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作者:Brainard, Jeffrey
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作者:Muir, J.; Anguiano, M.; Kim, C. K.
作者单位:University of California System; University of California Davis; University of California System; University of California Davis
摘要:To determine how neuronal circuits encode and drive behavior, it is often necessary to measure and manipulate different aspects of neurochemical signaling in awake animals. Optogenetics and calcium sensors have paved the way for these types of studies, allowing for the perturbation and readout of spiking activity within genetically defined cell types. However, these methods lack the ability to further disentangle the roles of individual neuromodulator and neuropeptides on circuits and behavior...
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作者:Thorp, H. Holden; Vinson, Valda
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作者:Brainard, Jeffrey
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作者:Brainard, Jeffrey
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作者:Brainard, Jeffrey
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作者:Sepich-Poore, G. D.
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作者:Dijksterhuis, D. E.; Self, M. W.; Possel, J. K.; Peters, J. C.; van Straaten, E. C. W.; Idema, S.; Baaijen, J. C.; van der Salm, S. M. A.; Aarnoutse, E. J.; van Klink, N. C. E.; van Eijsden, P.; Hanslmayr, S.; Chelvarajah, R.; Roux, F.; Kolibius, L. D.; Sawlani, V.; Rollings, D. T.; Dehaene, S.; Roelfsema, P. R.
作者单位:Royal Netherlands Academy of Arts & Sciences; Netherlands Institute for Neuroscience (NIN-KNAW); Maastricht University; Maastricht University; Eindhoven University of Technology; Utrecht University; Utrecht University Medical Center; University of Glasgow; University of Birmingham; University of Birmingham; Columbia University; Universite Paris Saclay; CEA; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite PSL; College de France; Vrije Universiteit Amsterdam; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Institut National de la Sante et de la Recherche Medicale (Inserm)
摘要:During discourse comprehension, every new word adds to an evolving representation of meaning that accumulates over consecutive sentences and constrains the next words. To minimize repetition and utterance length, languages use pronouns, like the word she, to refer to nouns and phrases that were previously introduced. It has been suggested that language comprehension requires that pronouns activate the same neuronal representations as the nouns themselves. We recorded from individual neurons in...
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作者:Gold, Adam C.
作者单位:Environmental Defense Fund
摘要:In 2023, the US Supreme Court's majority ruled in Sackett v. Environmental Protection Agency that only wetlands that are indistinguishable from federally protected waters due to a continuous surface connection are federally protected. This study estimates the potential impact of interpretations of the ruling on federal wetlands protections, using a qualitative measure of wetland wetness as a proxy for the new requirement. An estimated area ranging from similar to 17 million acres (19%) to near...
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作者:Lu, Qiuhe; Hitch, Thomas C. A.; Zhou, Julie Y.; Dwidar, Mohammed; Sangwan, Naseer; Lawrence, Dylan; Nolan, Lila S.; Espenschied, Scott T.; Newhall, Kevin P.; Han, Yi; Karell, Paul E.; Salazar, Vanessa; Baldridge, Megan T.; Clavel, Thomas; Stappenbeck, Thaddeus S.
作者单位:Cleveland Clinic Foundation; RWTH Aachen University; RWTH Aachen University Hospital; Cleveland Clinic Foundation; Cleveland Clinic Foundation; Washington University (WUSTL)
摘要:Harnessing the microbiome to benefit human health requires an initial step in determining the identity and function of causative microorganisms that affect specific host physiological functions. We show a functional screen of the bacterial microbiota from mice with low intestinal immunoglobulin A (IgA) levels; we identified a Gram-negative bacterium, proposed as Tomasiella immunophila, that induces and degrades IgA in the mouse intestine. Mice harboring T. immunophila are susceptible to infect...