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作者：Insco, Megan L.; Abraham, Brian J.; Dubbury, Sara J.; Kaltheuner, Ines H.; Dust, Sofia; Wu, Constance; Chen, Kevin Y.; Liu, David; Bellaousov, Stanislav; Cox, Anna M.; Martin, Benjamin J. E.; Zhang, Tongwu; Ludwig, Calvin G.; Fabo, Tania; Modhurima, Rodsy; Esgdaille, Dakarai E.; Henriques, Telmo; Brown, Kevin M.; Chanock, Stephen J.; Geyer, Matthias; Adelman, Karen; Sharp, Phillip A.; Young, Richard A.; Boutz, Paul L.; Zon, Leonard I.
作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Howard Hughes Medical Institute; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Howard Hughes Medical Institute; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; St Jude Children's Research Hospital; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); University of Bonn; University of Rochester; Harvard University; Harvard Medical School; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); NIH National Cancer Institute- Division of Cancer Epidemiology & Genetics; Massachusetts Institute of Technology (MIT); Whitehead Institute; University of Rochester; University of Rochester
摘要：RNA surveillance pathways detect and degrade defective transcripts to ensure RNA fidelity. We found that disrupted nuclear RNA surveillance is oncogenic. Cyclin-dependent kinase 13 (CDK13) is mutated in melanoma, and patient-mutated CDK13 accelerates zebrafish melanoma. CDK13 mutation causes aberrant RNA stabilization. CDK13 is required for ZC3H14 phosphorylation, which is necessary and sufficient to promote nuclear RNA degradation. Mutant CDK13 fails to activate nuclear RNA surveillance, caus...
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作者：[Anonymous]
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作者：Pennisi, Elizabeth
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作者：Potter, Tomos; Arendt, Jeff; Bassar, Ronald D.; Watson, Beth; Bentzen, Paul; Travis, Joseph; Reznick, David N.
作者单位：State University System of Florida; Florida State University; University of California System; University of California Riverside; Auburn University System; Auburn University; Dalhousie University
摘要：When females prefer mates with rare phenotypes, sexual selection can maintain rather than deplete genetic variation. However, there is no consensus on why this widespread and frequently observed preference might evolve and persist. We examine the fitness consequences of female preference for rare male color patterns in a natural population of Trinidadian guppies, using a pedigree that spans 10 generations. We demonstrate (i) a rare male reproductive advantage, (ii) that females that mate with ...
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作者：Rockstroem, Johan; Richardson, Katherine
作者单位：Potsdam Institut fur Klimafolgenforschung; University of Copenhagen
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作者：Zhu, Jiangwei; Fu, Li; Guo, Meixia; Wang, Min; Zhao, Yan
作者单位：Nanjing Forestry University; Hangzhou Dianzi University; Henan University; Northeastern University - China
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作者：Brainard, Jeffrey
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作者：De Marco Jr, Paulo; de Souza, Rodrigo A.; Andrade, Andre F. A.; Villen-Perez, Sara; Nobrega, Caroline Correa; Campello, Luiza Motta; Caldas, Marcellus
作者单位：Universidade Federal de Goias; Universidad de Alcala; Universidade de Brasilia; Kansas State University
摘要：Areas set aside for conservation within private lands may be key to enhancing biodiversity-friendly landscapes. This conservation strategy should be especially effective in highly threatened regions that are poorly protected by public lands, such as the Brazilian Cerrado. Brazil's Native Vegetation Protection Law has included set-aside areas within private properties, but their relevance to conservation has not been evaluated. We assess whether private lands are contributing to biodiversity in...
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作者：Poertner, H. -O.; Scholes, R. J.; Arneth, A.; Barnes, D. K. A.; Burrows, M. T.; Diamond, S. E.; Duarte, C. M.; Kiessling, W.; Leadley, P.; Managi, S.; McElwee, P.; Midgley, G.; Ngo, H. T.; Obura, D.; Pascual, U.; Sankaran, M.; Shin, Y. J.; Val, A. L.
作者单位：Helmholtz Association; Alfred Wegener Institute, Helmholtz Centre for Polar & Marine Research; University of Bremen; University of Witwatersrand; Helmholtz Association; Karlsruhe Institute of Technology; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC British Antarctic Survey; University of the Highlands & Islands; University System of Ohio; Case Western Reserve University; King Abdullah University of Science & Technology; King Abdullah University of Science & Technology; University of Erlangen Nuremberg; Centre National de la Recherche Scientifique (CNRS); AgroParisTech; Universite Paris Saclay; Kyushu University; Rutgers University System; Rutgers University New Brunswick; Stellenbosch University; Food & Agriculture Organization of the United Nations (FAO); University of Queensland; Basque Centre for Climate Change (BC3); Basque Foundation for Science; University of Bern; Tata Institute of Fundamental Research (TIFR); National Centre for Biological Sciences (NCBS); Institut de Recherche pour le Developpement (IRD); Ifremer; Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS)
摘要：Earth's biodiversity and human societies face pollution, overconsumption of natural resources, urbanization, demographic shifts, social and economic inequalities, and habitat loss, many of which are exacerbated by climate change. Here, we review links among climate, biodiversity, and society and develop a roadmap toward sustainability. These include limiting warming to 1.5 degrees C and effectively conserving and restoring functional ecosystems on 30 to 50% of land, freshwater, and ocean scape...
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作者：Brainard, Jeffrey
