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作者：Sayer, Catherine A.; Fernando, Eresha; Jimenez, Randall R.; Macfarlane, Nicholas B. W.; Rapacciuolo, Giovanni; Boehm, Monika; Brooks, Thomas M.; Contreras-MacBeath, Topiltzin; Cox, Neil A.; Harrison, Ian; Hoffmann, Michael; Jenkins, Richard; Smith, Kevin G.; Vie, Jean-Christophe; Abbott, John C.; Allen, David J.; Allen, Gerald R.; Barrios, Violeta; Boudot, Jean-Pierre; Carrizo, Savrina F.; Charvet, Patricia; Clausnitzer, Viola; Congiu, Leonardo; Crandall, Keith A.; Cumberlidge, Neil; Cuttelod, Annabelle; Dalton, James; Daniels, Adam G.; De Grave, Sammy; De Knijf, Geert; Dijkstra, Klaas-Douwe B.; Dow, Rory A.; Freyhof, Joerg; Garcia, Nieves; Gessner, Joern; Getahun, Abebe; Gibson, Claudine; Gollock, Matthew J.; Grant, Michael I.; Groom, Alice E. R.; Hammer, Michael P.; Hammerson, Geoffrey A.; Hilton-Taylor, Craig; Hodgkinson, Laurel; Holland, Robert A.; Jabado, Rima W.; Juffe Bignoli, Diego; Kalkman, Vincent J.; Karimov, Bakhtiyor K.; Kipping, Jens; Kottelat, Maurice; Laleye, Philippe A.; Larson, Helen K.; Lintermans, Mark; Lozano, Federico; Ludwig, Arne; Lyons, Timothy J.; Maiz-Tome, Laura; Molur, Sanjay; Ng, Heok Hee; Numa, Catherine; Palmer-Newton, Amy F.; Pike, Charlotte; Pippard, Helen E.; Polaz, Carla N. M.; Pollock, Caroline M.; Raghavan, Rajeev; Rand, Peter S.; Ravelomanana, Tsilavina; Reis, Roberto E.; Rigby, Cassandra L.; Scott, Janet A.; Skelton, Paul H.; Sloat, Matthew R.; Snoeks, Jos; Stiassny, Melanie L. J.; Tan, Heok Hui; Taniguchi, Yoshinori; Thorstad, Eva B.; Tognelli, Marcelo F.; Torres, Armi G.; Torres, Yan; Tweddle, Denis; Watanabe, Katsutoshi; Westrip, James R. S.; Wright, Emma G. E.; Zhang, E.; Darwall, William R. T.
作者单位：Universidad Autonoma del Estado de Morelos; Conservation International; Northern Arizona University; Zoological Society of London; University of Alabama System; University of Alabama Tuscaloosa; Western Australian Museum; Centre National de la Recherche Scientifique (CNRS); Universite de Lorraine; Universidade Federal do Ceara; University of Padua; George Washington University; Northern Michigan University; University of Oxford; Research Institute for Nature & Forest; Naturalis Biodiversity Center; University of Malaysia Sarawak; Leibniz Institut fur Evolutions und Biodiversitatsforschung; Leibniz Association; Leibniz Institut fur Gewasserokologie und Binnenfischerei (IGB); Addis Ababa University; James Cook University; James Cook University; Universitas Hasanuddin; Royal Society for Protection of Birds; University of Southampton; University of Kent; Tashkent Institute of Irrigation & Agricultural Mechanization Engineers; University of Abomey Calavi; University of Canberra; Leibniz Institut fur Zoo und Wildtierforschung; Humboldt University of Berlin; National University of Singapore; Kerala University of Fisheries & Ocean Studies; University Antananarivo; Pontificia Universidade Catolica Do Rio Grande Do Sul; National Research Foundation - South Africa; South African Institute for Aquatic Biodiversity; Royal Museum for Central Africa; KU Leuven; American Museum of Natural History (AMNH); Meijo University; Norwegian Institute Nature Research; Mindanao State University System; Mindanao State University-IIT; Kyoto University; Chinese Academy of Sciences; Institute of Hydrobiology, CAS
摘要：Freshwater ecosystems are highly biodiverse(1) and important for livelihoods and economic development(2), but are under substantial stress(3). To date, comprehensive global assessments of extinction risk have not included any speciose groups primarily living in freshwaters. Consequently, data from predominantly terrestrial tetrapods(4,5) are used to guide environmental policy(6) and conservation prioritization(7), whereas recent proposals for target setting in freshwaters use abiotic factors(8...
