Science

最新文章

• Irrigation plan threatens key wetland in Spain Andalusia's plan to aid farmers draws fierce criticism from scientists and European Union AI翻译
  作者：Amigo, Ignacio
• A genomic timescale for placental mammal evolution AI翻译
  作者：Foley, Nicole M.; Mason, Victor C.; Harris, Andrew J.; Bredemeyer, Kevin R.; Damas, Joana; Lewin, Harris A.; Eizirik, Eduardo; Gatesy, John; Karlsson, Elinor K.; Lindblad-Toh, Kerstin; Zoonomia Consortium, Zoonomia Consortium; Springer, Mark S.; Murphy, William J.
  作者单位：Texas A&M University System; Texas A&M University College Station; University of Bern; Texas A&M University System; Texas A&M University College Station; University of California System; University of California Davis; University of California System; University of California Davis; Pontificia Universidade Catolica Do Rio Grande Do Sul; American Museum of Natural History (AMNH); University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester; Uppsala University; University of California System; University of California Riverside
  摘要：The precise pattern and timing of speciation events that gave rise to all living placental mammals remain controversial. We provide a comprehensive phylogenetic analysis of genetic variation across an alignment of 241 placental mammal genome assemblies, addressing prior concerns regarding limited genomic sampling across species. We compared neutral genome-wide phylogenomic signals using concatenation and coalescent-based approaches, interrogated phylogenetic variation across chromosomes, and a...
• Integrating gene annotation with orthology inference at scale AI翻译
  作者：Kirilenko, Bogdan M.; Munegowda, Chetan; Osipova, Ekaterina; Jebb, David; Sharma, Virag; Blumer, Moritz; Morales, Ariadna E.; Ahmed, Alexis-Walid; Kontopoulos, Dimitrios-Georgios; Hilgers, Leon; Lindblad-Toh, Kerstin; Karlsson, Elinor K.; Hiller, Michael
  作者单位：Max Planck Society; Max Planck Society; Leibniz Association; Senckenberg Gesellschaft fur Naturforschung (SGN); Goethe University Frankfurt; Uppsala University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Massachusetts System; University of Massachusetts Worcester; UMass Chan Medical School; University of Massachusetts System; University of Massachusetts Worcester; UMass Chan Medical School; University of Limerick
  摘要：Annotating coding genes and inferring orthologs are two classical challenges in genomics and evolutionary biology that have traditionally been approached separately, limiting scalability. We present TOGA (Tool to infer Orthologs from Genome Alignments), a method that integrates structural gene annotation and orthology inference. TOGA implements a different paradigm to infer orthologous loci, improves ortholog detection and annotation of conserved genes compared with state-of-the-art methods, a...
• A 'mind boggling' 19,000 seamounts discovered AI翻译
  作者：Voosen, Paul
• Top-down design of protein architectures with reinforcement learning AI翻译
  作者：Lutz, Isaac D.; Wang, Shunzhi; Norn, Christoffer; Courbet, Alexis; Borst, Andrew J.; Zhao, Yan Ting; Dosey, Annie; Cao, Longxing; Xu, Jinwei; Leaf, Elizabeth M.; Treichel, Catherine; Litvicov, Patrisia; Li, Zhe; Goodson, Alexander D.; Rivera-Sanchez, Paula; Bratovianu, Ana -Maria; Baek, Minkyung; King, Neil P.; Ruohola-Baker, Hannele; Baker, David
  作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Westlake University; Seoul National University (SNU)
  摘要：As a result of evolutionary selection, the subunits of naturally occurring protein assemblies often fit together with substantial shape complementarity to generate architectures optimal for function in a manner not achievable by current design approaches. We describe a top-down reinforcement learning- based design approach that solves this problem using Monte Carlo tree search to sample protein conformers in the context of an overall architecture and specified functional constraints. Cryo-elec...
• Could you spare an acre for conservation? rivate landowners must engage in biodiversity conservation AI翻译
  作者：Machado, Ricardo B.; Aguiar, Ludmilla M. S.
  作者单位：Universidade de Brasilia
• Fixing the desalination membrane pipeline Materials discovery alone has not translated into lower-cost water treatment AI翻译
  作者：McCutcheon, Jeffrey R.; Mauter, Meagan S.
  作者单位：University of Connecticut; Stanford University; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
• Early test for Parkinson's disease AI翻译
  作者：Brainard, Jeffrey
• TRUST BUT VERIFY US labs are overhauling the nuclear stockpile. Can they validate the weapons without bomb tests? AI翻译
  作者：Scoles, Sarah
• Tumor suppression by RNA surveillance A cyclin-dependent kinase triggers degradation of prematurely terminated RNAs AI翻译
  作者：Fisher, Robert P.
  作者单位：Icahn School of Medicine at Mount Sinai