Science

最新文章

• Archaea go multicellular under pressure AI翻译
  作者：Pillai, Eva K.; Brunet, Thibaut
  作者单位：European Molecular Biology Laboratory (EMBL); European Molecular Biology Laboratory (EMBL); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Pasteur Network; Universite Paris Cite; Institut Pasteur Paris
• Osteoarthritis treatment via the GLP-1-mediated gut-joint axis targets intestinal FXR signaling AI翻译
  作者：Yang, Yuanheng; Hao, Cong; Jiao, Tingying; Yang, Zidan; Li, Hui; Zhang, Yuqing; Zhang, Weiya; Doherty, Michael; Sun, Chuying; Yang, Tuo; Li, Jiatian; Wu, Jing; Zhang, Mengjiao; Wang, Yilun; Xie, Dongxing; Wang, Tingjian; Wang, Ning; Huang, Xi; Li, Changjun; Gonzalez, Frank J.; Wei, Jie; Xie, Cen; Zeng, Chao; Lei, Guanghua
  作者单位：Central South University; Central South University; Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; Fudan University; Central South University; Central South University; Central South University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard Medical School; University of Nottingham; Nanjing University of Chinese Medicine; Central South University; Central South University; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; Central South University; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Central South University; Furong Laboratory; Central South University
  摘要：Whether a gut-joint axis exists to regulate osteoarthritis is unknown. In two independent cohorts, we identified altered microbial bile acid metabolism with reduced glycoursodeoxycholic acid (GUDCA) in osteoarthritis. Suppressing farnesoid X receptor (FXR)-the receptor of GUDCA-alleviated osteoarthritis through intestine-secreted glucagon-like peptide 1 (GLP-1) in mice. GLP-1 receptor blockade attenuated these effects, whereas GLP-1 receptor activation mitigated osteoarthritis. Osteoarthritis ...
• Dancing with the cells: How acoustically levitating a diamond enabled a redesign of biotech automation AI翻译
  作者：Cox, Luke
• mRNA binding proteins join the longevity pipeline: Rebuilding muscle through the power of mRNA binding protein therapeutics AI翻译
  作者：Abbadi, Dounia
  作者单位：New York University
• Judge blocks FDA on lab tests AI翻译
  作者：Brainard, Jeffrey
• Aquatic genetics AI翻译
  作者：Li, Fengbo
• Tissue-like multicellular development triggered by mechanical compression in archaea AI翻译
  作者：Rados, Theopi; Leland, Olivia S.; Escudeiro, Pedro; Mallon, John; Andre, Katherine; Caspy, Ido; von Kuegelgen, Andriko; Stolovicki, Elad; Nguyen, Sinead; Patop, Ines Lucia; Rangel, L. Thiberio; Kadener, Sebastian; Renner, Lars D.; Thiel, Vera; Soen, Yoav; Bharat, Tanmay A. M.; Alva, Vikram; Bisson, Alex
  作者单位：Brandeis University; MRC Laboratory Molecular Biology; Weizmann Institute of Science; Massachusetts Institute of Technology (MIT); Leibniz Association; Leibniz Institut fur Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ)
  摘要：The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely in bacteria, and only once in archaea. We show that uniaxial compression induces clonal multicellularity in haloarchaea, forming tissue-like structures. These archaeal tissues are mechanically and molecularly distinct from their unicellular lifestyle, mimicking several eukaryotic features. Archaeal tissues undergo a multinucleate stage followed by tubulin-independent cellularization, or...
• Probe that observed 2 billion stars ends mission AI翻译
  作者：Brainard, Jeffrey
• Integrating multiple evidence streams to understand insect biodiversity change AI翻译
  作者：Cooke, Rob; Outhwaite, Charlotte L.; Bladon, Andrew J.; Millard, Joseph; Rodger, James G.; Dong, Zhaoke; Dyer, Ellie E.; Edney, Siobhan; Murphy, John F.; Dicks, Lynn V.; Hui, Cang; Jones, J. Iwan; Newbold, Tim; Purvis, Andy; Roy, Helen E.; Woodcock, Ben A.; Isaac, Nick J. B.
  作者单位：UK Centre for Ecology & Hydrology (UKCEH); University of London; University College London; Zoological Society of London; University of Cambridge; University of Reading; Natural History Museum London; Stellenbosch University; Qingdao Agricultural University; University of London; Queen Mary University London; Imperial College London; University of Exeter
  摘要：Insects dominate animal species diversity yet face many threats from anthropogenic drivers of change. Many features of insect ecology make them a challenging group, and the fragmented state of knowledge compromises our ability to make general statements about their status. In this Review, we discuss the challenges of assessing insect biodiversity change. We describe how multiple lines of evidence-time series, spatial comparisons, experiments, and expert opinion-can be integrated to provide a s...
• The Instability of Truth: Brainwashing, Mind Control, and Hyper-Persuasion AI翻译
  作者：Joice, Katie
  作者单位：University of London