Science

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• Computational design of serine hydrolases AI翻译
  作者：Lauko, Anna; Pellock, Samuel J.; Sumida, Kiera H.; Anishchenko, Ivan; Juergens, David; Ahern, Woody; Jeung, Jihun; Shida, Alexander F.; Hunt, Andrew; Kalvet, Indrek; Norn, Christoffer; Humphreys, Ian R.; Jamieson, Cooper; Krishna, Rohith; Kipnis, Yakov; Kang, Alex; Brackenbrough, Evans; Bera, Asim K.; Sankaran, Banumathi; Houk, K. N.; Baker, David
  作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle; University of California System; University of California Los Angeles
  摘要：The design of enzymes with complex active sites that mediate multistep reactions remains an outstanding challenge. With serine hydrolases as a model system, we combined the generative capabilities of RFdiffusion with an ensemble generation method for assessing active site preorganization at each step in the reaction to design enzymes starting from minimal active site descriptions. Experimental characterization revealed catalytic efficiencies (k(cat)/K-m) up to 2.2 x 10(5) M-1 s(-1) and crystal...
• Cracking the failure of lithium batteries AI翻译
  作者：Nanda, Jagjit; Kalnaus, Sergiy
  作者单位：Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Stanford University; United States Department of Energy (DOE); Oak Ridge National Laboratory
• Asymmetric amination of alkyl radicals with two minimally different alkyl substituents AI翻译
  作者：Zhang, Yu-Feng; Wang, Biao; Chen, Zheng; Liu, Ji-Ren; Yang, Ning-Yuan; Xiang, Jin-Min; Liu, Juan; Gu, Qiang-Shuai; Hong, Xin; Liu, Xin-Yuan
  作者单位：Southern University of Science & Technology; Southern University of Science & Technology; Southern University of Science & Technology; Zhejiang University
  摘要：Differentiating between similar alkyl groups is a major challenge in asymmetric catalysis. Achieving enantiocontrol over unactivated prochiral alkyl radicals is even more difficult owing to their high reactivity and limited interactions with chiral catalysts. In this study, we report a copper-catalyzed asymmetric amination of unactivated prochiral secondary alkyl radicals, using specifically designed chiral anionic multidentate ligands in a radical substitution reaction. This approach efficien...
• Disposal of anesthetics threatens ecosystems AI翻译
  作者：Liu, Chao; Li, Ping; Liu, Dahai
  作者单位：Ministry of Natural Resources of the People's Republic of China; First Institute of Oceanography, Ministry of Natural Resources; Civil Aviation Flight University of China; Renmin University of China
• New German high-tech ministry AI翻译
  作者：Chakradhar, Shraddha
• Casz1 is required for both inner hair cell fate stabilization and outer hair cell survival AI翻译
  作者：Sun, Yuwei; Ren, Minhui; Zhang, Yu; Li, Shuting; Luo, Zhengnan; Sun, Suhong; He, Shunji; Wang, Guangqin; Zhang, Di; Mansour, Suzanne L.; Song, Lei; Liu, Zhiyong
  作者单位：Chinese Academy of Sciences; Center for Excellence in Brain Science and Intelligence Technology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Utah System of Higher Education; University of Utah; Shanghai Center for Brain Science & Brain-Inspired Technology
  摘要：Cochlear inner hair cells (IHCs) and outer hair cells (OHCs) require different transcription factors for their cell fate stabilization and survival, which suggests that separate mechanisms are involved. In this study, we found that the transcription factor Casz1 is crucial for early IHC fate consolidation and for OHC survival during mouse development. Loss of Casz1 resulted in transdifferentiation of IHCs into OHCs, without affecting OHC production. However, long-term OHC survival was compromi...
• EVOLUTION Cat domestication tied to ancient Egyptian cult AI翻译
  作者：Grimm, David
• Dendritic arbors structure memories AI翻译
  作者：Groisman, Ayelen I.; Letzkus, Johannes J.
  作者单位：University of Freiburg; University of Freiburg; University of Freiburg
• PLANT BIOLOGY Scientists identify structure that controls seed size AI翻译
  作者：Stokstad, Erik
• Mutter Museum director ousted AI翻译
  作者：Chakradhar, Shraddha