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作者：Gautam, Arya; Ghimire, Sandesh; Jha, Aashish R.
作者单位：New York University; New York University Abu Dhabi; New York University; New York University Abu Dhabi; New York University; New York University Abu Dhabi
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作者：Li, Mengyao; Jiang, Zhenhuan; Xu, Xueqiang; Wu, Xinglong; Liu, Yun; Chen, Kexuan; Liao, Yuhan; Li, Wen; Wang, Xiao; Guo, Yuqing; Zhang, Bo; Wen, Lu; Kee, Kehkooi; Tang, Fuchou
作者单位：Peking University; Changping Laboratory; National Institute of Biological Sciences, Beijing; Peking University; Tsinghua University; Tsinghua University; Hebei Agricultural University; Shanxi Medical University
摘要：In mammals, fertilized eggs undergo genome-wide epigenetic reprogramming to generate the organism. However, our understanding of epigenetic dynamics during preimplantation development at single-cell resolution remains incomplete. Here, we developed scNanoATAC-seq2, a single-cell assay for transposase-accessible chromatin using long-read sequencing for scarce samples. We present a detailed chromatin accessibility landscape of mouse preimplantation development, revealing distinct chromatin signa...
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作者：Robles-Gil, Alexa
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作者：Cornwall, Warren
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作者：Dang, Gisa; Perrin, Christophe; Furin, Jennifer
作者单位：Harvard University; Harvard Medical School
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作者：Aggarwal, Pradhi; Brandon, Alec; Goldszmidt, Ariel; Holz, Justin; List, John A.; Muir, Ian; Sun, Gregory; Yu, Thomas
作者单位：Massachusetts Institute of Technology (MIT); Johns Hopkins University; University of Chicago; University of Michigan System; University of Michigan; Washington University (WUSTL); Yale University
摘要：Prior research on racial profiling has found that in encounters with law enforcement, minorities are punished more severely than white civilians. Less is known about the causes of these encounters and their implications for our understanding of racial profiling. Using high-frequency location data of rideshare drivers in Florida (N = 222,838 individuals), we estimate the effect of driver race on citations and fines for speeding using 19.3 million location pings. Compared with a white driver tra...
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作者：Cohen, Jon
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作者：Pizzirani, Stefania
作者单位：University of Fraser Valley; University of Fraser Valley
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作者：Zhu, Zhenggang; Gong, Rong; Rodriguez, Vicente; Quach, Kathleen T.; Chen, Xinyu; Sternson, Scott M.
作者单位：University of California System; University of California San Diego; Howard Hughes Medical Institute; Howard Hughes Medical Institute; University of California System; University of California San Diego; Beijing Normal University; Chinese Institute for Brain Research, Beijing
摘要：Hedonic eating is defined as food consumption driven by palatability without physiological need. However, neural control of palatable food intake is poorly understood. We discovered that hedonic eating is controlled by a neural pathway from the peri-locus ceruleus to the ventral tegmental area (VTA). Using photometry-calibrated optogenetics, we found that VTA dopamine (VTADA) neurons encode palatability to bidirectionally regulate hedonic food consumption. VTADA neuron responsiveness was suppr...
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作者：Castiglione, Gianni M.; Chen, Xin; Xu, Zhenhua; Dbouk, Nadir H.; Bose, Anamika A.; Carmona-Berrio, David; Chi, Emiliana E.; Zhou, Lingli; Boronina, Tatiana N.; Cole, Robert N.; Wu, Shirley; Liu, Abby D.; Liu, Thalia D.; Lu, Haining; Kalbfleisch, Ted; Rinker, David; Rokas, Antonis; Ortved, Kyla; Duh, Elia J.
作者单位：Vanderbilt University; Vanderbilt University; Johns Hopkins University; Vanderbilt University; Johns Hopkins University; University of Kentucky; University of Pennsylvania
摘要：Horses are among nature's greatest athletes, yet the ancestral molecular adaptations fueling their energy demands are poorly understood. Within a clinically important pathway regulating redox and metabolic homeostasis (NRF2/KEAP1), we discovered an ancient mutation-conserved in all extant equids-that increases mitochondrial respiration while decreasing tissue-damaging oxidative stress. This mutation is a de novo premature opal stop codon in KEAP1 that is translationally recoded into a cysteine...
