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作者：Kemp, R. Scott; Lyman, Edwin S.; Deinert, Mark R.; Garwin, Richard L.; von Hippel, Frank N.
作者单位：Massachusetts Institute of Technology (MIT); Colorado School of Mines; International Business Machines (IBM); IBM USA; Princeton University
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作者：Mallory, Caitlin S.; Widloski, John; Foster, David J.
作者单位：University of California System; University of California Berkeley
摘要：The mechanisms by which the brain replays neural activity sequences remain unknown. Recording from large ensembles of hippocampal place cells in freely behaving rats, we observed that replay content is strictly organized over multiple timescales and governed by self-avoidance. After movement cessation, replays avoided the animal's previous path for 3 seconds. Chains of replays avoided self-repetition over a shorter timescale. We used a continuous attractor model of neural activity to demonstra...
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作者：Markert, Jonathan W.; Soffers, Jelly H.; Farnung, Lucas
作者单位：Harvard University; Harvard Medical School; University of Missouri System; University of Missouri Kansas City
摘要：During transcription, RNA polymerase II traverses through chromatin, and posttranslational modifications including histone methylations mark regions of active transcription. Histone protein H3 lysine 36 trimethylation (H3K36me3), which is established by the histone methyltransferase SET domain containing 2 (SETD2), suppresses cryptic transcription, regulates splicing, and serves as a binding site for transcription elongation factors. The mechanism by which the transcription machinery coordinat...
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作者：Marshall, Lisa
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作者：Pinglay, Sudarshan; Lalanne, Jean-Benoit; Daza, Riza M.; Kottapalli, Sanjay; Quaisar, Faaiz; Koeppel, Jonas; Garge, Riddhiman K.; Li, Xiaoyi; Lee, David S.; Shendure, Jay
作者单位：University of Washington; University of Washington Seattle; Wellcome Trust Sanger Institute; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute
摘要：Studying the functional consequences of structural variants (SVs) in mammalian genomes is challenging because (i) SVs arise much less commonly than single-nucleotide variants or small indels and (ii) methods to generate, map, and characterize SVs in model systems are underdeveloped. To address these challenges, we developed Genome-Shuffle-seq, a method that enables the multiplex generation and mapping of thousands of SVs (deletions, inversions, translocations, and extrachromosomal circles) thr...
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作者：Brainard, Jeffrey
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作者：Brainard, Jeffrey
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作者：Zicho, Krisztian; Balog, Boldizsar Zsolt; Sebesteny, Reka Z.; Brunner, Janos; Takacs, Virag; Barth, Albert M.; Seng, Charlotte; Orosz, Aron; Aliczki, Mano; Sebok, Hunor; Mikics, Eva; Foeldy, Csaba; Szabadics, Janos; Nyiri, Gabor
作者单位：HUN-REN; HUN-REN Institute of Experimental Medicine; Semmelweis University; Pazmany Peter Catholic University; HUN-REN; HUN-REN Institute of Experimental Medicine; University of Zurich; HUN-REN; HUN-REN Institute of Experimental Medicine
摘要：Rewards are essential for motivation, decision-making, memory, and mental health. We identified the subventricular tegmental nucleus (SVTg) as a brainstem reward center. In mice, reward and its prediction activate the SVTg, and SVTg stimulation leads to place preference, reduced anxiety, and accumbal dopamine release. Mice self-stimulate the SVTg, which can also be activated directly by the neocortex, resulting in effective inhibition of the lateral habenula, a region associated with depressio...
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作者：Brainard, Jeffrey
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作者：Clery, Daniel
