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作者：Ferdowsi, Ahmad; Zolghadr-Asli, Babak; Aghakouchak, Amir
作者单位：Semnan University; University of Queensland; University of Exeter; University of California System; University of California Irvine
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作者：Boon, Sarah
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作者：Chen, Xi Dawn; Chen, Zeyu; Wythes, George; Zhang, Yifan; Orr, Benno C.; Sun, Gary; Chao, Yu-Kai; Navarro Torres, Andrea; Thao, Ka; Vallurupalli, Mounica; Sun, Jing; Borji, Mehdi; Tkacik, Emre; Chen, Haiqi; Bernstein, Bradley E.; Chen, Fei
作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
摘要：Deciphering the context-specific relationship between sequence and function is a major challenge in genomics. Existing tools for inducing locus-specific hypermutation and evolution in the native genome context are limited. Here we present a programmable platform for long-range, locus-specific hypermutation called helicase-assisted continuous editing (HACE). HACE leverages CRISPR-Cas9 to target a processive helicase-deaminase fusion that incurs mutations across large (>1000-base pair) genomic i...
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作者：Kang, Tae Gun; Lan, Xin; Mi, Tian; Chen, Hongfeng; Alli, Shanta; Lim, Song-Eun; Bhatara, Sheetal; Vasandan, Anoop Babu; Ward, Grace; Bentivegna, Sofia; Jang, Josh; Spatz, Marianne L.; Han, Jin-Hwan; Schlotmann, Balthasar Clemens; Jespersen, Jakob Schmidt; Derenzo, Christopher; Vogel, Peter; Yu, Jiyang; Baylin, Stephen; Jones, Peter; O'Connell, Casey; Gronbaek, Kirsten; Youngblood, Ben; Zebley, Caitlin C.
作者单位：St Jude Children's Research Hospital; University of Tennessee System; University of Tennessee Health Science Center; St Jude Children's Research Hospital; University of Copenhagen; Copenhagen University Hospital; Rigshospitalet; University of Copenhagen; Van Andel Institute; Merck & Company; Merck & Company USA; Rigshospitalet; University of Copenhagen; Copenhagen University Hospital; St Jude Children's Research Hospital; St Jude Children's Research Hospital; Johns Hopkins University; Johns Hopkins Medicine; University of Southern California; University of Copenhagen
摘要：Epigenetic reinforcement of T cell exhaustion is known to be a major barrier limiting T cell responses during immunotherapy. However, the core epigenetic regulators restricting antitumor immunity during prolonged antigen exposure are not clear. We investigated three commonly mutated epigenetic regulators that promote clonal hematopoiesis to determine whether they affect T cell stemness and response to checkpoint blockade immunotherapy. CD8 T cells lacking Dnmt3a, Tet2, or Asxl1 preserved a pro...
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作者：Maury, Eduardo A.; Jones, Attila; Seplyarskiy, Vladimir; Nguyen, Thanh Thanh L.; Rosenbluh, Chaggai; Bae, Taejong; Wang, Yifan; Abyzov, Alexej; Khoshkhoo, Sattar; Chahine, Yasmine; Zhao, Sijing; Venkatesh, Sanan; Root, Elise; Voloudakis, Georgios; Roussos, Panagiotis; Park, Peter J.; Akbarian, Schahram; Brennand, Kristen; Reilly, Steven; Lee, Eunjung A.; Sunyaev, Shamil R.; Walsh, Christopher A.; Chess, Andrew
作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School; Yale University; Yale University; Mayo Clinic; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Harvard University; Harvard Medical School; Howard Hughes Medical Institute; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital
摘要：Germline mutations modulate the risk of developing schizophrenia (SCZ). Much less is known about the role of mosaic somatic mutations in the context of SCZ. Deep (239x) whole-genome sequencing (WGS) of brain neurons from 61 SCZ cases and 25 controls postmortem identified mutations occurring during prenatal neurogenesis. SCZ cases showed increased somatic variants in open chromatin, with increased mosaic CpG transversions (CpG>GpG) and T>G mutations at transcription factor binding sites (TFBSs)...
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作者：Harris, Theresa; Alexander, Rashada
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作者：Cho, Adrian
摘要：Models based in statistical physics led to today's neural networks that power chatbots and self-driving cars
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作者：Cyphert, Erika
作者单位：University of California System; University of California San Diego
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作者：Gao, Danpeng; Li, Bo; Liu, Qi; Zhang, Chunlei; Yu, Zexin; Li, Shuai; Gong, Jianqiu; Qian, Liangchen; Vanin, Francesco; Schutt, Kelly; Davis, Melissa A.; Palmstrom, Axel F.; Harvey, Steven P.; Long, Nicholas J.; Luther, Joseph M.; Zeng, Xiao Cheng; Zhu, Zonglong
作者单位：City University of Hong Kong; City University of Hong Kong; Imperial College London; United States Department of Energy (DOE); National Renewable Energy Laboratory - USA; City University of Hong Kong
摘要：Robust contact schemes that boost stability and simplify the production process are needed for perovskite solar cells (PSCs). We codeposited perovskite and hole-selective contact while protecting the perovskite to enable deposition of SnOx/Ag without the use of a fullerene. The SnOx, prepared through atomic layer deposition, serves as a durable inorganic electron transport layer. Tailoring the oxygen vacancy defects in the SnOx layer led to power conversion efficiencies (PCEs) of >25%. Our dev...
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作者：Cael, B. B.; Guidi, Lionel
作者单位：NERC National Oceanography Centre; Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS)
