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作者：Huguet, Rosa; Rodriguez-Alvarez, Xose Pedro; Martinon-Torres, Maria; Vallverdu, Josep; Lopez-Garcia, Juan Manuel; Lozano, Marina; Terradillos-Bernal, Marcos; Exposito, Isabel; Olle, Andreu; Santos, Elena; Saladie, Palmira; de Lombera-Hermida, Arturo; Moreno-Ribas, Elena; Martin-Frances, Laura; Allue, Ethel; Nunez-Lahuerta, Carmen; van der Made, Jan; Galan, Julia; Blain, Hugues-Alexandre; Caceres, Isabel; Rodriguez-Hidalgo, Antonio; Bargallo, Amelia; Mosquera, Marina; Pares, Josep Maria; Marin, Juan; Pineda, Antonio; Lordkipanidze, David; Margveslashvili, Ann; Arsuaga, Juan Luis; Carbonell, Eudald; de Castro, Jose Maria Bermudez
作者单位：Universitat Rovira i Virgili; Catalan Institute of Human Paleo-Ecology & Social Evolution (IPHES); Universitat Rovira i Virgili; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Museo Nacional de Ciencias Naturales (MNCN); Centro Nacional de Investigacion de La Evolucion Humana (CENIEH); University of London; Goldsmiths University London; University College London; Universidad Isabel I; Complutense University of Madrid; UCM-ISCIII Center for Human Evolution & Behavior; University of Oviedo; Monash University; University of Zaragoza; University of Basque Country; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Museo Nacional de Ciencias Naturales (MNCN); Leibniz Association; Senckenberg Gesellschaft fur Naturforschung (SGN); Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-Junta de Extremadura - Instituto de Arqueologia Merida (IAM); Universidad Nacional de Educacion a Distancia (UNED); Museum National d'Histoire Naturelle (MNHN); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Complutense University of Madrid
摘要：Who the first inhabitants of Western Europe were, what their physical characteristics were, and when and where they lived are some of the pending questions in the study of the settlement of Eurasia during the Early Pleistocene epoch. The available palaeoanthropological information from Western Europe is limited and confined to the Iberian Peninsula1,2. Here we present most of the midface of a hominin found at the TE7 level of the Sima del Elefante site (Sierra de Atapuerca, Spain), dated to be...
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作者：Rochmyaningsih, Dyna
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作者：Van Noorden, Richard
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作者：Witze, Alexandra
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作者：Cui, Haotian; Tejada-Lapuerta, Alejandro; Brbic, Maria; Saez-Rodriguez, Julio; Cristea, Simona; Goodarzi, Hani; Lotfollahi, Mohammad; Theis, Fabian J.; Wang, Bo
作者单位：University of Toronto; Vector Institute for Artificial Intelligence; University of Toronto; University Health Network Toronto; Peter Munk Cardiac Centre; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Technical University of Munich; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss School of Public Health (SSPH+); Swiss Institute of Bioinformatics; Ruprecht Karls University Heidelberg; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard T.H. Chan School of Public Health; University of California System; University of California San Francisco; Wellcome Trust Sanger Institute; University of Cambridge; Technical University of Munich; University of Toronto
摘要：The rapid advent of high-throughput omics technologies has created an exponential growth in biological data, often outpacing our ability to derive molecular insights. Large-language models have shown a way out of this data deluge in natural language processing by integrating massive datasets into a joint model with manifold downstream use cases. Here we envision developing multimodal foundation models, pretrained on diverse omics datasets, including genomics, transcriptomics, epigenomics, prot...
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作者：Fiorini, Elena; Malinova, Antonia; Schreyer, Daniel; Pasini, Davide; Bevere, Michele; Alessio, Giorgia; Rosa, Diego; D'Agosto, Sabrina; Azzolin, Luca; Milite, Salvatore; Andreani, Silvia; Lupo, Francesca; Veghini, Lisa; Grimaldi, Sonia; Pedron, Serena; Castellucci, Monica; Nourse, Craig; Salvia, Roberto; Malleo, Giuseppe; Ruzzenente, Andrea; Guglielmi, Alfredo; Milella, Michele; Lawlor, Rita T.; Luchini, Claudio; Agostini, Antonio; Carbone, Carmine; Pilarsky, Christian; Sottoriva, Andrea; Scarpa, Aldo; Tuveson, David A.; Bailey, Peter; Corbo, Vincenzo
作者单位：University of Verona; University of Glasgow; University of Verona; University of Verona; Human Technopole; University of Verona; University of Verona; Beatson Institute; University of Verona; University of Verona; University of Verona; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; University of Erlangen Nuremberg; Cold Spring Harbor Laboratory; Human Technopole; University of Wurzburg
摘要：Intratumour heterogeneity and phenotypic plasticity drive tumour progression and therapy resistance1,2. Oncogene dosage variation contributes to cell-state transitions and phenotypic heterogeneity3, thereby providing a substrate for somatic evolution. Nonetheless, the genetic mechanisms underlying phenotypic heterogeneity are still poorly understood. Here we show that extrachromosomal DNA (ecDNA) is a major source of high-level focal amplification in key oncogenes and a major contributor of MY...
