作者：Hu, Yutong
作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS
作者：Midavaine, Elora; Moraes, Beatriz C.; Benitez, Jorge; Rodriguez, Sian R.; Braz, Joao M.; Kochhar, Nathan P.; Eckalbar, Walter L.; Tian, Lin; Domingos, Ana I.; Pintar, John E.; Basbaum, Allan I.; Kashem, Sakeen W.
作者单位：University of California System; University of California San Francisco; Max Planck Society; University of Oxford; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; University of California System; University of California San Francisco; US Department of Veterans Affairs; Veterans Health Administration (VHA)
摘要：T cells have emerged as orchestrators of pain amplification, but the mechanism by which T cells control pain processing is unresolved. We found that regulatory T cells (T-reg cells) could inhibit nociception through a mechanism that was not dependent on their ability to regulate immune activation and tissue repair. Site-specific depletion or expansion of meningeal T-reg cells (mT(reg) cells) in mice led to female-specific and sex hormone-dependent modulation of mechanical sensitivity. Specific...
作者：Hua, Yi; Tay, Nicholas E. S.; Ye, Xuanjia; Owen, Jeremy A.; Liu, Hengyuan; Thompson, Robert E.; Muir, Tom W.
作者单位：Princeton University
摘要：Protein engineering through the ligation of polypeptide fragments has proven enormously powerful for studying biochemical processes. In general, this strategy necessitates a final protein-folding step, constraining the types of systems amenable to the approach. Here, we report a method that allows internal regions of target proteins to be replaced in a single operation. Conceptually, our system is analogous to a DNA transposition reaction but uses orthogonal pairs of engineered split inteins t...
作者：Ortiz Alvarez De La Campa, Melanie
作者单位：Brown University
作者：Wang, Zhen
作者单位：Shandong University of Finance & Economics
