2025

最新文章

• Native DGC structure rationalizes muscular dystrophy-causing mutations AI翻译
  作者：Liu, Shiheng; Su, Tiantian; Xia, Xian; Zhou, Z. Hong
  作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
  摘要：Duchenne muscular dystrophy (DMD) is a severe X-linked recessive disorder marked by progressive muscle wasting leading to premature mortality1,2. Discovery of the DMD gene encoding dystrophin both revealed the cause of DMD and helped identify a family of at least ten dystrophin-associated proteins at the muscle cell membrane, collectively forming the dystrophin-glycoprotein complex (DGC)3, 4, 5, 6, 7, 8-9. The DGC links the extracellular matrix to the cytoskeleton, but, despite its importance,...
• Why farmers are beginning to take their government to court over climate change AI翻译
  作者：Blattner, Charlotte E.; Finger, Robert; Ingold, Karin
  作者单位：University of Lausanne; University of Bern; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Bern
  摘要：How a Swiss lawsuit is recasting agriculture's role in climate policy.
• Continental influx and pervasive matrilocality in Iron Age Britain AI翻译
  作者：Cassidy, Lara M.; Russell, Miles; Smith, Martin; Delbarre, Gabrielle; Cheetham, Paul; Manley, Harry; Mattiangeli, Valeria; Breslin, Emily M.; Jackson, Iseult; Mccann, Maeve; Little, Harry; O'Connor, Ciaran G.; Heaslip, Beth; Lawson, Daniel; Endicott, Phillip; Bradley, Daniel G.
  作者单位：Trinity College Dublin; Bournemouth University; Bournemouth University; University of Bristol; University of Tartu; University of Hawaii System; University of Hawaii Manoa; Eberhard Karls University of Tubingen; Museum National d'Histoire Naturelle (MNHN)
  摘要：Roman writers found the relative empowerment of Celtic women remarkable1. In southern Britain, the Late Iron Age Durotriges tribe often buried women with substantial grave goods2. Here we analyse 57 ancient genomes from Durotrigian burial sites and find an extended kin group centred around a single maternal lineage, with unrelated (presumably inward migrating) burials being predominantly male. Such a matrilocal pattern is undescribed in European prehistory, but when we compare mitochondrial ha...
• Four tips for writing the perfect 'cold e-mail' in job applications AI翻译
  作者：Nordling, Linda
  摘要：These strategies can transform your unsolicited applications from forgettable to fabulous.
• Humanity needs to diversify its lithium sources AI翻译
  作者：[Anonymous]
• Structure and assembly of the dystrophin glycoprotein complex AI翻译
  作者：Wan, Li; Ge, Xiaofei; Xu, Qikui; Huang, Gaoxingyu; Yang, Tiandi; Campbell, Kevin P.; Yan, Zhen; Wu, Jianping
  作者单位：Westlake University; Westlake Laboratory; Westlake University; Tsinghua University; University of Iowa; Howard Hughes Medical Institute; University of Iowa; University of Iowa; University of Iowa; Harvard University; Harvard Medical School
  摘要：The dystrophin glycoprotein complex (DGC) has a crucial role in maintaining cell membrane stability and integrity by connecting the intracellular cytoskeleton with the surrounding extracellular matrix1, 2-3. Dysfunction of dystrophin and its associated proteins results in muscular dystrophy, a disorder characterized by progressive muscle weakness and degeneration4,5. Despite the important roles of the DGC in physiology and pathology, its structural details remain largely unknown, hindering a c...
• Industrial projects in Chile threaten clear views of the Universe AI翻译
  作者：Lavandero, Sergio
• Women were at the centre of social networks in Iron Age Britain AI翻译
  作者：Gnecchi-Ruscone, Guido Alberto
  作者单位：Max Planck Society; Masaryk University
  摘要：Evidence from 2,000-year-old DNA reveals that women in Celtic society stayed in their ancestral communities after marriage, whereas men were mobile, and that the southern coast of Britain was a hotspot for cultural exchange.
• Quantum stock whiplash: what's next for quantum computing? AI翻译
  作者：Castelvecchi, Davide
• Ultrabroadband integrated electro-optic frequency comb in lithium tantalate AI翻译
  作者：Zhang, Junyin; Wang, Chengli; Denney, Connor; Riemensberger, Johann; Lihachev, Grigory; Hu, Jianqi; Kao, Wil; Blesin, Terence; Kuznetsov, Nikolai; Li, Zihan; Churaev, Mikhail; Ou, Xin; Santamaria-Botello, Gabriel; Kippenberg, Tobias J.
  作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Colorado School of Mines; Chinese Academy of Sciences; Shanghai Institute of Microsystem & Information Technology, CAS; Norwegian University of Science & Technology (NTNU)
  摘要：The integrated frequency comb generator based on Kerr parametric oscillation1 has led to chip-scale, gigahertz-spaced combs with new applications spanning hyperscale telecommunications, low-noise microwave synthesis, light detection and ranging, and astrophysical spectrometer calibration2, 3, 4, 5-6. Recent progress in lithium niobate (LiNbO3) photonic integrated circuits (PICs) has resulted in chip-scale, electro-optic (EO) frequency combs7,8, offering precise comb-line positioning and simple...