作者：Liu, Chao; Li, Ping; Liu, Dahai
作者单位：Ministry of Natural Resources of the People's Republic of China; First Institute of Oceanography, Ministry of Natural Resources; Ocean University of China; Renmin University of China
作者：Schroeder, Frank C.
作者单位：Cornell University; Boyce Thompson Institute for Plant Research; Cornell University
作者：Dildine, Troy Christopher
作者单位：Stanford University
作者：Marand, Alexandre P.; Jiang, Luguang; Gomez-Cano, Fabio; Minow, Mark A. A.; Zhang, Xuan; Mendieta, John P.; Luo, Ziliang; Bang, Sohyun; Yan, Haidong; Meyer, Cullan; Schlegel, Luca; Johannes, Frank; Schmitz, Robert J.
作者单位：University System of Georgia; University of Georgia; University of Michigan System; University of Michigan; University System of Georgia; University of Georgia; Technical University of Munich
摘要：Gene expression and complex phenotypes are determined by the activity of cis-regulatory elements. However, an understanding of how extant genetic variants affect cis regulation remains limited. Here, we investigated the consequences of cis-regulatory diversity using single-cell genomics of more than 0.7 million nuclei across 172 Zea mays (maize) inbreds. Our analyses pinpointed cis-regulatory elements distinct to domesticated maize and revealed how historical transposon activity has shaped the...
作者：Tutolo, Benjamin M.; Hausrath, Elisabeth M.; Kite, Edwin S.; Rampe, Elizabeth B.; Bristow, Thomas F.; Downs, Robert T.; Treiman, Allan; Peretyazhko, Tanya S.; Thorpe, Michael T.; Grotzinger, John P.; Roberts, Amelie L.; Archer, P. Douglas; Des Marais, David J.; Blake, David F.; Vaniman, David T.; Morrison, Shaunna M.; Chipera, Steve; Hazen, Robert M.; Morris, Richard V.; Tu, Valerie M.; Simpson, Sarah L.; Pandey, Aditi; Yen, Albert; Larter, Stephen R.; Craig, Patricia; Castle, Nicholas; Ming, Douglas W.; Meusburger, Johannes M.; Fraeman, Abigail A.; Burtt, David G.; Franz, Heather B.; Sutter, Brad; Clark, Joanna V.; Rapin, William; Bridges, John C.; Loche, Matteo; Gasda, Patrick; Frydenvang, Jens; Vasavada, Ashwin R.
作者单位：University of Calgary; Nevada System of Higher Education (NSHE); University of Nevada Las Vegas; University of Chicago; National Aeronautics & Space Administration (NASA); NASA Johnson Space Center; National Aeronautics & Space Administration (NASA); NASA Ames Research Center; University of Arizona; Universities Space Research Association (USRA); National Aeronautics & Space Administration (NASA); NASA Johnson Space Center; University System of Maryland; University of Maryland College Park; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; California Institute of Technology; Imperial College London; Carnegie Institution for Science; Rutgers University System; Rutgers University New Brunswick; Texas State University System; Texas State University San Marcos; National Aeronautics & Space Administration (NASA); NASA Johnson Space Center; California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Centre National de la Recherche Scientifique (CNRS); University of Leicester; United States Department of Energy (DOE); Los Alamos National Laboratory; University of Copenhagen
摘要：Ancient Mars had surface liquid water and a dense carbon dioxide (CO2)-rich atmosphere. Such an atmosphere would interact with crustal rocks, potentially leaving a mineralogical record of its presence. We analyzed the composition of an 89-meter stratigraphic section of Gale crater, Mars, using data collected by the Curiosity rover. An iron carbonate mineral, siderite, occurs in abundances of 4.8 to 10.5 weight %, colocated with highly water-soluble salts. We infer that the siderite formed in w...
作者：Gandin, Valentina; Kim, Jun; Yang, Liang-Zhong; Lian, Yumin; Kawase, Takashi; Hu, Amy; Rokicki, Konrad; Fleishman, Greg; Tillberg, Paul; Castrejon, Alejandro Aguilera; Stringer, Carsen; Preibisch, Stephan; Liu, Zhe J.
摘要：Limited color channels in fluorescence microscopy have long constrained spatial analysis in biological specimens. We introduce cycle hybridization chain reaction (cycleHCR), a method that integrates multicycle DNA barcoding with HCR to overcome this limitation. cycleHCR enables highly multiplexed imaging of RNA and proteins using a unified barcode system. Whole-embryo transcriptomics imaging achieved precise three-dimensional gene expression and cell fate mapping across a specimen depth of sim...
