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• Panel urges caution in tying social, behavioral traits to genes Experts split on whether risks of perpetuating racism mean group comparisons should not be done AI翻译
  作者：Kaiser, Jocelyn
• RAD51 bypasses the CMG helicase to promote replication fork reversal AI翻译
  作者：Liu, Wenpeng; Saito, Yuichiro; Jackson, Jessica; Bhowmick, Rahul; Kanemaki, Masato T.; Vindigni, Alessandro; Cortez, David
  作者单位：Vanderbilt University; Research Organization of Information & Systems (ROIS); National Institute of Genetics (NIG) - Japan; Washington University (WUSTL); Graduate University for Advanced Studies - Japan; University of Tokyo; Memorial Sloan Kettering Cancer Center
  摘要：Replication fork reversal safeguards genome integrity as a replication stress response. DNA translocases and the RAD51 recombinase catalyze reversal. However, it remains unknown why RAD51 is required and what happens to the replication machinery during reversal. We find that RAD51 uses its strand exchange activity to circumvent the replicative helicase, which remains bound to the stalled fork. RAD51 is not required for fork reversal if the helicase is unloaded. Thus, we propose that RAD51 crea...
• Minimizing buried interfacial defects for efficient inverted perovskite solar cells AI翻译
  作者：Zhang, Shuo; Ye, Fangyuan; Wang, Xiaoyu; Chen, Rui; Zhang, Huidong; Zhan, Liqing; Jiang, Xianyuan; Li, Yawen; Ji, Xiaoyu; Liu, Shuaijun; Yu, Miaojie; Yu, Furong; Zhang, Yilin; Wu, Ruihan; Liu, Zonghao; Ning, Zhijun; Neher, Dieter; Han, Liyuan; Lin, Yuze; Tian, He; Chen, Wei; Stolterfoht, Martin; Zhang, Lijun; Zhu, Wei-Hong; Wu, Yongzhen
  作者单位：East China University of Science & Technology; East China University of Science & Technology; University of Potsdam; Jilin University; Huazhong University of Science & Technology; ShanghaiTech University; Chinese Academy of Sciences; Institute of Chemistry, CAS; Shanghai Jiao Tong University
  摘要：Controlling the perovskite morphology and defects at the buried perovskite-substrate interface is challenging for inverted perovskite solar cells. In this work, we report an amphiphilic molecular hole transporter, (2-(4-(bis(4-methoxyphenyl)amino)phenyl)-1-cyanovinyl)phosphonic acid, that features a multifunctional cyanovinyl phosphonic acid group and forms a superwetting underlayer for perovskite deposition, which enables high-quality perovskite films with minimized defects at the buried inte...
• Ultrafast reversible self-assembly of living tangled matter AI翻译
  作者：Patil, Vishal P.; Tuazon, Harry; Kaufman, Emily; Chakrabortty, Tuhin; Qin, David; Dunkel, Jorn; Bhamla, M. Saad
  作者单位：Stanford University; University System of Georgia; Georgia Institute of Technology; University System of Georgia; Georgia Institute of Technology; Massachusetts Institute of Technology (MIT)
  摘要：Tangled active filaments are ubiquitous in nature, from chromosomal DNA and cilia carpets to root networks and worm collectives. How activity and elasticity facilitate collective topological transformations in living tangled matter is not well understood. We studied California blackworms (Lumbriculus variegatus), which slowly form tangles in minutes but can untangle in milliseconds. Combining ultrasound imaging, theoretical analysis, and simulations, we developed and validated a mechanistic mo...
• Put your whole self in AI翻译
  作者：Thorp, H. Holden
• Mammalian evolution of human cis-regulatory elements and transcription factor binding sites AI翻译
  作者：Andrews, Gregory; Fan, Kaili; Pratt, Henry E.; Phalke, Nishigandha; Karlsson, Elinor K.; Lindblad-Toh, Kerstin; Gazal, Steven; Moore, Jill E.; Weng, Zhiping
  作者单位：University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester; Uppsala University; University of Southern California; University of Southern California; Harvard University
  摘要：Understanding the regulatory landscape of the human genome is a long-standing objective of modern biology. Using the reference-free alignment across 241 mammalian genomes produced by the Zoonomia Consortium, we charted evolutionary trajectories for 0.92 million human candidate cis-regulatory elements (cCREs) and 15.6 million human transcription factor binding sites (TFBSs). We identified 439,461 cCREs and 2,024,062 TFBSs under evolutionary constraint. Genes near constrained elements perform fu...
• A magnified compact galaxy at redshift 9.51 with strong nebular emission lines AI翻译
  作者：Williams, Hayley; Kelly, Patrick L.; Chen, Wenlei; Brammer, Gabriel; Zitrin, Adi; Treu, Tommaso; Scarlata, Claudia; Koekemoer, Anton M.; Oguri, Masamune; Lin, Yu-Heng; Diego, Jose M.; Nonino, Mario; Hjorth, Jens; Langeroodi, Danial; Broadhurst, Tom; Rogers, Noah; Perez-Fournon, Ismael; Foley, Ryan J.; Jha, Saurabh; Filippenko, Alexei, V; Strolger, Lou; Pierel, Justin; Poidevin, Frederick; Yang, Lilan
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Copenhagen; Niels Bohr Institute; Ben-Gurion University of the Negev; University of California System; University of California Los Angeles; Space Telescope Science Institute; Chiba University; Chiba University; Consejo Superior de Investigaciones Cientificas (CSIC); Universidad de Cantabria; CSIC - Instituto de Fisica de Cantabria (IFCA); Istituto Nazionale Astrofisica (INAF); University of Copenhagen; Niels Bohr Institute; University of Basque Country; Basque Foundation for Science; Instituto de Astrofisica de Canarias; Universidad de la Laguna; University of California System; University of California Santa Cruz; Rutgers University System; Rutgers University New Brunswick; University of California System; University of California Berkeley; University of Tokyo
  摘要：Ultraviolet light from early galaxies is thought to have ionized gas in the intergalactic medium. However, there are few observational constraints on this epoch because of the faintness of those galaxies and the redshift of their optical light into the infrared. We report the observation, in JWST imaging, of a distant galaxy that is magnified by gravitational lensing. JWST spectroscopy of the galaxy, at rest-frame optical wavelengths, detects strong nebular emission lines that are attributable...
• Data hub targets health inequities AI翻译
  作者：[Anonymous]
• Control issues AI翻译
  作者：Bogner, Peter
• Why We Teach Science (and Why We Should) AI翻译
  作者：Wai, Jonathan
  作者单位：University of Arkansas System; University of Arkansas Fayetteville; University of Arkansas System; University of Arkansas Fayetteville