作者:Kathe, Claudia
作者单位:University of Lausanne
摘要:Walking is seemingly effortless for most of us. We walk, run, and climb stairs without consciously thinking about each step. However, these simple movements require a highly complex interplay of muscle activations that consists of left-right leg alternation, coordinated muscle co-contractions, and inhibition of antagonistic muscle contractions. Even more fascinating is that stepping can be generated without any communication between the brain and the spinal cord. This property was demonstrated...
作者:Peng, Qiupeng; Hwang, Meemie U.; Renteria-Gomez, Angel; Mukherjee, Poulami; Young, Ryan M.; Qiu, Yunfan; Wasielewski, Michael R.; Gutierrez, Osvaldo; Scheidt, Karl A.
作者单位:Northwestern University; Texas A&M University System; Texas A&M University College Station; Northwestern University
摘要:The excitation of carbonyl compounds by light to generate radical intermediates has historically been restricted to ketones and aldehydes; carboxylic acids have been overlooked because of high energy requirements and low quantum efficiency. A successful activation strategy would necessitate a bathochromic shift in the absorbance profile, an increase in triplet diradical lifetime, and ease of further functionalization. We present a single-flask transformation of carboxylic acids to acyl phospho...
作者:Cater, Rosemary J.
作者单位:University of Queensland
摘要:The brain is our most important and sophisticated organ. To develop this organ-all the way from an embryo to an adult brain, with its hundreds of billions of neurons and glial cells and 400 miles of vasculature-is no small task. Each mammalian cell contains more than one billion phospholipids. More than half of these lipids are phosphatidylcholine. The sheer density of cells in the brain endows it with an immense hunger for this critical cellular component. In 1956, Eugene P. Kennedy discovere...
作者:Hao, Shijie; Zhu, Xiaojia; Huang, Zhi; Yang, Qianqian; Liu, Hean; Wu, Yan; Zhan, Yafeng; Dong, Yu; Li, Chao; Wang, He; Haasdijk, Elize; Wu, Zihan; Li, Shenglong; Yan, Haotian; Zhu, Lijing; Guo, Shiyong; Wang, Zefang; Ye, Aojun; Lin, Youning; Cui, Luman; Tan, Xing; Liu, Huanlin; Wang, Mingli; Chen, Jing; Zhong, Yanqing; Du, Wensi; Wang, Guangling; Lai, Tingting; Cao, Mengdi; Yang, Tao; Xu, Yuanfang; Li, Ling; Yu, Qian; Zhuang, Zhenkun; Xia, Ying; Lei, Ying; An, Yingjie; Cheng, Mengnan; Zhao, Yun; Han, Lei; Yuan, Yue; Song, Xinxiang; Song, Yumo; Gu, Liqin; Liu, Chang; Lin, Xiumei; Wang, Ruiqi; Wang, Zhifeng; Wang, Yang; Li, Shenyu; Li, Huanhuan; Song, Jingjing; Chen, Mengni; Zhou, Wanqiu; Yuan, Nini; Sun, Suhong; Wang, Shiwen; Chen, Yu; Zheng, Mingyuan; Fang, Jiao; Zhang, Ruiyi; Zhang, Shuzhen; Chai, Qinwen; Liu, Jiabing; Wei, Wu; He, Jie; Zhou, Haibo; Sun, Yangang; Liu, Zhen; Liu, Chuanyu; Yao, Jianhua; Liang, Zhifeng; Xu, Xun; Poo, Muming; Li, Chengyu; De Zeeuw, Chris I.; Shen, Zhiming; Liu, Zhiyong; Liu, Longqi; Liu, Shiping; Sun, Yidi; Liu, Cirong
作者单位:Chinese Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Beijing Genomics Institute (BGI); South China University of Technology; Lingang Laboratory; Erasmus University Rotterdam; Erasmus MC; Royal Netherlands Academy of Arts & Sciences; Netherlands Institute for Neuroscience (NIN-KNAW); Tencent; Beijing Genomics Institute (BGI); Shanxi Medical University; Shanghai Center for Brain Science & Brain-Inspired Technology
摘要:The molecular and cellular organization of the primate cerebellum remains poorly characterized. We obtained single-cell spatial transcriptomic atlases of macaque, marmoset, and mouse cerebella and identified primate-specific cell subtypes, including Purkinje cells and molecular-layer interneurons, that show different expression of the glutamate ionotropic receptor Delta type subunit 2 (GRID2) gene. Distinct gene expression profiles were found in anterior, posterior, and vestibular regions in a...
作者:Omifolaji, James Kehinde; Adedoyin, Sunday Opeyemi; Khan, Tauheed Ullah
作者单位:Guangdong Academy of Sciences; Institute of Zoology, Guangdong Academy of Sciences