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作者：Mackerell, Alex
作者单位：University System of Maryland; University of Maryland Baltimore
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作者：Gonzalez, Kevin C.; Negrean, Adrian; Liao, Zhenrui; Terada, Satoshi; Zhang, Guofeng; Lee, Sungmoo; Ocsai, Katalin; Rozsa, Balazs J.; Lin, Michael Z.; Polleux, Franck; Losonczy, Attila
作者单位：Columbia University; Columbia University; Stanford University; Budapest University of Technology & Economics; HUN-REN; HUN-REN Institute of Experimental Medicine; Pazmany Peter Catholic University; Stanford University; Allen Institute for Brain Science; Sun Yat Sen University
摘要：A central question in neuroscience is how synaptic plasticity shapes the feature selectivity of neurons in behaving animals1. Hippocampal CA1 pyramidal neurons display one of the most striking forms of feature selectivity by forming spatially and contextually selective receptive fields called place fields, which serve as a model for studying the synaptic basis of learning and memory. Various forms of synaptic plasticity have been proposed as cellular substrates for the emergence of place field...
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作者：Lyu, Aram; Fan, Zenghua; Clark, Matthew; Lea, Averey; Luong, Diamond; Setayesh, Ali; Starzinski, Alec; Wolters, Rachel; Arias-Badia, Marcel; Allaire, Kate; Wu, Kai; Gurunathan, Vibha; Valderrabano, Laura; Wei, Xiao X.; Miller, Richard A.; Van Allen, Eliezer M.; Fong, Lawrence
作者单位：University of California System; University of California San Francisco; Fred Hutchinson Cancer Center; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of California System; University of California San Francisco; UCSF Medical Center; UCSF Helen Diller Family Comprehensive Cancer Center
摘要：Patients with advanced metastatic castration-resistant prostate cancer (mCRPC) are refractory to immune checkpoint inhibitors (ICIs)1,2, partly because there are immunosuppressive myeloid cells in tumours3,4. However, the heterogeneity of myeloid cells has made them difficult to target, making blockade of the colony stimulating factor-1 receptor (CSF1R) clinically ineffective. Here we use single-cell profiling on patient biopsies across the disease continuum and find that a distinct population...
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作者：Harris, Stephen J.; Schwietzke, Stefan; France, James L.; Velandia Salinas, Nataly; Meixus Fernandez, Tania; Randles, Cynthia; Guanter, Luis; Irakulis-Loitxate, Itziar; Calcan, Andreea; Aben, Ilse; Abrahamsson, Katarina; Balcombe, Paul; Berchet, Antoine; Biddle, Louise C.; Bittig, Henry C.; Boettcher, Christian; Bouvard, Timo; Brostroem, Goeran; Bruch, Valentin; Cassiani, Massimo; Chipperfield, Martyn P.; Ciais, Philippe; Damm, Ellen; Dammers, Enrico; Denier van der Gon, Hugo; Dogniaux, Matthieu; Dowd, Emily; Dupouy, Francois; Eckhardt, Sabine; Evangeliou, Nikolaos; Feng, Wuhu; Jia, Mengwei; Jiang, Fei; Kaiser-Weiss, Andrea K.; Kamoun, Ines; Kerridge, Brian J.; Lampert, Astrid; Lana, Jose; Li, Fei; Maasakkers, Joannes D.; Maclean, Jean-Philippe W.; Mamtimin, Buhalqem; Marshall, Julia; Mauger, Gedeon; Mekkas, Anouar; Mielke, Christian; Mohrmann, Martin; Moore, David P.; Nanni, Riccardo; Paetzold, Falk; Pison, Isabelle; Pisso, Ignacio; Platt, Stephen M.; Prea, Raphael; Queste, Bastien Y.; Ramonet, Michel; Rehder, Gregor; Remedios, John J.; Reum, Friedemann; Roiger, Anke; Schmidbauer, Norbert; Siddans, Richard; Sunkisala, Anusha; Thompson, Rona L.; Varon, Daniel J.; Ventress, Lucy J.; Wilson, Chris; Zhang, Yuzhong
