作者：Lyu, Baoqian; Wang, Shuchang; Wyckhuys, Kris A. G.; Liu, Zhuo
作者单位：Chinese Academy of Tropical Agricultural Sciences; University of Queensland
作者：Malik, Nazma; Ferreira, Bibiana I.; Hollstein, Pablo E.; Curtis, Stephanie D.; Trefts, Elijah; Novak, Sammy Weiser; Yu, Jingting; Gilson, Rebecca; Hellberg, Kristina; Fang, Lingjing; Sheridan, Arlo; Hah, Nasun; Shadel, Gerald S.; Manor, Uri; Shaw, Reuben J.
作者单位：Salk Institute; Salk Institute; Salk Institute; Salk Institute
摘要：Cells respond to mitochondrial poisons with rapid activation of the adenosine monophosphate-activated protein kinase (AMPK), causing acute metabolic changes through phosphorylation and prolonged adaptation of metabolism through transcriptional effects. Transcription factor EB (TFEB) is a major effector of AMPK that increases expression of lysosome genes in response to energetic stress, but how AMPK activates TFEB remains unresolved. We demonstrate that AMPK directly phosphorylates five conserv...
作者：Welch, E. Celeste
作者单位：Brown University; Columbia University
作者：Gordin, Michael D.
作者单位：Princeton University
作者：Sun, Bohan; Kang, Sung Hoon
作者单位：Johns Hopkins University; Johns Hopkins University
作者：Dall, Morten; Pedersen, Maria Hauge
作者单位：University of Copenhagen; Novo Nordisk Foundation
作者：Sajjath, Sairaj M.; Gola, Anita; Fuchs, Elaine
作者单位：Rockefeller University; Howard Hughes Medical Institute
