作者：Yoo, Dongahn; Rhie, Arang; Hebbar, Prajna; Antonacci, Francesca; Logsdon, Glennis A.; Solar, Steven J.; Antipov, Dmitry; Pickett, Brandon D.; Safonova, Yana; Montinaro, Francesco; Luo, Yanting; Malukiewicz, Joanna; Storer, Jessica M.; Lin, Jiadong; Sequeira, Abigail N.; Mangan, Riley J.; Hickey, Glenn; Monfort Anez, Graciela; Balachandran, Parithi; Bankevich, Anton; Beck, Christine R.; Biddanda, Arjun; Borchers, Matthew; Bouffard, Gerard G.; Brannan, Emry; Brooks, Shelise Y.; Carbone, Lucia; Carrel, Laura; Chan, Agnes P.; Crawford, Juyun; Diekhans, Mark; Engelbrecht, Eric; Feschotte, Cedric; Formenti, Giulio; Garcia, Gage H.; de Gennaro, Luciana; Gilbert, David; Green, Richard E.; Guarracino, Andrea; Gupta, Ishaan; Haddad, Diana; Han, Junmin; Harris, Robert S.; Hartley, Gabrielle A.; Harvey, William T.; Hiller, Michael; Hoekzema, Kendra; Houck, Marlys L.; Jeong, Hyeonsoo; Kamali, Kaivan; Kellis, Manolis; Kille, Bryce; Lee, Chul; Lee, Youngho; Lees, William; Lewis, Alexandra P.; Li, Qiuhui; Loftus, Mark; Loh, Yong Hwee Eddie; Loucks, Hailey; Ma, Jian; Mao, Yafei; Martinez, Juan F. I.; Masterson, Patrick; McCoy, Rajiv C.; Mcgrath, Barbara; Mckinney, Sean; Meyer, Britta S.; Miga, Karen H.; Mohanty, Saswat K.; Munson, Katherine M.; Pal, Karol; Pennell, Matt; Pevzner, Pavel A.; Porubsky, David; Potapova, Tamara; Ringeling, Francisca R.; Rocha, Joana L.; Ryder, Oliver A.; Sacco, Samuel; Saha, Swati; Sasaki, Takayo; Schatz, Michael C.; Schork, Nicholas J.; Shanks, Cole; Smeds, Linnea; Son, Dongmin R.; Steiner, Cynthia; Sweeten, Alexander P.; Tassia, Michael G.; Thibaud-Nissen, Francoise; Torres-Gonzalez, Edmundo; Trivedi, Mihir; Wei, Wenjie; Wertz, Julie; Yang, Muyu; Zhang, Panpan; Zhang, Shilong; Zhang, Yang; Zhang, Zhenmiao; Zhao, Sarah A.; Zhu, Yixin; Jarvis, Erich D.; Gerton, Jennifer L.; Rivas-Gonzalez, Iker; Paten, Benedict; Szpiech, Zachary A.; Huber, Christian D.; Lenz, Tobias L.; Konkel, Miriam K.; Yi, Soojin V.; Canzar, Stefan; Watson, Corey T.; Sudmant, Peter H.; Molloy, Erin; Garrison, Erik; Lowe, Craig B.; Ventura, Mario; O'Neill, Rachel J.; Koren, Sergey; Makova, Kateryna D.; Phillippy, Adam M.; Eichler, Evan E.
