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作者：Won, Tae Hyung; Arifuzzaman, Mohammad; Parkhurst, Christopher N.; Miranda, Isabella C.; Zhang, Bingsen; Hu, Elin; Kashyap, Sanchita; Letourneau, Jeffrey; Jin, Wen-Bing; Fu, Yousi; Guzior, Douglas V.; Quinn, Robert A.; Guo, Chun-Jun; David, Lawrence A.; Artis, David; Schroeder, Frank C.
作者单位：Cornell University; Boyce Thompson Institute for Plant Research; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Duke University; Michigan State University; Michigan State University; Cornell University; Weill Cornell Medicine; Duke University; Cornell University; Weill Cornell Medicine; Pochon Cha University
摘要：Metabolites derived from the intestinal microbiota, including bile acids (BA), extensively modulate vertebrate physiology, including development(1), metabolism(2, 3-4), immune responses(5, 6-7) and cognitive function(8). However, to what extent host responses balance the physiological effects of microbiota-derived metabolites remains unclear(9,10). Here, using untargeted metabolomics of mouse tissues, we identified a family of BA-methylcysteamine (BA-MCY) conjugates that are abundant in the in...
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作者：Burdanov, Artem Y.; de Wit, Julien; Broz, Miroslav; Mueller, Thomas G.; Hoffmann, Tobias; Ferrais, Marin; Micheli, Marco; Jehin, Emmanuel; Parrott, Daniel; Hasler, Samantha N.; Binzel, Richard P.; Ducrot, Elsa; Kreidberg, Laura; Gillon, Michael; Greene, Thomas P.; Grundy, Will M.; Kareta, Theodore; Lagage, Pierre-Olivier; Moskovitz, Nicholas; Thirouin, Audrey; Thomas, Cristina A.; Zieba, Sebastian
作者单位：Massachusetts Institute of Technology (MIT); Charles University Prague; Max Planck Society; Carl von Ossietzky Universitat Oldenburg; State University System of Florida; University of Central Florida; University of Liege; Universite Paris Saclay; CEA; Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; Max Planck Society; University of Liege; National Aeronautics & Space Administration (NASA); NASA Ames Research Center; Northern Arizona University; Leiden University - Excl LUMC; Leiden University
摘要：Asteroid discoveries are essential for planetary-defence efforts aiming to prevent impacts with Earth(1), including the more frequent(2) megaton explosions from decametre impactors(3, 4, 5-6). Although large asteroids (>= 100kilometres) have remained in the main belt since their formation(7), small asteroids are commonly transported to the near-Earth object (NEO) population(8,9). However, owing to the lack of direct observational constraints, their size-frequency distribution (SFD)-which infor...
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作者：Lee, Taekhyeon; Park, Min Tae; Ko, Hye-Won; Oh, Jung Hyun; Ko, San; Hwang, Seongmun; Jang, Jae Gwang; Baek, Geon-Woo; Kim, Se Kwon; Lee, Hyun-Woo; Jung, Myung-Hwa; Kim, Kab-Jin; Lee, Kyung-Jin
作者单位：Korea Advanced Institute of Science & Technology (KAIST); Sogang University; Korea Advanced Institute of Science & Technology (KAIST); Pohang University of Science & Technology (POSTECH); Asia Pacific Center for Theoretical Physics
摘要：A particle current generated by pumping in the absence of gradients in potential energy, density or temperature(1) is associated with non-trivial dynamics. A representative example is charge pumping that is associated with the quantum Hall effect(2) and the quantum anomalous Hall effect(3). Spin pumping, the spin equivalent of charge pumping, refers to the emission of a spin current by magnetization dynamics(4, 5, 6-7). Previous studies have focused solely on transversal spin pumping arising f...
