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• Assisted reproductive technologies at the nexus of fertility treatment and disease prevention AI翻译
  作者：Herbert, Mary; Choudhary, Meenakshi; Zander-Fox, Deidre
  作者单位：Newcastle University - UK; Newcastle Upon Tyne Hospitals NHS Foundation Trust; Monash University; Monash IVF; Monash University
  摘要：Assisted reproductive technology (ART) refers to processing gametes in vitro and usually involves in vitro fertilization. Originally developed for the treatment of infertility, culture of human embryos in vitro also provides an opportunity to screen embryos for inherited genetic disorders of the nuclear and mitochondrial genomes. Progress in identifying causative genetic variants has massively increased the scope of preimplantation genetic testing in preventing genetic disorders. However, beca...
• Oldest evidence of abundant C4 grasses and habitat heterogeneity in eastern Africa AI翻译
  作者：Peppe, Daniel J.; Cote, Susanne M.; Deino, Alan L.; Fox, David L.; Kingston, John D.; Kinyanjui, Rahab N.; Lukens, William E.; MacLatchy, Laura M.; Novello, Alice; Stromberg, Caroline A. E.; Driese, Steven G.; Garrett, Nicole D.; Hillis, Kayla R.; Jacobs, Bonnie F.; Jenkins, Kirsten E. H.; Kityo, Robert M.; Lehmann, Thomas; Manthi, Fredrick K.; Mbua, Emma N.; Michel, Lauren A.; Miller, Ellen R.; Mugume, Amon A. T.; Muteti, Samuel N.; Nengo, Isaiah O.; Oginga, Kennedy O.; Phelps, Samuel R.; Polissar, Pratigya; Rossie, James B.; Stevens, Nancy J.; Uno, Kevin T.; McNulty, Kieran P.
  作者单位：Baylor University; University of Calgary; Berkeley Geochronolgy Center; University of Minnesota System; University of Minnesota Twin Cities; University of Michigan System; University of Michigan; Max Planck Society; Smithsonian Institution; Smithsonian National Museum of Natural History; James Madison University; University of Michigan System; University of Michigan; Institut de Recherche pour le Developpement (IRD); Universite PSL; College de France; INRAE; Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); University of Washington; University of Washington Seattle; University of Minnesota System; University of Minnesota Twin Cities; Tennessee Technological University; Southern Methodist University; Makerere University; Leibniz Association; Senckenberg Gesellschaft fur Naturforschung (SGN); Wake Forest University; State University of New York (SUNY) System; Stony Brook University; State University of New York (SUNY) System; Stony Brook University; Harvard University; University of California System; University of California Santa Cruz; University System of Ohio; Ohio University; University System of Ohio; Ohio University; Columbia University; Aix-Marseille Universite
  摘要：The assembly of Africa's iconic C-4 grassland ecosystems is central to evolutionary interpretations of many mammal lineages, including hominins. C-4 grasses are thought to have become ecologically dominant in Africa only after 10 million years ago (Ma). However, paleobotanical records older than 10 Ma are sparse, limiting assessment of the timing and nature of C-4 biomass expansion. This study uses a multiproxy design to document vegetation structure from nine Early Miocene mammal site complex...
• Lab gear has a heavy carbon cost AI翻译
  作者：Brainard, Jeffrey
• Direct imaging and astrometric detection of a gas giant planet orbiting an accelerating star AI翻译
  作者：Currie, Thayne; Brandt, Mirek; Brandt, Timothy D.; Lacy, Brianna; Burrows, Adam; Guyon, Olivier; Tamura, Motohide; Liu, Ranger Y.; Sagynbayeva, Sabina; Tobin, Taylor; Chilcote, Jeffrey; Groff, Tyler; Marois, Christian; Thompson, William; Murphy, Simon J.; Kuzuhara, Masayuki; Lawson, Kellen; Lozi, Julien; Deo, Vincent; Vievard, Sebastien; Skaf, Nour; Uyama, Taichi; Jovanovic, Nemanja; Martinache, Frantz; Kasdin, N. Jeremy; Kudo, Tomoyuki; McElwain, Michael; Janson, Markus; Wisniewski, John; Hodapp, Klaus; Nishikawa, Jun; Helminiak, Krzysztof; Kwon, Jungmi; Hayashi, Masahiko
  作者单位：National Institutes of Natural Sciences (NINS) - Japan; National Astronomical Observatory of Japan (NAOJ); University of Texas System; University of Texas at San Antonio; Eureka Scientific; University of California System; University of California Santa Barbara; Princeton University; University of Texas System; University of Texas Austin; National Institutes of Natural Sciences (NINS) - Japan; Astrobiology Center (ABC); University of Arizona; National Institutes of Natural Sciences (NINS) - Japan; National Astronomical Observatory of Japan (NAOJ); University of Tokyo; Columbia University; State University of New York (SUNY) System; Stony Brook University; University of Notre Dame; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; National Research Council Canada; University of Victoria; University of Sydney; University of Southern Queensland; California Institute of Technology; California Institute of Technology; Universite Cote d'Azur; Observatoire de la Cote d'Azur; Princeton University; Stockholm University; George Mason University; University of Hawaii System; University Hawaii Hilo; Polish Academy of Sciences; Nicolaus Copernicus Astronomical Center of the Polish Academy of Sciences; University of Michigan System; University of Michigan
  摘要：Direct imaging of gas giant exoplanets provides information on their atmospheres and the architectures of planetary systems. However, few planets have been detected in blind surveys with direct imaging. Using astrometry from the Gaia and Hipparcos spacecraft, we identified dynamical evidence for a gas giant planet around the nearby star HIP 99770. We confirmed the detection of this planet with direct imaging using the Subaru Coronagraphic Extreme Adaptive Optics instrument. The planet, HIP 997...
