Science

最新文章

• Neurobiology AI翻译
  作者：Santos, Julio
  作者单位：Universidade do Sul de Santa Catarina
• Catalysis at the crossroads AI翻译
  作者：Tway, Cathy L.; Filip, Sorin V.
  作者单位：BP; BP
• Cognitive science AI翻译
  作者：Servais, Bram
  作者单位：University of Melbourne
• Geological hydrogen AI翻译
  作者：Zhang, Hao
  作者单位：Massachusetts Institute of Technology (MIT)
• Exogenous RNA surveillance by proton-sensing TRIM25 AI翻译
  作者：Kim, Myeonghwan; Pyo, Youngjoon; Hyun, Seong-In; Jeong, Minseok; Choi, Yeon; Kim, V. Narry
  作者单位：Institute for Basic Science - Korea (IBS); Seoul National University (SNU)
  摘要：Exogenous messenger RNAs (mRNAs) require cellular machinery for delivery and translation but also encounter inhibitory factors. To investigate their regulation, we performed genome-wide CRISPR screens with in vitro-transcribed mRNAs in lipid nanoparticles (LNPs). Heparan sulfate proteoglycans (HSPGs) and vacuolar adenosine triphosphatase (V-ATPase) were identified as mediators of LNP uptake and endosomal escape, respectively. TRIM25-an RNA binding E3 ubiquitin ligase-emerged as a key suppresso...
• Beyond wear and tear at the joint AI翻译
  作者：Liu, Chuan-ju
  作者单位：Yale University
• Nuclear physics AI翻译
  作者：Awad, Yumna Gamal
  作者单位：Egyptian Knowledge Bank (EKB); Mansoura University
• Biomedicine AI翻译
  作者：Chen, Caitlyn X.
  作者单位：University of Pennsylvania
• Ectoderm barcoding reveals neural and cochlear compartmentalization AI翻译
  作者：de Haan, Sandra; He, Jingyan; Corbat, Agustin A.; Belicova, Lenka; Ratz, Michael; Vinsland, Elin; Frisen, Jonas; Kelley, Matthew W.; Andersson, Emma R.
  作者单位：Karolinska Institutet; National Institutes of Health (NIH) - USA; NIH National Institute on Deafness & Other Communication Disorders (NIDCD); Leiden University; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC; Karolinska Institutet
  摘要：Placodes and the neural crest are defining features of vertebrates. In this study, we investigate their lineages in mice using in utero approaches. We demonstrated that nanoinjection at embryonic day 7.5 targeted the ectoderm, including the future nervous system, placodes, and neural crest, allowing highly efficient manipulation of the future nervous system and inner ear. By using heritable DNA barcodes and high-throughput next-generation single-cell lineage tracing, we elucidated convergent d...
• Homogeneous-heterogeneous bifunctionality in Pd-catalyzed vinyl acetate synthesis AI翻译
  作者：Harraz, Deiaa M.; Lodaya, Kunal M.; Tang, Bryan Y.; Surendranath, Yogesh
  作者单位：Massachusetts Institute of Technology (MIT); Harvard University; Massachusetts Institute of Technology (MIT)
  摘要：Presently, mechanistic paradigms in catalysis generally posit that the active species remains either homogeneous or heterogeneous throughout the reaction. In this work, we show that a prominent industrial process, palladium (Pd)-catalyzed vinyl acetate synthesis, proceeds via interconversion of heterogeneous Pd(0) and homogeneous Pd(II) during catalysis, with each species playing a complementary role. Using electrochemical probes, we found that heterogeneous, nanoparticulate Pd(0) serves as an...