Science

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• Behavior drives morphological change during human evolution AI翻译
  作者：Fannin, Luke D.; Seyoum, Chalachew M.; Venkataraman, Vivek V.; Yeakel, Justin D.; Janis, Christine M.; Cerling, Thure E.; Dominy, Nathaniel J.
  作者单位：Dartmouth College; Dartmouth College; University of Arizona; University of Calgary; University of California System; University of California Merced; The Santa Fe Institute; Brown University; University of Bristol; Utah System of Higher Education; University of Utah; Dartmouth College
  摘要：Dietary shifts and corresponding morphological changes can sometimes evolve in succession, not concurrently-an evolutionary process called behavioral drive. Detecting behavioral drive in the fossil record is challenging because it is difficult to measure behaviors independently from corresponding morphologies. To solve this problem, we focused on a puzzling behavior in the fossil record of some primates: eating graminoid plants. We report carbon and oxygen isotope ratios from fossil cercopithe...
• New scheme for overhead payments faces doubts AI翻译
  作者：Mervis, Jeffrey
• Little-to-no industrial fishing occurs in fully and highly protected marine areas AI翻译
  作者：Raynor, Jennifer; Orofino, Sara; Costello, Christopher; McDonald, Gavin; Mayorga, Juan; Sala, Enric
  作者单位：University of Wisconsin System; University of Wisconsin Madison; University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara; National Geographic Society
  摘要：There is a widespread perception that illegal fishing is common in marine protected areas (MPAs) due to strong incentives for poaching and the high cost of monitoring and enforcement. Using artificial intelligence and satellite-based Earth observations, we provide estimates of industrial fishing activity in fully and highly protected MPAs worldwide, in which such fishing is banned. We find little to no activity in most cases. On average, these MPAs had just one fishing vessel present per 20,00...
• A human homolog of SIR2 antiphage proteins mediates immunity via the Toll-like receptor pathway AI翻译
  作者：Bonhomme, Delphine; Vaysset, Hugo; Ednacot, Eirene Marie Q.; Rodrigues, Vasco; Salloum, Yazan; Cury, Jean; Wang, Anny; Benchetrit, Axel; Affaticati, Pierre; Trejo, Veronica Hernandez; Vittot, Paul; Bories, Charlie; Cornec, Alexis; Levraud, Jean-Pierre; Hernandez, Pedro P.; Benaroch, Philippe; Morehouse, Benjamin R.; Bernheim, Aude; Poirier, Enzo Z.
  作者单位：Universite PSL; UNICANCER; Institut Curie; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Universite Paris Saclay; AgroParisTech; University of California System; University of California Irvine; University of California System; University of California Irvine; Universite PSL; UNICANCER; Institut Curie; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite PSL; UNICANCER; Institut Curie; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); CNRS - National Institute for Biology (INSB); Centre National de la Recherche Scientifique (CNRS); Universite Paris Saclay; Universite Paris Cite; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); University of California System; University of California Irvine; University of California System; University of California Irvine
  摘要：Key actors of mammalian immunity originated from bacterial antiphage systems. The full extent of immune system conservation between bacteria and eukaryotes is unknown. Here, we show that the silent information regulator 2 (SIR2) protein domain, present in antiphage systems, plays a role in eukaryotic innate immunity. We identified SIRal, a human protein with a SIRim domain (subtype of SIR2) that plays a pivotal role in the animal Toll-like receptor pathway of innate immunity and protects again...
• Expansion in situ genome sequencing links nuclear abnormalities to aberrant chromatin regulation AI翻译
  作者：Labade, Ajay S.; Chiang, Zachary D.; Comenho, Caroline; Reginato, Paul L.; Payne, Andrew C.; Earl, Andrew S.; Shrestha, Rojesh; Duarte, Fabiana M.; Habibi, Ehsan; Zhang, Ruochi; Church, George M.; Boyden, Edward S.; Chen, Fei; Buenrostro, Jason D.
  作者单位：Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Howard Hughes Medical Institute; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
  摘要：Microscopy and genomics are used to characterize cell function, but approaches to connect the two types of information are lacking, particularly at subnuclear resolution. Here, we describe expansion in situ genome sequencing (ExIGS), a technology that enables sequencing of genomic DNA and super-resolution localization of nuclear proteins in single cells. Applying ExIGS to progeria-derived fibroblasts revealed that lamin abnormalities are linked to hotspots of aberrant chromatin regulation that...
• A catch in ocean conservation AI翻译
  作者：Worm, Boris
  作者单位：Dalhousie University
• In Other Journals AI翻译
  作者：Vignieri, Sacha; Ross, Sarah H.; Jiang, Di; Lavine, Marc S.; Suleymanov, Yury; Hurtley, Stella M.; Smith, Keith T.
• Reinstate the National Climate Assessment AI翻译
  作者：Landry, Craig E.; Lewis, Lynne; Mcdermott, Shana; Vander Naald, Brian; Smith, Martin D.; Whitehead, John C.
  作者单位：University System of Georgia; University of Georgia; Colorado State University System; Colorado State University Fort Collins; University of Missouri System; University of Missouri Columbia; Drake University; Duke University; University of North Carolina; Appalachian State University
• The secret brilliance of birds AI翻译
  作者：Funk, Michael; Naeem, Shahid
• Eighty years at the nuclear brink AI翻译
  作者：Moniz, Ernest J.
  作者单位：Massachusetts Institute of Technology (MIT)