-
作者：Jobin, Katarzyna; Seetharama, Deeksha; Ruettger, Lennart; Fenton, Chloe; Kharybina, Ekaterina; Wirsching, Annerose; Huang, Anfei; Knoepper, Konrad; Kaisho, Tsuneyasu; Busch, Dirk H.; Vaeth, Martin; Saliba, Antoine-Emmanuel; Graw, Frederik; Pulfer, Alain; Gonzalez, Santiago F.; Zehn, Dietmar; Liang, Yinming; Ugur, Milas; Gasteiger, Georg; Kastenmueller, Wolfgang
作者单位：University of Wurzburg; Max Planck Society; Wakayama Medical University; Technical University of Munich; Helmholtz Association; Helmholtz-Center for Infection Research; University of Wurzburg; University of Erlangen Nuremberg; University of Erlangen Nuremberg; Universita della Svizzera Italiana; Technical University of Munich; Henan Medical University
摘要：T cell priming is characterized by an initial activation phase that involves stable interactions with dendritic cells (DCs). How activated T cells receive the paracrine signals required for their differentiation once they have disengaged from DCs and resumed their migration has been unclear. We identified a distinct priming phase that favors CD8 T cells expressing receptors with high affinity for antigen. CXCR3 expression by CD8 T cells was required for their hours-long reengagement with DCs i...
-
作者：Li, Xuan; Fu, Qizi; Wang, Qilin
作者单位：University of Technology Sydney
-
作者：Servick, Kelly
-
作者：Midavaine, Elora; Moraes, Beatriz C.; Benitez, Jorge; Rodriguez, Sian R.; Braz, Joao M.; Kochhar, Nathan P.; Eckalbar, Walter L.; Tian, Lin; Domingos, Ana I.; Pintar, John E.; Basbaum, Allan I.; Kashem, Sakeen W.
作者单位：University of California System; University of California San Francisco; Max Planck Society; University of Oxford; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; University of California System; University of California San Francisco; US Department of Veterans Affairs; Veterans Health Administration (VHA)
摘要：T cells have emerged as orchestrators of pain amplification, but the mechanism by which T cells control pain processing is unresolved. We found that regulatory T cells (T-reg cells) could inhibit nociception through a mechanism that was not dependent on their ability to regulate immune activation and tissue repair. Site-specific depletion or expansion of meningeal T-reg cells (mT(reg) cells) in mice led to female-specific and sex hormone-dependent modulation of mechanical sensitivity. Specific...
-
作者：Servais, Bram
作者单位：University of Melbourne
-
作者：Zhang, Hao
作者单位：Massachusetts Institute of Technology (MIT)
-
作者：Samaniego, Luis
作者单位：Helmholtz Association; Helmholtz Center for Environmental Research (UFZ); University of Potsdam
-
作者：Cohen, Jon
-
作者：Canesso, Maria Cecilia Campos; de Castro, Tiago Bruno Rezende; Nakandakari-Higa, Sandra; Lockhart, Ainsley; Luehr, Julia; Bortolatto, Juliana; Parsa, Roham; Esterhazy, Daria; Lyu, Mengze; Liu, Tian-Tian; Murphy, Kenneth M.; Sonnenberg, Gregory F.; Reis, Bernardo S.; Victora, Gabriel D.; Mucida, Daniel
作者单位：Rockefeller University; Rockefeller University; University of Chicago; Cornell University; Weill Cornell Medicine; Washington University (WUSTL); Rockefeller University; Howard Hughes Medical Institute
摘要：The intestinal immune system must concomitantly tolerate food and commensals and protect against pathogens. Antigen-presenting cells (APCs) orchestrate these immune responses by presenting luminal antigens to CD4+ T cells and inducing their differentiation into regulatory (peripheral regulatory T cell) or inflammatory [T helper (Th) cell] subsets. We used a proximity labeling method (LIPSTIC) to identify APCs that presented dietary antigens under tolerizing and inflammatory conditions and to u...
-
作者：Gibbons, Ann