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作者：Doglioni, Ginevra; Fernandez-Garcia, Juan; Igelmann, Sebastian; Altea-Manzano, Patricia; Blomme, Arnaud; La Rovere, Rita; Liu, Xiao-Zheng; Liu, Yawen; Tricot, Tine; Nobis, Max; An, Ning; Leclercq, Marine; El Kharraz, Sarah; Karras, Panagiotis; Hsieh, Yu-Heng; Solari, Fiorella A.; Martins Nascentes Melo, Luiza; Allies, Gabrielle; Scopelliti, Annalisa; Rossi, Matteo; Vermeire, Ines; Broekaert, Dorien; Ferreira Campos, Ana Margarida; Neven, Patrick; Maetens, Marion; Van Baelen, Karen; Alkan, H. Furkan; Planque, Melanie; Floris, Giuseppe; Sickmann, Albert; Tasdogan, Alpaslan; Marine, Jean-Christophe; Scheele, Colinda L. G. J.; Desmedt, Christine; Bultynck, Geert; Close, Pierre; Fendt, Sarah-Maria
作者单位：Flanders Institute for Biotechnology (VIB); KU Leuven; University of Liege; KU Leuven; Jiangsu University; Flanders Institute for Biotechnology (VIB); KU Leuven; Flanders Institute for Biotechnology (VIB); Flanders Institute for Biotechnology (VIB); KU Leuven; Dortmund University of Technology; Leibniz Association; Leibniz Institut fur Analytische Wissenschaften (ISAS); University of Duisburg Essen; Helmholtz Association; German Cancer Research Center (DKFZ); KU Leuven; University Hospital Leuven; KU Leuven; Flanders Institute for Biotechnology (VIB); KU Leuven; University Hospital Leuven; KU Leuven; Ruhr University Bochum; Consejo Superior de Investigaciones Cientificas (CSIC); University of Sevilla; Universidad Pablo de Olavide; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center
摘要：Lung metastases occur in up to 54% of patients with metastatic tumours(1,2). Contributing factors to this high frequency include the physical properties of the pulmonary system and a less oxidative environment that may favour the survival of cancer cells(3). Moreover, secreted factors from primary tumours alter immune cells and the extracellular matrix of the lung, creating a permissive pre-metastatic environment primed for the arriving cancer cells(4,5). Nutrients are also primed during pre-m...
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作者：Falk, Dean
作者单位：State University System of Florida; Florida State University
摘要：A fossil found in South Africa 100 years ago provides insights into the emergence of a crucial - and unusual - life stage.
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作者：O'Dwyer, Michael R.; Azagury, Meir; Furlong, Katharine; Alsheikh, Amani; Hall-Ponsele, Elisa; Pinto, Hugo; Fyodorov, Dmitry V.; Jaber, Mohammad; Papachristoforou, Eleni; Benchetrit, Hana; Ashmore, James; Makedonski, Kirill; Rahamim, Moran; Hanzevacki, Marta; Yassen, Hazar; Skoda, Samuel; Levy, Adi; Pollard, Steven M.; Skoultchi, Arthur I.; Buganim, Yosef; Soufi, Abdenour
作者单位：University of Edinburgh; University of Edinburgh; Hebrew University of Jerusalem; University of Edinburgh; King Abdulaziz City for Science & Technology; Yeshiva University
摘要：Cellular identity requires the concerted action of multiple transcription factors (TFs) bound together to enhancers of cell-type-specific genes. Despite TFs recognizing specific DNA motifs within accessible chromatin, this information is insufficient to explain how TFs select enhancers(1). Here we compared four different TF combinations that induce different cell states, analysing TF genome occupancy, chromatin accessibility, nucleosome positioning and 3D genome organization at the nucleosome ...
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作者：Furuhashi, Kazuhiro; Kakiuchi, Miwako; Ueda, Ryosuke; Oda, Hiroko; Ummarino, Simone; Ebralidze, Alexander K.; Bassal, Mahmoud A.; Meng, Chen; Sato, Tatsuyuki; Lyu, Jing; Han, Min-guk; Maruyama, Shoichi; Watanabe, Yu; Sawa, Yuriko; Kato, Daisuke; Wake, Hiroaki; Reizis, Boris; Frangos, John A.; Owens, David M.; Tenen, Daniel G.; Ghiran, Ionita C.; Robson, Simon C.; Fujisaki, Joji
作者单位：Columbia University; Columbia University; Nagoya University; Nagoya University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; National University of Singapore; Hubei University of Medicine; Nagoya University; New York University; La Jolla Bioengineering Institute; Columbia University; NewYork-Presbyterian Hospital; Columbia University; NewYork-Presbyterian Hospital; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School
摘要：Stem cells reside in specialized microenvironments, termed niches, at several different locations in tissues(1, 2-3). The differential functions of heterogeneous stem cells and niches are important given the increasing clinical applications of stem-cell transplantation and immunotherapy. Whether hierarchical structures among stem cells at distinct niches exist and further control aspects of immune tolerance is unknown. Here we describe previously unknown new hierarchical arrangements in haemat...
