Tissue-like multicellular development triggered by mechanical compression in archaea

• 成果类型: Article
• 署名作者: Rados, Theopi; Leland, Olivia S.; Escudeiro, Pedro; Mallon, John; Andre, Katherine; Caspy, Ido; von Kuegelgen, Andriko; Stolovicki, Elad; Nguyen, Sinead; Patop, Ines Lucia; Rangel, L. Thiberio; Kadener, Sebastian; Renner, Lars D.; Thiel, Vera; Soen, Yoav; Bharat, Tanmay A. M.; Alva, Vikram; Bisson, Alex
• 署名单位: Brandeis University; MRC Laboratory Molecular Biology; Weizmann Institute of Science; Massachusetts Institute of Technology (MIT); Leibniz Association; Leibniz Institut fur Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ)
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-12389
• DOI: 10.1126/science.adu0047
• 发表日期: 2025-04-04
• 页码: 109-115
• 关键词: packing

摘要

The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely in bacteria, and only once in archaea. We show that uniaxial compression induces clonal multicellularity in haloarchaea, forming tissue-like structures. These archaeal tissues are mechanically and molecularly distinct from their unicellular lifestyle, mimicking several eukaryotic features. Archaeal tissues undergo a multinucleate stage followed by tubulin-independent cellularization, orchestrated by active membrane tension at a critical cell size. After cellularization, tissue junction elasticity becomes akin to that of animal tissues, giving rise to two cell types-peripheral (Per) and central scutoid (Scu) cells-with distinct actin and protein glycosylation polarity patterns. Our findings highlight the potential convergent evolution of a biophysical mechanism in the emergence of multicellular systems across domains of life.