Proceedings of the National Academy of Sciences of the United States of America

最新文章

• ATAD5 functions as a regulatory platform for Ub-PCNA deubiquitination AI翻译
  作者：Ryu, Eunjin; Yoo, Juyeong; Kang, Mi-Sun; Ha, Na Young; Jang, Yewon; Kim, Jinwoo; Kim, Yeongjae; Kim, Byung-Gyu; Kim, Shinseog; Myung, Kyungjae; Kang, Sukhyun
  作者单位：Institute for Basic Science - Korea (IBS); Ulsan National Institute of Science & Technology (UNIST); Ulsan National Institute of Science & Technology (UNIST); Harvard University; Harvard Medical School
  摘要：Ubiquitination status of proliferating cell nuclear antigen (PCNA) is crucial for regulating DNA lesion bypass. After the resolution of fork stalling, PCNA is subsequently deubiquitinated, but the underlying mechanism remains undefined. We found that the DNA- loaded Ub-PCNA through distinct DNA- binding and PCNA- binding motifs. facilitating the deubiquitination of DNA- loaded Ub-PCNA. ATAD5 also enhances the Ub-PCNA deubiquitination by USP7 and USP11 through specific interactions. had increas...
• m6A modification plays an integral role in mRNA stability and translation during pattern- triggered immunity AI翻译
  作者：Chen, Tianyuan; Greene, George H.; Motley, Jonathan; Mwimba, Musoki; Luo, Guan - Zheng; Xu, Guoyong; Karapetyan, Sargis; Xiang, Yezi; Liu, Chang; He, Chuan; Dong, Xinnian
  作者单位：Howard Hughes Medical Institute; Duke University; Duke University; Howard Hughes Medical Institute; University of Chicago; University of Chicago; Wuhan University
  摘要：Plants employ distinct mechanisms to respond to environmental changes. Modification mRNA by N 6- methyladenosine (m6A), known to affect the fate of mRNA, maybe one such mechanism to reprogram mRNA processing and translatability upon stress. However, is difficult to distinguish a direct role from a pleiotropic effect for this modification due its prevalence in RNA. Through characterization of the transient knockdown- mutants m6A writer components and mutants of specific m6A readers,we demonstra...
• The yielding of granular matter is marginally stable and critical AI翻译
  作者：Shang, Jin; Wang, Yinqiao; Pan, Deng; Jin, Yuliang; Zhang, Jie
  作者单位：Shanghai Jiao Tong University; University of Tokyo; Chinese Academy of Sciences; Institute of Theoretical Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Shanghai Jiao Tong University
  摘要：Amorphous materials undergo a transition from liquid-like to solid-like states through processes like rapid quenching or densification. Under external loads, they exhibit yielding, with minimal structural changes compared to crystals. However, these universal characteristics are rarely explored comprehensively in a single granular experiment due to the added complexity of inherent friction. The discernible differences between static configurations before and after yielding are largely unaddres...
• Laws of macroevolutionary expansion AI翻译
  作者：Zliobaite, Indre
  作者单位：University of Helsinki; University of Helsinki
  摘要：Van Valen's law of constant extinction postulates that in comparable ecological contexts, the probability for a taxon to survive to the next time interval is independent of how long it has already existed. The law implies that species do not age, that is, the survival probability from one time step to the next does not decrease with species' age. While the original law describes survivorship over time, here we show that there is a counterpart to the law describing species dynamics in space. In...
• Zfp106 binds to G- quadruplex RNAs and inhibits RAN translation and formation of RNA foci caused by G4C2 repeats AI翻译
  作者：Celona, Barbara; Salomonsson, Sally E.; Wu, Haifan; Dang, Bobo; Kratochvil, Huong T.; Clelland, Claire D.; DeGrado, William F.; Black, Brian L.
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Wichita State University; Westlake University; Westlake University; University of North Carolina; University of North Carolina Chapel Hill
  摘要：Expansion of intronic GGGGCC repeats in the C9orf72 gene causes amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Transcription of the expanded repeats results in the formation of RNA- containing nuclear foci and altered RNA metabolism. In addition, repeat- associated non-AUG (RAN) translation of the expanded GGGGCC- repeat sequence results in the production of highly toxic dipeptide- repeat (DPR) proteins. GGGGCC repeat-containing transcripts form G- quadruplexes, which are ass...
