作者：Deng, Qisen; Li, Yinchuan; He, Wenyan; Chen, Tao; Liu, Nan; Ma, Lingman; Qiu, Zhixia; Shang, Zhuo; Wang, Zongqiang
作者单位：China Pharmaceutical University; China Pharmaceutical University; China Pharmaceutical University; Shandong University
摘要：The global spread of multidrug-resistant pathogenic fungi presents a serious threat to human health, necessitating the discovery of antifungals with unique modes of action1. However, conventional activity-based screening for previously undescribed antibiotics has been hampered by the high-frequency rediscovery of known compounds and the lack of new antifungal targets2. Here we report the discovery of a polyene antifungal antibiotic, mandimycin, using a phylogeny-guided natural-product discover...
作者：Sau, Abhishek; Schnorrenberg, Sebastian; Huang, Ziqiang; Bandyopadhyay, Debolina; Sharma, Ankith; Guerth, Clara-Marie; Dave, Sandeep; Musser, Siegfried M.
作者单位：Texas A&M University System; Texas A&M University College Station; European Molecular Biology Laboratory (EMBL)
摘要：The nuclear pore complex (NPC) mediates nucleocytoplasmic exchange, catalysing a massive flux of protein and nucleic acid material in both directions1. Distinct trafficking pathways for import and export would be an elegant solution to avoid unproductive collisions and opposing movements. However, the three-dimensional (3D) nanoscale spatiotemporal dynamics of macromolecules traversing the NPC remains challenging to visualize on the timescale of millisecond-scale transport events. Here we used...
作者：Goetzke, Carl Christoph; Massoud, Mona; Frischbutter, Stefan; Guerra, Gabriela Maria; Ferreira-Gomes, Marta; Heinrich, Frederik; von Stuckrad, Anne Sae Lim; Wisniewski, Sebastian; Licha, Jan Robin; Bondareva, Marina; Ehlers, Lisa; Khaldi-Plassart, Samira; Javouhey, Etienne; Pons, Sylvie; Trouillet-Assant, Sophie; Ozsurekci, Yasemin; Zhang, Yu; Poli, Maria Cecilia; Discepolo, Valentina; Lo Vecchio, Andrea; Sahin, Bengue; Verboom, Murielle; Hallensleben, Michael; Heuhsen, Anja Isabelle; Astudillo, Camila; Espinosa, Yazmin; Vial Cox, Maria Cecilia; Dobbs, Kerry; Delmonte, Ottavia M.; Montealegre Sanchez, Gina A.; Magliocco, Mary; Barron, Karyl; Danielson, Jeffrey; Petrov, Lev; Unterwalder, Nadine; Sawitzki, Birgit; Matz, Mareen; Lehmann, Katrin; Gratopp, Alexander; von Bernuth, Horst; Burkhardt, Lisa-Marie; Wiese, Niklas; Peter, Lena; Schmueck-Henneresse, Michael; Amini, Leila; Maurer, Marcus; Roehmel, Jobst Fridolin; Gewurz, Benjamin E.; Yonker, Lael M.; Witkowski, Mario; Kruglov, Andrey; Mall, Marcus Alexander; Su, Helen C.; Ozen, Seza; Radbruch, Andreas; Belot, Alexandre; Durek, Pawel; Kallinich, Tilmann; Mashreghi, Mir-Farzin
作者单位：Leibniz Association; Deutsches Rheuma-Forschungszentrum (DRFZ); Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; CHU Lyon; CHU Lyon; Institut National de la Sante et de la Recherche Medicale (Inserm); CHU Lyon; CHU Lyon; Institut National de la Sante et de la Recherche Medicale (Inserm); Ecole Normale Superieure de Lyon (ENS de LYON); Centre National de la Recherche Scientifique (CNRS); Universite Claude Bernard Lyon 1; Hacettepe University; National Institutes of Health (NIH) - USA; Division of Intramural Research (DIR); Universidad del Desarrollo; University of Naples Federico II; University of Naples Federico II; Hannover Medical School; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Massachusetts Institute of Technology (MIT); Lomonosov Moscow State University; Hacettepe University; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Universite Claude Bernard Lyon 1; Ecole Normale Superieure de Lyon (ENS de LYON)
摘要：In a subset of children and adolescents, SARS-CoV-2 infection induces a severe acute hyperinflammatory shock1 termed multisystem inflammatory syndrome in children (MIS-C) at four to eight weeks after infection. MIS-C is characterized by a specific T cell expansion2 and systemic hyperinflammation3. The pathogenesis of MIS-C remains largely unknown. Here we show that acute MIS-C is characterized by impaired reactivation of virus-reactive memory T cells, which depends on increased serum levels of...