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作者：Wolff, Eric W.; Mulvaney, Robert; Grieman, Mackenzie M.; Hoffmann, Helene M.; Humby, Jack; Nehrbass-Ahles, Christoph; Rhodes, Rachael H.; Rowell, Isobel F.; Sime, Louise C.; Fischer, Hubertus; Stocker, Thomas F.; Landais, Amaelle; Parrenin, Frederic; Steig, Eric J.; Duetsch, Marina; Golledge, Nicholas R.
作者单位：University of Cambridge; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC British Antarctic Survey; Eberhard Karls University of Tubingen; National Physical Laboratory - UK; University of Bern; University of Bern; CEA; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); INRAE; Institut National Polytechnique de Grenoble; Institut de Recherche pour le Developpement (IRD); University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Vienna; Victoria University Wellington
摘要：The fate of the West Antarctic Ice Sheet (WAIS)(1) is the largest cause of uncertainty in long-term sea-level projections. In the last interglacial (LIG) around 125,000 years ago, data suggest that sea level was several metres higher than today(2, 3-4), and required a significant contribution from Antarctic ice loss, with WAIS usually implicated. Antarctica and the Southern Ocean were warmer than today(5, 6, 7-8), by amounts comparable to those expected by 2100 under moderate to high future wa...
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作者：Chiang, Chen-Yu; Ohashi, Masao; Le, Jessie; Chen, Pan-Pan; Zhou, Qingyang; Qu, Songrong; Bat-Erdene, Undramaa; Hematian, Shabnam; Rodriguez, Jose A.; Houk, K. N.; Guo, Yisong; Loo, Joseph A.; Tang, Yi
作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of North Carolina; University of North Carolina Greensboro; Carnegie Mellon University; University of California System; University of California Los Angeles
摘要：Carbon-hydrogen (C-H) bonds are the foundation of essentially every organic molecule, making them an ideal place to do chemical synthesis. The key challenge is achieving selectivity for one particular C(sp(3))-H bond(1, 2-3). In recent years, metalloenzymes have been found to perform C(sp(3))-H bond functionalization(4,5). Despite substantial progresses in the past two decades(6,7), enzymatic halogenation and pseudohalogenation of unactivated C(sp(3))-H-providing a functional handle for furthe...
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作者：Won, Tae Hyung; Arifuzzaman, Mohammad; Parkhurst, Christopher N.; Miranda, Isabella C.; Zhang, Bingsen; Hu, Elin; Kashyap, Sanchita; Letourneau, Jeffrey; Jin, Wen-Bing; Fu, Yousi; Guzior, Douglas V.; Quinn, Robert A.; Guo, Chun-Jun; David, Lawrence A.; Artis, David; Schroeder, Frank C.
作者单位：Cornell University; Boyce Thompson Institute for Plant Research; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Duke University; Michigan State University; Michigan State University; Cornell University; Weill Cornell Medicine; Duke University; Cornell University; Weill Cornell Medicine; Pochon Cha University
摘要：Metabolites derived from the intestinal microbiota, including bile acids (BA), extensively modulate vertebrate physiology, including development(1), metabolism(2, 3-4), immune responses(5, 6-7) and cognitive function(8). However, to what extent host responses balance the physiological effects of microbiota-derived metabolites remains unclear(9,10). Here, using untargeted metabolomics of mouse tissues, we identified a family of BA-methylcysteamine (BA-MCY) conjugates that are abundant in the in...