• Barriers to progress in pregnancy research How can we break through AI翻译
  作者：Stock, Sarah J.; Aiken, Catherine E.
  作者单位：University of Edinburgh; University of Edinburgh; University of Cambridge; University of Cambridge; University of Cambridge; Cambridge University Hospitals NHS Foundation Trust; Addenbrooke's Hospital; Cambridge University Hospitals NHS Foundation Trust; Addenbrooke's Hospital; University of Cambridge
  摘要：Healthy pregnancies are fundamental to healthy populations, but very few therapies to improve pregnancy outcomes are available. Fundamental concepts-for example, placentation or the mechanisms that control the onset of labor-remain understudied and incompletely understood. A key issue is that research efforts must capture the complexity of the tripartite maternal-placental-fetal system, the dynamics of which change throughout gestation. Studying pregnancy disorders is complicated by the diffic...
• Mechanical nonreciprocity in a uniform composite material AI翻译
  作者：Wang, Xiang; Li, Zhihao; Wang, Shuxu; Sano, Koki; Sun, Zhifang; Shao, Zhenhua; Takeishi, Asuka; Matsubara, Seishiro; Okumura, Dai; Sakai, Nobuyuki; Sasaki, Takayoshi; Aida, Takuzo; Ishida, Yasuhiro
  作者单位：RIKEN; University of Tokyo; RIKEN; RIKEN; Nagoya University; National Institute for Materials Science; Shinshu University
  摘要：Mechanical nonreciprocity, or the asymmetric transmission of mechanical quantities between two points in space, is crucial for developing systems that can guide, damp, and control mechanical energy. We report a uniform composite hydrogel that displays substantial mechanical nonreciprocity, owing to direction-dependent buckling of embedded nanofillers. This material exhibits an elastic modulus more than 60 times higher when sheared in one direction compared with the opposite direction. Conseque...
• Genentech finds no fraud inquiry AI翻译
  作者：Brainard, Jeffrey
• The origins and functional effects of postzygotic mutations throughout the human life span AI翻译
  作者：Rockweiler, Nicole B.; Ramu, Avinash; Nagirnaja, Liina; Wong, Wing H.; Noordam, Michiel J.; Drubin, Casey W.; Huang, Ni; Miller, Brian; Todres, Ellen Z.; Vigh-Conrad, Katinka A.; Zito, Antonino; Small, Kerrin S.; Ardlie, Kristin G.; Cohen, Barak A.; Conrad, Donald F.
  作者单位：Washington University (WUSTL); Oregon Health & Science University; Oregon National Primate Research Center; Washington University (WUSTL); Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of London; King's College London; Oregon Health & Science University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Stanford University; Stanford University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital
  摘要：Postzygotic mutations (PZMs) begin to accrue in the human genome immediately after fertilization, but how and when PZMs affect development and lifetime health remain unclear. To study the origins and functional consequences of PZMs, we generated a multitissue atlas of PZMs spanning 54 tissue and cell types from 948 donors. Nearly half the variation in mutation burden among tissue samples can be explained by measured technical and biological effects, and 9% can be attributed to donor-specific e...
• US reboots coronavirus research AI翻译
  作者：Brainard, Jeffrey
• Storied accelerator to test chips AI翻译
  作者：Brainard, Jeffrey