vries, Robert P.; Tompkins, S. Mark; Boons, Geert-Jan
作者单位：University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; St Jude Children's Research Hospital; University System of Ohio; Ohio State University; Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Utrecht University; University System of Georgia; University of Georgia
