作者：Hu, Xiao-Pan; Brahmantio, Bayu; Bartoszek, Krzysztof; Lercher, Martin J.
作者单位：Heinrich Heine University Dusseldorf; Linkoping University
摘要：The arrangement of genes along bacterial chromosomes influences their expression through growth rate-dependent gene copy number changes during DNA replication. Although translation- and transcription-related genes often cluster near the origin of replication, the extent of positional biases across gene families remains unclear. We hypothesized that natural selection broadly favors specific chromosomal positions to optimize growth rate-dependent expression. Analyzing 910 bacterial species and p...
作者：Liu, Yajing; Zhang, Yang; Wang, Jing; Yang, Chao; Wang, Hongguang; MacManus-Driscoll, Judith L.; Yang, Hao; van Aken, Peter A.; Li, Weiwei; Nan, Ce-Wen
作者单位：Nanjing University of Aeronautics & Astronautics; Nanjing University of Aeronautics & Astronautics; Nanjing University of Aeronautics & Astronautics; Max Planck Society; University of Cambridge; Tsinghua University
摘要：Electrostatic dielectric capacitors with ultrahigh power densities are sought after for advanced electronic and electrical systems owing to their ultrafast charge-discharge capability. However, low energy density resulting from low breakdown strength and suppressed polarization still remains a daunting challenge for practical applications. We propose a microstructural strategy with dendritic nanopolar (DNP) regions self-assembled into an insulator, which simultaneously enhances breakdown stren...
作者：Canizares-Esguerra, Jorge
作者单位：University of Texas System; University of Texas Austin
作者：Opachaloemphan, Comzit; He, Sheng Yang
作者单位：Duke University; Duke University; Howard Hughes Medical Institute
作者：Walker, Emily M.; Pearson, Gemma L.; Lawlor, Nathan; Stendahl, Ava M.; Lietzke, Anne; Sidarala, Vaibhav; Zhu, Jie; Stromer, Tracy; Reck, Emma C.; Li, Jin; Levi-D'Ancona, Elena; Pasmooij, Mabelle B.; Hubers, Dre L.; Renberg, Aaron; Mohamed, Kawthar; Parekh, Vishal S.; Zhang, Irina X.; Thompson, Benjamin; Zhang, Deqiang; Ware, Sarah A.; Haataja, Leena; Qi, Nathan; Parker, Stephen C. J.; Arvan, Peter; Yin, Lei; Kaufman, Brett A.; Satin, Leslie S.; Sussel, Lori; Stitzel, Michael L.; Soleimanpour, Scott A.
作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Jackson Laboratory; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Michigan System; University of Michigan; University of Colorado System; University of Colorado Anschutz Medical Campus; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Ann Arbor Healthcare System
摘要：Mitochondrial damage is a hallmark of metabolic diseases, including diabetes, yet the consequences of compromised mitochondria in metabolic tissues are often unclear. In this work, we report that dysfunctional mitochondrial quality control engages a retrograde (mitonuclear) signaling program that impairs cellular identity and maturity in beta cells, hepatocytes, and brown adipocytes. Targeted deficiency throughout the mitochondrial quality control pathway, including genome integrity, dynamics,...