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作者：Sugimoto, Atsushi; Saito, Yoshinobu; Wang, Guanxiong; Sun, Qiuyan; Yin, Chuan; Lee, Ki Hong; Geng, Yana; Rajbhandari, Presha; Hernandez, Celine; Steffani, Marcella; Qie, Jingran; Savage, Thomas; Goyal, Dhruv M.; Ray, Kevin C.; Neelakantan, Taruna V.; Yin, Deqi; Melms, Johannes; Lehrich, Brandon M.; Yasaka, Tyler M.; Liu, Silvia; Oertel, Michael; Lan, Tian; Guillot, Adrien; Peiseler, Moritz; Filliol, Aveline; Kanzaki, Hiroaki; Fujiwara, Naoto; Ravi, Samhita; Izar, Benjamin; Brosch, Mario; Hampe, Jochen; Remotti, Helen; Argemi, Josepmaria; Sun, Zhaoli; Kendall, Timothy J.; Hoshida, Yujin; Tacke, Frank; Fallowfield, Jonathan A.; Blockley-Powell, Storm K.; Haeusler, Rebecca A.; Steinman, Jonathan B.; Pajvani, Utpal B.; Monga, Satdarshan P.; Bataller, Ramon; Masoodi, Mojgan; Arpaia, Nicholas; Lee, Youngmin A.; Stockwell, Brent R.; Augustin, Hellmut G.; Schwabe, Robert F.
作者单位：Columbia University; Columbia University; University of Osaka; Helmholtz Association; German Cancer Research Center (DKFZ); Ruprecht Karls University Heidelberg; Columbia University; Columbia University; Columbia University; Vanderbilt University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; University of Texas System; University of Texas Southwestern Medical Center; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Columbia University; Technische Universitat Dresden; Carl Gustav Carus University Hospital; Technische Universitat Dresden; NewYork-Presbyterian Hospital; Columbia University; University of Navarra; University of Navarra; Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD; Johns Hopkins University; University of Edinburgh; Columbia University; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; University of Bern; University Hospital of Bern; Columbia University
摘要：Hepatic stellate cells (HSCs) have a central pathogenetic role in the development of liver fibrosis. However, their fibrosis-independent and homeostatic functions remain poorly understood1, 2, 3, 4-5. Here we demonstrate that genetic depletion of HSCs changes WNT activity and zonation of hepatocytes, leading to marked alterations in liver regeneration, cytochrome P450 metabolism and injury. We identify R-spondin 3 (RSPO3), an HSC-enriched modulator of WNT signalling, as responsible for these h...
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作者：Touhara, Kouki K.; Rossen, Nathan D.; Deng, Fei; Castro, Joel; Harrington, Andrea M.; Chu, Tifany; Garcia-Caraballo, Sonia; Brizuela, Mariana; O'Donnell, Tracey; Xu, Jinhao; Cil, Onur; Brierley, Stuart M.; Li, Yulong; Julius, David
作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; Peking University; South Australian Health & Medical Research Institute (SAHMRI); University of Adelaide; University of California System; University of California San Francisco
摘要：The crypt-villus structure of the small intestine serves as an essential protective barrier. The integrity of this barrier is monitored by the complex sensory system of the gut, in which serotonergic enterochromaffin (EC) cells play an important part1,2. These rare sensory epithelial cells surveil the mucosal environment for luminal stimuli and transmit signals both within and outside the gut3, 4, 5-6. However, whether EC cells in crypts and villi detect different stimuli or produce distinct p...
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作者：Forrester, Nikki
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作者：Makin, Simon
