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作者：Sebek, Frantisek
作者单位：Brno University of Technology
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作者：Pai, Shreyas V.; Humphrey, Parris T.; Simonet, Camille; Kosheleva, Katya; Limdi, Anurag; Desai, Michael M.
作者单位：Harvard University; Harvard University; Harvard University; Harvard Medical School; University of Edinburgh; Harvard University
摘要：Understanding the evolutionary mechanisms that maintain sex despite its direct costs is a long-standing challenge. Previous work has shown that sexual recombination can accelerate adaptation, in part by separating beneficial mutations from deleterious hitchhikers. However, earlier studies focused on effects of sex in a constant environment. We show that recombination provides an advantage during changing conditions in promoting the evolution of generalist phenotypes by reducing pleiotropic cos...
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作者：Yang, Jiarui; Pei, Zhihao; Ye, Bo-Chao; Li, Wen-Hao; Yan, Han; Luan, Deyan; Wang, Dingsheng; Lou, Xiong Wen (David)
作者单位：City University of Hong Kong; Tsinghua University; Northeastern University - China; Chinese Academy of Sciences; University of Science & Technology of China, CAS
摘要：Conventional thermal propane dehydrogenation (PDH) faces several notable drawbacks, including high energy requirements, coking-induced catalyst deactivation, and the need for product separation. An electrocatalytic approach, using self-assembled ionic liquid (IL)-tin dioxide (SnO2) hollow spheres as the electrocatalyst, enables efficient PDH at ambient temperature. In this process, bromopropane formed in the anolyte from propane reacts with hydroxyl anions from the cathode to yield propene. Th...
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作者：Chao, Yu-Kai; Wu, Michelle; Gong, Qiyu; Chen, Fei
作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University
摘要：Understanding how cells make decisions over time requires the ability to link past molecular states to future phenotypic outcomes. We present TimeVault, a genetically encoded system that records and stores transcriptomes within living mammalian cells for future readout. TimeVault leverages engineered vault particles that capture messenger RNA through polyadenosine [poly (A)]-binding protein. We demonstrate that the transcriptome stored by TimeVaults is stable in living cells for more than 7 da...
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作者：Faherty, Jackie
作者单位：American Museum of Natural History (AMNH)
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作者：Ling, Yick Hin; Liang, Chloe; Wang, Sixiang; Wu, Carl
作者单位：Johns Hopkins University; Johns Hopkins University; Johns Hopkins Medicine
摘要：Eukaryotic gene expression is orchestrated by RNA polymerases (RNAPI, II, and III) and associated factors, yet their real-time dynamics remain obscure. Using single-molecule tracking in living yeast, we quantified the kinetics of 58 proteins encompassing three RNAP machineries. RNAPI and RNAPIII preinitiation complexes (PICs) engage in long-lived chromatin interactions, contrasting with transient RNAPII PICs. We further report kinetics of RNAPII-associated factors for elongation, histone modif...
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作者：Wade, Lizzie
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作者：Anstett, Daniel N.; Anstett, Julia; Sheth, Seema N.; Moxley, Dylan R.; Branch, Haley A.; Jahani, Mojtaba; Huang, Kaichi; Todesco, Marco; Jordan, Rebecca; Lazaro-Guevara, Jose Miguel; Rieseberg, Loren H.; Angert, Amy L.
作者单位：University of British Columbia; University of British Columbia; Cornell University; Cornell University; Michigan State University; Michigan State University; Michigan State University; University of British Columbia; University of British Columbia; North Carolina State University; University of British Columbia; Yale University; Sun Yat Sen University; University of British Columbia; University of British Columbia Okanagan; Commonwealth Scientific & Industrial Research Organisation (CSIRO); CSIRO Environment; McGill University; McGill University; University of British Columbia
摘要：Populations that are declining as a result of climate change may need to evolve to persist. Although evolutionary rescue has been demonstrated in theory and in the laboratory, its relevance to natural populations facing climate change remains unknown. Here we link rapid evolution and population dynamics in scarlet monkeyflower, Mimulus cardinalis, during exceptional drought. We leverage whole-genome sequencing across 55 populations to identify climate-associated loci. Simultaneously we track d...
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作者：Dogra-Freitag, Aashima
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作者：Ervijn, Lien; Sanders, Niek N.
作者单位：Ghent University; Ghent University
