作者：Evaborhene, Nelson Aghogho; Oga, Jessica; Udokanma, Echezona
作者单位：University of Witwatersrand; Coventry University
作者：Eisfeld, Amie J.; Biswas, Asim; Guan, Lizheng; Gu, Chunyang; Maemura, Tadashi; Trifkovic, Sanja; Wang, Tong; Babujee, Lavanya; Dahn, Randall; Halfmann, Peter J.; Barnhardt, Tera; Neumann, Gabriele; Suzuki, Yasuo; Thompson, Alexis; Swinford, Amy K.; Dimitrov, Kiril M.; Poulsen, Keith; Kawaoka, Yoshihiro
作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Shizuoka; Texas A&M University System; Texas A&M University College Station; University of Wisconsin System; University of Wisconsin Madison; University of Tokyo; University of Tokyo; Japan Institute for Health Security (JIHS); National Center for Global Health & Medicine - Japan
作者：Paul, Justine E.; Gao, Yuan; Go, Yoo Kyung; Koett, Luis E. Rodriguez; Sharma, Anisha; Chen, Manxin; Lessard, Jacob J.; Topkaya, Tolga; Leal, Cecilia; Moore, Jeffrey S.; Geubelle, Philippe H.; Sottos, Nancy R.
作者：Chen, Chun-Chi; Yu, Zhi-Pu; Liu, Ziwei; Yao, Yongpeng; Hagedoorn, Peter-Leon; Schmitz, Rob Alexander; Yang, Lujia; Yu, Lu; Liu, Aokun; Sheng, Xiang; Su, Hao; Ma, Yaqing; Wang, Te; Huang, Jian-Wen; Zhang, Lilan; Yan, Juzhang; Bao, Jinping; Cui, Chengsen; Li, Xian; Shen, Panpan; Zhang, Wuyuan; Min, Jian; Wang, Chang-Yun; Guo, Rey-Ting; Gao, Shu-Shan
作者单位：Hangzhou Normal University; Chinese Academy of Sciences; Tianjin Institute of Industrial Biotechnology, CAS; Hubei Hongshan Laboratory; Hubei University; Ocean University of China; Ocean University of China; Chinese Academy of Sciences; Institute of Microbiology, CAS; Delft University of Technology; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; Hefei Institutes of Physical Science, CAS
摘要：More than ten ergot alkaloids comprising both natural and semi-synthetic products are used to treat various diseases1,2. The central C ring forms the core pharmacophore for ergot alkaloids, giving them structural similarity to neurotransmitters, thus enabling their modulation of neurotransmitter receptors3. The haem catalase chanoclavine synthase (EasC) catalyses the construction of this ring through complex radical oxidative cyclization4. Unlike canonical catalases, which catalyse H2O2 dispro...
