作者：Eyting, Markus; Xie, Min; Michalik, Felix; Hess, Simon; Chung, Seunghun; Geldsetzer, Pascal
作者单位：Stanford University; Johannes Gutenberg University of Mainz; Ruprecht Karls University Heidelberg; Vienna University of Economics & Business; Stanford University; Stanford University; Chan Zuckerberg Initiative (CZI)
摘要：Neurotropic herpesviruses may be implicated in the development of dementia(1, 2, 3, 4-5). Moreover, vaccines may have important off-target immunological effects(6, 7, 8-9). Here we aim to determine the effect of live-attenuated herpes zoster vaccination on the occurrence of dementia diagnoses. To provide causal as opposed to correlational evidence, we take advantage of the fact that, in Wales, eligibility for the zoster vaccine was determined on the basis of an individual's exact date of birth...
作者：Scharfbillig, Mario; Almeida, Mara; Krieger, Kristian; Melchor, Lorenzo
作者单位：European Commission Joint Research Centre
作者：Shen, Yinan; Bai, Xueli; Zhang, Qi; Liang, Xingmei; Jin, Xinyan; Zhao, Zeda; Song, Wei; Tan, Qian; Zhao, Ronghua; Jia, William; Gu, Shanzhi; Shi, Guoming; Zheng, Ziwei; Wei, Guyue; Wang, Youlei; Fang, Tian; Li, Yuwei; Wang, Zijun; Yang, Zifan; Guo, Sida; Lin, Danni; Wei, Fang; Wang, Lei; Sun, Xiaoli; Qin, Aijun; Xie, Longshen; Qiu, Yeting; Bao, Wenqing; Rahimian, Shah; Singh, Manu; Murad, Yanal; Shang, Jianying; Chu, Min; Huang, Maoliang; Ding, Jun; Chen, Wei; Ye, Yufu; Chen, Yiwen; Li, Xiang; Liang, Tingbo
作者单位：Zhejiang University; Zhejiang University; Zhejiang University; Fudan University; Zhejiang University; Zhejiang University
摘要：Hepatocellular carcinoma remains a life-threatening malignancy with limited therapeutic options following the failure of second-line treatments1,2. Oncolytic viruses selectively replicate in and lyse cancer cells, releasing neoantigens and stimulating systemic antitumour immunity3, offering a potential therapeutic option. Here we present the results of a multicentre phase 1 clinical trial evaluating VG161, an engineered oncolytic herpes simplex virus that expresses IL-12, IL-15, IL-15R alpha a...
