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作者：Tardelli, Serena; Nizzoli, Leonardo; Tesconi, Maurizio; Conti, Mauro; Nakov, Preslav; Martino, Giovanni Da San; Cresci, Stefano
作者单位：Consiglio Nazionale delle Ricerche (CNR); University of Padua; Mohamed bin Zayed University of Artificial Intelligence MBZUAI
摘要：Large-scale online campaigns, malicious or otherwise, require a significant degree of coordination among participants, which sparked interest in the study of coordinated online behavior . State-of-the-art methods for detecting coordinated behavior perform static analyses, disregarding the temporal dynamics of coordination. Here, we carry out a dynamic analysis of coordinated behavior. To reach our goal, we build a multiplex temporal network and we perform dynamic community detection to identif...
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作者：Janowski, Jordan; Pham, Van A. B.; Vecchioni, Simon; Woloszyn, Karol; Lu, Brandon; Zou, Yijia; Erkalo, Betel; Perren, Lara; Rueb, Joe; Madnick, Jesse; Mao, Chengde; Saito, Masahico; Ohayon, Yoel P.; Jonoska, Natasa; Sha, Ruojie
作者单位：New York University; State University System of Florida; University of South Florida; University of Oregon; Purdue University System; Purdue University
摘要：Tertiary chirality describes the handedness of supramolecular assemblies and relies not only on the primary and secondary structures of the building blocks but also on topological driving forces that have been sparsely characterized. Helical biopolymers, especially DNA, have been extensively investigated as they possess intrinsic chirality that determines the optical, mechanical, and physical properties of the ensuing material. Here, we employ the DNA tensegrity triangle as a model system to l...
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作者：Lee, Soah; Roestd, Alison S. Vander; Blair, Cheavar A.; Kaoh, Kerry; Bremner, Samantha B.; Childers, Matthew C.; Pathak, Divya; Heinrich, Paul; Lee, Daniel; Chirikian, Orlando; Mohran, Saffie E.; Roberts, Brock; Smith, Jacqueline E.; Jahng, James W.; Paik, David T.; Wu, Joseph C.; Gunawardane, Ruwanthi N.; Ruppel, Kathleen M.; Mack, David L.; Pruitt, Beth L.; Regnier, Michael; Wu, Sean M.; Spudich, James A.; Bernstein, Daniel
作者单位：Stanford University; Sungkyunkwan University (SKKU); Sungkyunkwan University (SKKU); Stanford University; University of Michigan System; University of Michigan; University of California System; University of California Santa Barbara; University of Kentucky; University of Washington; University of Washington Seattle; Stanford University; Stanford University
摘要：Determining the pathogenicity of hypertrophic cardiomyopathy-associated mutations in the (3- myosin heavy chain (MYH7) can be challenging due to its variable penetrance and clinical severity. This study investigates the early pathogenic effects of the incomplete- penetrant MYH7 G256E mutation on myosin function that may trigger pathogenic adaptations and hypertrophy. We hypothesized that the G256E mutation would alter myosin biomechanical function, leading to changes in cellular functions. We ...
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作者：Lisovski, Simeon; Hoye, Bethany J.; Conklin, Jesse R.; Battley, Phil F.; Fuller, Richard A.; Gosbell, Ken B.; Klaassen, Marcel; Lee, Chengfa Benjamin; Murray, Nicholas J.; Bauer, Silke
作者单位：Helmholtz Association; Alfred Wegener Institute, Helmholtz Centre for Polar & Marine Research; University of Wollongong; University of Groningen; Massey University; University of Queensland; Deakin University; Helmholtz Association; German Aerospace Centre (DLR); University of Wurzburg; James Cook University; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research; Swiss Ornithological Institute; University of Amsterdam; Swiss Federal Institutes of Technology Domain; ETH Zurich
摘要：The pace and scale of environmental change represent major challenges to many organisms. Animals that move long distances, such as migratory birds, are especially vulnerable to change since they need chains of intact habitat along their migratory routes. Estimating the resilience of such species to environmental changes assists in targeting conservation efforts. We developed a migration modeling framework to predict past (1960s), present (2010s), and future (2060s) optimal migration strategies...
