8062期

最新文章

• Sensing ceramides by CYSLTR2 and P2RY6 to aggravate atherosclerosis AI翻译
  作者：Zhang, Siting; Lin, Hui; Wang, Jiale; Rui, Jingyu; Wang, Tengwei; Cai, Zeyu; Huang, Shenming; Gao, Yanxiang; Ma, Tianfeng; Fan, Rui; Dai, Rongbo; Li, Zhiqing; Jia, Yiting; Chen, Qiang; He, HaoMing; Tan, Jiaai; Zhu, Shirong; Gu, Rui; Dong, Zhigang; Li, Meihong; Xie, Enmin; Fu, Yi; Zheng, Jingang; Jiang, Changtao; Sun, Jinpeng; Kong, Wei
  作者单位：Peking University; Peking University; Shandong University; Shandong University; Peking University; Binzhou Medical University; Jinan University; Peking University; Chinese People's Liberation Army General Hospital; Peking University; Peking University; Shandong University
  摘要：Recent evidence has shown that increased levels of circulating long-chain ceramides predict atherosclerotic cardiovascular disease independently of cholesterol1,2. Although targeting ceramide signalling may provide therapeutic benefits beyond the treatment of hypercholesterolaemia, the underlying mechanism by which circulating ceramides aggravate atherosclerotic cardiovascular disease remains elusive. Here we examine whether circulating long-chain ceramides activate membrane G-protein-coupled ...
• Snapshots of acyl carrier protein shuttling in human fatty acid synthase AI翻译
  作者：Schultz, Kollin; Costa-Pinheiro, Pedro; Gardner, Lauren; Pinheiro, Laura V.; Ramirez-Solis, Julio; Gardner, Sarah M.; Wellen, Kathryn E.; Marmorstein, Ronen
  作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
  摘要：The mammalian fatty acid synthase (FASN) enzyme is a dynamic multienzyme that belongs to the megasynthase family. In mammals, a single gene encodes six catalytically active domains and a flexibly tethered acyl carrier protein (ACP) domain that shuttles intermediates between active sites for fatty acid biosynthesis1. FASN is an essential enzyme in mammalian development through the role that fatty acids have in membrane formation, energy storage, cell signalling and protein modifications. Thus, ...
• Supportive? Addictive? Abusive? How AI companions affect our mental health AI翻译
  作者：Adam, David
• World view China should review its research evaluation method AI翻译
  作者：Zhao, Yuxin
  作者单位：Hebei University of Technology
• Structure of the human dopamine transporter in complex with cocaine (vol 632, pg 678, 2024) AI翻译
  作者：Nielsen, Jeppe C.; Salomon, Kristine; Kalenderoglou, Iris E.; Bargmeyer, Sarah; Pape, Tillmann; Shahsavar, Azadeh; Loland, Claus J.
• Walking in two worlds: how an Indigenous computer scientist is using AI to preserve threatened languages AI翻译
  作者：Heidt, Amanda
• Tattoo-making tools used by ancient Maya revealed AI翻译
  作者：[Anonymous]
• Stress dynamically modulates neuronal autophagy to gate depression onset AI翻译
  作者：Yang, Liang; Guo, Chen; Zheng, Zhiwei; Dong, Yiyan; Xie, Qifeng; Lv, Zijian; Li, Min; Lu, Yangyang; Guo, Xiaonan; Deng, Rongshan; Liu, Yiqin; Feng, Yirong; Mu, Ruiqi; Zhang, Xuliang; Ma, Huan; Chen, Zhong; Zhang, Zhijun; Dong, Zhaoqi; Yang, Wei; Zhang, Xiangnan; Cui, Yihui
  作者单位：Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang Chinese Medical University; Southeast University - China; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Capital Medical University
  摘要：Chronic stress remodels brain homeostasis, in which persistent change leads to depressive disorders1. As a key modulator of brain homeostasis2, it remains elusive whether and how brain autophagy is engaged in stress dynamics. Here we discover that acute stress activates, whereas chronic stress suppresses, autophagy mainly in the lateral habenula (LHb). Systemic administration of distinct antidepressant drugs similarly restores autophagy function in the LHb, suggesting LHb autophagy as a common...
• The global human impact on biodiversity AI翻译
  作者：Keck, Francois; Peller, Tianna; Alther, Roman; Barouillet, Cecilia; Blackman, Rosetta; Capo, Eric; Chonova, Teofana; Couton, Marjorie; Fehlinger, Lena; Kirschner, Dominik; Knusel, Mara; Muneret, Lucile; Oester, Rebecca; Tapolczai, Kalman; Zhang, Heng; Altermatt, Florian
  作者单位：University of Zurich; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute of Aquatic Science & Technology (EAWAG); Centre National de la Recherche Scientifique (CNRS); Universite Savoie Mont Blanc; Umea University; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute of Aquatic Science & Technology (EAWAG); Universitat de Vic - Universitat Central de Catalunya (UVic-UCC); Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research; AgroParisTech; INRAE; Universite Paris Saclay; Institut Agro; AgroSup Dijon; INRAE; Universite Bourgogne Europe; HUN-REN; HUN-REN Balaton Limnological Research Institute; HUN-REN; HUN-REN Balaton Limnological Research Institute
  摘要：Human activities drive a wide range of environmental pressures, including habitat change, pollution and climate change, resulting in unprecedented effects on biodiversity1,2. However, despite decades of research, generalizations on the dimensions and extent of human impacts on biodiversity remain ambiguous. Mixed views persist on the trajectory of biodiversity at the local scale3 and even more so on the biotic homogenization of biodiversity across space4,5. We compiled 2,133 publications cover...
• Climate risk for younger generations is set to soar AI翻译
  作者：Gualdi, Rosanna; Muttarak, Raya
  作者单位：University of Bologna