Science

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• RNA-mediated CRISPR-Cas13 inhibition through crRNA structural mimicry AI翻译
  作者：Hayes, Victoria M.; Zhang, Jun-Tao; Katz, Mark A.; Li, Yuelong; Kocsis, Benjamin; Brinkley, David M.; Jia, Ning; Meeske, Alexander J.
  作者单位：University of Washington; University of Washington Seattle; Southern University of Science & Technology; Southern University of Science & Technology
  摘要：To circumvent CRISPR-Cas immunity, phages express anti-CRISPR factors that inhibit the expression or activities of Cas proteins. Whereas most anti-CRISPRs described to date are proteins, recently described small RNAs called RNA anti-CRISPRs (rAcrs) have sequence homology to CRISPR RNAs (crRNAs) and displace them from cognate Cas nucleases. In this work, we report the discovery of rAcrVIA1-a plasmid-encoded small RNA that inhibits the RNA-targeting CRISPR-Cas13 system in its natural host, Liste...
• A well-connected Earth: The science and conservation of organismal movement AI翻译
  作者：Brodie, Jedediah F.; Gonzalez, Andrew; Mohd-Azlan, Jayasilan; Nelson, Cara R.; Tabor, Gary; Vasudev, Divya; Zeller, Katherine A.; Fletcher, Robert J., Jr.
  作者单位：University of Montana System; University of Montana; University of Montana System; University of Montana; University of Malaysia Sarawak; McGill University; University of Montana System; University of Montana; Cornell University; United States Department of Agriculture (USDA); United States Forest Service; State University System of Florida; University of Florida; University of Cambridge
  摘要：Global biodiversity targets focus on landscape and seascape connectivity as a foundational component of biodiversity conservation, including networks of connected protected areas. Recent advances allow the measurement and prediction of organismal movements at multiple scales. We provide a definition of connectivity that links movement to persistence and ecological function. Connectivity science can guide planning for biodiversity, ecosystem services, ecological restoration, and climate adaptat...
• SPACE Astronomers claim Chinese star catalog is world's oldest AI翻译
  作者：Sokol, Joshua
• Bottom-up reconstruction of functional death fold signalosomes reveals a requirement for polymer stability and avidity AI翻译
  作者：Lichtenstein, Mauriz A.; Cao, Fakun; Lobnow, Finn; Dirvanskyte, Paulina; Weyhenmeyer, Daniel; Kulesza, Anna; Ziska, Elke; Halfmann, Randal; Taylor, Marcus J.
  作者单位：Max Planck Society; University of Kansas; Stowers Institute for Medical Research
  摘要：Protein polymer scaffolds composed of death fold (DF) proteins are critical to the formation of signalosomes in immune signaling. The biophysical properties that these polymeric scaffolds require for signal transduction are not clearly defined. Here, we engineered single-component DF signalosomes. We found that functionality depends on the stability provided by the DF polymer, which could also be achieved with a bacterial DF domain, a synthetic filament-forming domain, and amyloid-like sequenc...
• THE FOG OF WAR AI翻译
  作者：Normile, Dennis
• Structural basis for strychnine activation of human bitter taste receptor TAS2R46( vol 377, pg 1298, 2022) AI翻译
  作者：Thorp, H. Holden
• So Very Small: How Humans Discovered the Microcosmos, Defeated Germs-and May Still Lose the War Against Infectious Disease AI翻译
  作者：Smith, Tara C.
  作者单位：University System of Ohio; Kent State University; Kent State University Salem; Kent State University Kent
• Base-modified nucleotides mediate immune signaling in bacteria AI翻译
  作者：Zeng, Zhifeng; Hu, Zeyu; Zhao, Ruiliang; Rao, Jikai; Mestre, Mario Rodriguez; Liu, Yanqiu; Liu, Shunhang; Feng, Hao; Chen, Yu; He, Huan; Chen, Nuo; Zheng, Jinshui; Peng, Donghai; Luo, Min; She, Qunxin; Pinilla-Redondo, Rafael; Han, Wenyuan
  作者单位：Huazhong Agricultural University; Hubei Hongshan Laboratory; Huazhong Agricultural University; University of Copenhagen; National University of Singapore; Huazhong Agricultural University; Huazhong Agricultural University; Shandong University
  摘要：Signaling from pathogen sensing to effector activation is a fundamental principle of cellular immunity. Whereas cyclic (oligo)nucleotides have emerged as key signaling molecules, the existence of other messengers remains largely unexplored. In this study, we reveal a bacterial antiphage system that mediates immune signaling through nucleobase modification. Immunity is triggered by phage nucleotide kinases, which, combined with the system-encoded adenosine deaminase, produce deoxyinosine tripho...
• Life on an exoplanet? Not so fast AI翻译
  作者：Servick, Kelly
• GENETICS Last of Mendel's seven genetic riddles solved AI翻译
  作者：Stokstad, Erik