作者单位：University of Washington; University of Washington Seattle; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI); University of California System; University of California Santa Cruz; Universita degli Studi di Bari Aldo Moro; University of Pennsylvania; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of Tartu; Duke University; University of Hamburg; Leibniz Association; Deutsches Primatenzentrum (DPZ); University of Connecticut; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Massachusetts Institute of Technology (MIT); Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard Medical School; Stowers Institute for Medical Research; Jackson Laboratory; University of Connecticut; Johns Hopkins University; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI); University of Connecticut; Oregon Health & Science University; Oregon Health & Science University; Oregon National Primate Research Center; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health; Translational Genomics Research Institute; City of Hope; University of Louisville; Cornell University; Rockefeller University; University of California System; University of California Santa Cruz; University of Tennessee System; University of Tennessee Health Science Center; University of California System; University of California San Diego; National Institutes of Health (NIH) - USA; NIH National Library of Medicine (NLM); Shanghai Jiao Tong University; Leibniz Association; Senckenberg Gesellschaft fur Naturforschung (SGN); Goethe University Frankfurt; Rice University; Rockefeller University; Seoul National University (SNU); Bar Ilan University; Johns Hopkins University; Clemson University; Clemson University; University of California System; University of California Santa Barbara; Carnegie Mellon University; Zhejiang University; Shanghai Jiao Tong University; Cornell University; University of Regensburg; University of California System; University of California Berkeley; University of California System; University of California Santa Barbara; Westlake University; Huazhong Agricultural University; Howard Hughes Medical Institute; Max Planck Society; University of California System; University of California Santa Barbara; University of California System; University of California Berkeley; University System of Maryland; University of Maryland College Park
摘要：The most dynamic and repetitive regions of great ape genomes have traditionally been excluded from comparative studies(1-3). Consequently, our understanding of the evolution of our species is incomplete. Here we present haplotype-resolved reference genomes and comparative analyses of six ape species: chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan and siamang. We achieve chromosome-level contiguity with substantial sequence accuracy (<1 error in 2.7 megabases) and completely...
作者：Kiyono, Hiroshi; Ernst, Peter B.
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; Chiba University; Chiba University; University of California System; University of California Davis
摘要：Beginning with Edward Jenner's discovery of the smallpox vaccine, the ever-expanding repertoire of vaccines against pathogens has saved many lives. During the COVID-19 pandemic, a revolutionary mRNA injectable vaccine emerged that effectively controlled the severity of disease caused by SARS-CoV-2. This vaccine induced potent antigen-specific neutralizing serum IgG antibodies, but was limited in its ability to prevent viral invasion at the respiratory surfaces. Nasal vaccines have attracted at...
作者：Pae, Juhee; Schwan, Niklas; Ottino-Loffler, Bertrand; Dewitt, William S.; Garg, Amar; Bortolatto, Juliana; Vora, Ashni A.; Shen, Jin-Jie; Hobbs, Alvaro; Castro, Tiago B. R.; Mesin, Luka; Matsen, Frederick A.; Meyer-Hermann, Michael; Victora, Gabriel D.
作者单位：Rockefeller University; Helmholtz Association; Helmholtz-Center for Infection Research; Rockefeller University; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; Fred Hutchinson Cancer Center; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle
摘要：In the course of antibody affinity maturation, germinal centre (GC) B cells mutate their immunoglobulin heavy- and light-chain genes in a process known as somatic hypermutation (SHM)1, 2, 3-4. Panels of mutant B cells with different binding affinities for antigens are then selected in a Darwinian manner, which leads to a progressive increase in affinity among the population5. As with any Darwinian process, rare gain-of-fitness mutations must be identified and common loss-of-fitness mutations a...
作者：Song, Yong-Hui; Li, Bo; Wang, Zi-Jian; Tai, Xiao-Lin; Ding, Guan-Jie; Li, Zi-Du; Xu, Huaiyu; Hao, Jing-Ming; Song, Kuang-Hui; Feng, Li-Zhe; Hu, Ya-Lan; Yin, Yi-Chen; Zhu, Bai-Sheng; Zhang, Guozhen; Ju, Huanxin; Zheng, Guanhaojie; Hu, Wei; Lin, Yue; Fan, Fengjia; Yao, Hong-Bin
作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Hefei National Laboratory; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; Shanghai Advanced Research Institute, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
摘要：Metal-halide perovskites are promising light-emitter candidates for next-generation light-emitting diodes (LEDs)1, 2, 3, 4, 5, 6, 7-8. Achieving high brightness and efficiency simultaneously in pure-red perovskite LEDs (PeLEDs) is an ongoing goal9,10. Three-dimensional (3D) CsPbI3-xBrx emitters have excellent carrier transport capability and high colour purity, which could allow efficient and ultrabright pure-red PeLEDs. However, such devices are prone to efficiency roll-off, resulting in low ...