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作者：Yuk, Jisoo; Pandey, Anupam; Park, Leena; Bemis, William E.; Jung, Sunghwan
作者单位：Cornell University; Syracuse University; University of California System; University of California Davis; Cornell University
摘要：Certain fox species plunge -dive into snow to catch prey (e.g., rodents), a hunting mechanism called mousing. Red and arctic foxes can dive into snow at speeds ranging between 2 and 4 m/s. Such mousing behavior is facilitated by a slim, narrow facial structure. Here, we investigate how foxes dive into snow efficiently by studying the role of skull morphology on impact forces it experiences. In this study, we reproduce the mousing behavior in the lab using three-dimensional (3D) printed fox sku...
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作者：Liu, Yidan; Liu, Xiuxing; Chen, Xuhao; Yang, Zhenlan; Chen, Jianqi; Zhu, Weining; Li, Yangyang; Wen, Yuwen; Deng, Caibin; Gu, Chenyang; Lv, Jianjie; Ju, Rong; Zhuo, Yehong; Su, Wenru
作者单位：Sun Yat Sen University; Sun Yat Sen University
摘要：Increased cellular senescence burden contributes in part to age- related organ dysfunction and pathologies. In our study, using mouse models of natural aging, we observed structural and functional decline in the aged retina, which was accompanied by the accumulation of senescent cells and senescence- associated secretory phenotype factors. We further validated the senolytic and senomorphic properties of procyanidin C1 (PCC1) both in vitro and in vivo, the long- term treatment of which ameliora...
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作者：Wang, Teng; Weiss, Andrea; You, Lingchong
作者单位：Duke University; Duke University; Duke University
摘要：The gene content in a metagenomic pool defines the function potential of a microbial community. Natural selection, operating on the level of genomes or genes, shapes the evolution of community functions by enriching some genes while depriving the others. Despite the importance of microbiomes in the environment and health, a general metric to evaluate the communitywide fitness of microbial genes remains lacking. In this work, we adapt the classic neutral model of species and use it to predict h...
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作者：Michaeli, Tal Falick; Sabag, Ofra; Azria, Batia; Fok, Rimma; Abudi, Nathalie; Abramovitch, Rinat; Monin, Jonathan; Gielchinsky, Yuval; Cedar, Howard; Bergman, Yehudit
作者单位：Hebrew University of Jerusalem; Hadassah University Medical Center; Hebrew University of Jerusalem; Hadassah University Medical Center; Hebrew University of Jerusalem; Hadassah University Medical Center; Hebrew University of Jerusalem; Hadassah University Medical Center; Hebrew University of Jerusalem; Hebrew University of Jerusalem; Hadassah University Medical Center; Tel Aviv University; Rabin Medical Center
摘要：As a result of partial hepatectomy, the remaining liver tissue undergoes a process of renewed proliferation that leads to rapid regeneration of the liver. By following the early stages of this process, we observed dramatic programmed changes in the DNA methylation profile, characterized by both de novo and demethylation events, with a subsequent return to the original adult pattern as the liver matures. Strikingly, these transient alterations partially mimic the DNA methylation state of embryo...
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作者：Qu, Wei; Tang, Zhuoyun; Tang, Su; Zhong, Tao; Zhao, Huinan; Tian, Shuanghong; Shu, Dong; He, Chun
作者单位：Sun Yat Sen University; South China Normal University
摘要：The advancement of atomically precise dinuclear heterogeneous catalysts holds great potential in achieving efficient catalytic ozonation performance and contributes to the understanding of synergy mechanisms during reaction conditions. Herein, we demonstrate a ship - in - a- bottle and pyrolysis strategy that utilizes Fe2(CO)9 dinuclear- cluster to precisely construct Fe2 site, consisting of two Fe1-N3 units connected by Fe - Fe bonds and firmly bonded to N - doped carbon. Systematic character...
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作者：van Brussel, Leonard D.; Boksem, Maarten A. S.; Dietvorst, Roeland C.; Smidts, Ale
作者单位：Erasmus University Rotterdam; Erasmus University Rotterdam - Excl Erasmus MC
摘要：A major aspiration of investors is to better forecast stock performance. Interestingly, emerging neuroforecasting research suggests that brain activity associated with anticipatory reward relates to market behavior and population - wide preferences, including stock price dynamics. In this study, we extend these findings to professional investors processing comprehensive real - world information on stock investment options while making predictions of long - term stock performance. Using functio...