作者单位：University of London; Royal Holloway University London; Universitat Politecnica de Valencia; Vrije Universiteit Amsterdam; University of Gothenburg; University of London; Queen Mary University London; Universite Paris Saclay; CEA; Leibniz Institut fur Ostseeforschung Warnemunde; Universite Paris Saclay; CEA; NILU; University of Leeds; University of Leeds; Helmholtz Association; Alfred Wegener Institute, Helmholtz Centre for Polar & Marine Research; Netherlands Organization Applied Science Research; University of Leeds; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC National Centre for Atmospheric Science; Nanjing University; UK Research & Innovation (UKRI); Science & Technology Facilities Council (STFC); STFC Rutherford Appleton Laboratory; UK Research & Innovation (UKRI); Science & Technology Facilities Council (STFC); STFC Rutherford Appleton Laboratory; Braunschweig University of Technology; Helmholtz Association; German Aerospace Centre (DLR); University of Leicester; University of Leicester; Harvard University; Westlake University
摘要：The amount of methane released to the atmosphere from the Nord Stream subsea pipeline leaks remains uncertain, as reflected in a wide range of estimates1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17-18. A lack of information regarding the temporal variation in atmospheric emissions has made it challenging to reconcile pipeline volumetric (bottom-up) estimates1, 2, 3, 4, 5, 6, 7-8 with measurement-based (top-down) estimates8, 9, 10, 11, 12, 13, 14, 15, 16, 17-18. Here we simulate pip...
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作者：Degenhardt, Maximilia F. S.; Degenhardt, Hermann F.; Bhandari, Yuba R.; Lee, Yun-Tzai; Ding, Jienyu; Yu, Ping; Heinz, William F.; Stagno, Jason R.; Schwieters, Charles D.; Watts, Norman R.; Wingfield, Paul T.; Rein, Alan; Zhang, Jinwei; Wang, Yun-Xing
作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK); National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
摘要：Much of the human genome is transcribed into RNAs1, many of which contain structural elements that are important for their function. Such RNA molecules-including those that are structured and well-folded2-are conformationally heterogeneous and flexible, which is a prerequisite for function3,4, but this limits the applicability of methods such as NMR, crystallography and cryo-electron microscopy for structure elucidation. Moreover, owing to the lack of a large RNA structure database, and no cle...
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作者：Witze, Alexandra
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作者：Abalkina, Anna; Aquarius, Rene; Bik, Elisabeth; Bimler, David; Bishop, Dorothy; Byrne, Jennifer; Cabanac, Guillaume; Day, Adam; Labbe, Cyril; Wise, Nick
作者单位：Free University of Berlin; Radboud University Nijmegen; University of Oxford; University of Sydney; Universite de Toulouse; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Taylor & Francis; University of Cambridge
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作者：Rood, Jennifer E.; Wynne, Samantha; Robson, Lucia; Hupalowska, Anna; Randell, John; Teichmann, Sarah A.; Regev, Aviv
作者单位：Roche Holding; Genentech; Roche Holding USA; University of Cambridge
摘要：With the convergence of notable advances in molecular and spatial profiling methods and new computational approaches taking advantage of artificial intelligence and machine learning, the construction of cell atlases is progressing from data collection to atlas integration and beyond. Here, we explore five ways in which cell atlases, including the Human Cell Atlas, are already revealing valuable biological insights, and how they are poised to provide even greater benefits in the coming years. I...
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作者：Callaway, Ewen
