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• BIOLOGY An ancient bacterial gene set the stage for human sight AI翻译
  作者：Pennisi, Elizabeth
• MARKING TIME AI翻译
  作者：Price, Michael
• Immobility-associated thromboprotection is conserved across mammalian species from bear to human AI翻译
  作者：Thienel, Manuela; Mueller-Reif, Johannes B.; Zhang, Zhe; Ehreiser, Vincent; Huth, Judith; Shchurovska, Khrystyna; Kilani, Badr; Schweizer, Lisa; Geyer, Philipp E.; Zwiebel, Maximilian; Novotny, Julia; Luesebrink, Enzo; Little, Gemma; Orban, Martin; Nicolai, Leo; El Nemr, Shaza; Titova, Anna; Spannagl, Michael; Kindberg, Jonas; Evans, Alina L.; Mach, Orpheus; Vogel, Matthias; Tiedt, Steffen; Ormanns, Steffen; Kessler, Barbara; Dueck, Anne; Friebe, Andrea; Jorgensen, Peter Godsk; Majzoub-Altweck, Monir; Blutke, Andreas; Polzin, Amin; Stark, Konstantin; Kaab, Stefan; Maier, Doris; Gibbins, Jonathan M.; Limper, Ulrich; Frobert, Ole; Mann, Matthias; Massberg, Steffen; Petzold, Tobias
  作者单位：University of Munich; Munich Heart Alliance; German Centre for Cardiovascular Research; Max Planck Society; University of Reading; University of Munich; Norwegian Institute Nature Research; Inland Norway University of Applied Sciences; University of Munich; University of Munich; University of Munich; Technical University of Munich; University of Munich; Helmholtz Association; German Aerospace Centre (DLR); Witten Herdecke University; Orebro University; Aarhus University; Aarhus University; Aarhus University
  摘要：Venous thromboembolism (VTE) comprising deep venous thrombosis and pulmonary embolism is a major cause of morbidity and mortality. Short-term immobility-related conditions are a major risk factor for the development of VTE. Paradoxically, long-term immobilized free-ranging hibernating brown bears and paralyzed spinal cord injury (SCI) patients are protected from VTE. We aimed to identify mechanisms of immobility-associated VTE protection in a cross-species approach. Mass spectrometry-based pro...
• Satellites will offer details of air pollution AI翻译
  作者：Brainard, Jeffrey
• Sand through the hourglass AI翻译
  作者：Campana, Jorge Cortez
  作者单位：Pontificia Universidad Catolica de Chile; Universidad de La Serena
• Engineered skin bacteria induce antitumor T cell responses against melanoma AI翻译
  作者：Chen, Y. Erin; Bousbaine, Djenet; Veinbachs, Alessandra; Atabakhsh, Katayoon; Dimas, Alex; Yu, Victor K.; Zhao, Aishan; Enright, Nora J.; Nagashima, Kazuki; Belkaid, Yasmine; Fischbach, Michael A.
  作者单位：Stanford University; Stanford University; Stanford University; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Chan Zuckerberg Initiative (CZI)
  摘要：Certain bacterial colonists induce a highly specific T cell response. A hallmark of this encounter is that adaptive immunity develops preemptively, in the absence of an infection. However, the functional properties of colonist-induced T cells are not well defined, limiting our ability to understand anticommensal immunity and harness it therapeutically. We addressed both challenges by engineering the skin bacterium Staphylococcus epidermidis to express tumor antigens anchored to secreted or cel...
• China blocks key databases AI翻译
  作者：Brainard, Jeffrey
• Hydro authority to return remains AI翻译
  作者：Brainard, Jeffrey
• A global transition to flash droughts under climate change AI翻译
  作者：Yuan, Xing; Wang, Yumiao; Ji, Peng; Wu, Peili; Sheffield, Justin; Otkin, Jason A.
  作者单位：Nanjing University of Information Science & Technology; Nanjing University of Information Science & Technology; Met Office - UK; Hadley Centre; University of Southampton; University of Wisconsin System; University of Wisconsin Madison
  摘要：Flash droughts have occurred frequently worldwide, with a rapid onset that challenges drought monitoring and forecasting capabilities. However, there is no consensus on whether flash droughts have become the new normal because slow droughts may also increase. In this study, we show that drought intensification rates have sped up over subseasonal time scales and that there has been a transition toward more flash droughts over 74% of the global regions identified by the Intergovernmental Panel o...
• A brief history and future prospects of contraception AI翻译
  作者：Anderson, Deborah J.; Johnston, Daniel S.
  作者单位：Boston University; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD); National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD); National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
  摘要：Modern contraception ushered in an era of improved family planning, but more than 60 years after approval of the pill, product gaps and unmet needs still exist. Nearly 250 million women worldwide who want to delay or avoid pregnancy do so ineffectively or not at all, and the principal mechanism of male contraception, condoms, has not changed in 100 years. As a result, about half of the pregnancies that occur globally each year are unintended. Increasing contraceptive options and uptake will cu...