• Commercially traded fish portfolios mask household utilization of biodiversity in wild food systems AI翻译
  作者：Fiorella, Kathryn J.; Bageant, Elizabeth R.; Thilsted, Shakuntala H.; Heilpern, Sebastian A.
  作者单位：Cornell University; Cornell University
  摘要：The global biodiversity that underpins wild food systems-including fisheries-is rapidly declining. Yet, we often have only a limited understanding of how households use and benefit from biodiversity in the ecosystems surrounding them. Explicating these relationships is critical to forestall and mitigate the effects of biodiversity declines on food and nutrition security. Here, we quantify how biodiversity filters from ecosystems to household harvest, consumption, and sale, and how ecological t...
• The increasingly dominant role of climate change on length of day variations AI翻译
  作者：Kianishahvandi, Mostafa Kiani; Adhikari, Surendra; Dumberry, Mathieu; Mishra, Siddhartha; Soja, Benedikt
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); University of Alberta; Swiss Federal Institutes of Technology Domain; ETH Zurich
  摘要：The melting of ice sheets and global glaciers results in sea-level rise, a pole-to-equator mass transport increasing Earth's oblateness and resulting in an increase in the length of day (LOD). Here, we use observations and reconstructions of mass variations at the Earth's surface since 1900 to show that the climate-induced LOD trend hovered between 0.3 and 1.0 ms/cy in the 20th century, but has accelerated to 1.33 +/- 0.03 ms/cy since 2000. We further show that surface mass transport fully exp...
• A ∼40-kb flavi- like virus does not encode a known error- correcting mechanism AI翻译
  作者：Petrone, Mary E.; Grove, Joe; Melade, Julien; Mifsud, Jonathon C. O.; Parry, Rhys H.; Marzinelli, Ezequiel M.; Holmes, Edward C.
  作者单位：University of Sydney; University of Glasgow; University of Queensland; University of Sydney
  摘要：It is commonly held that there is a fundamental relationship between genome size and error rate, manifest as a notional error threshold that sets an upper limit on genome sizes. The genome sizes of RNA viruses, which have intrinsically high mutation rates due to a lack of mechanisms for error correction, must therefore be small to avoid accumulating an excessive number of deleterious mutations that will ultimately lead to population extinction. The proposed exceptions to this evolutionary rule...
• A transient radial cortical microtubule array primes cell division in Arabidopsis AI翻译
  作者：Melogno, Isaty; Takatani, Shogo; Llanos, Paula; Goncalves, Coralie; Kodera, Chie; Martin, Marjolaine; Lionnet, Claire; Uyttewaal, Magalie; Pastuglia, Martine; Trehin, Christophe; Bouchez, David; Dumais, Jacques; Hamant, Olivier
  作者单位：INRAE; Centre National de la Recherche Scientifique (CNRS); Ecole Normale Superieure de Lyon (ENS de LYON); Universite Claude Bernard Lyon 1; Nagoya University; Universidad Adolfo Ibanez; Universite Paris Saclay; INRAE; AgroParisTech
  摘要：Although the formation of new walls during plant cell division tends to follow maximal tensile stress direction, analyses of individual cells over time reveal a much more variable behavior. The origin of such variability as well as the exact role of interphasic micro- tubule behavior before cell division have remained mysterious so far. To approach this question, we took advantage of the Arabidopsis stem, where the tensile stress pattern is both highly anisotropic and stable. Although cortical...
• Germline BARD1 variants predispose to mesothelioma by impairing DNA repair and calcium signaling AI翻译
  作者：Novelli, Flavia; Yoshikawa, Yoshie; Vitto, Veronica Angela Maria; Modesti, Lorenzo; Minaai, Michael; Pastorino, Sandra; Emi, Mitsuru; Kim, Jin-Hee; Kricek, Franz; Bai, Fang; Onuchic, Jose N.; Bononi, Angela; Suarez, Joelle S.; Tanji, Mika; Favaron, Cristina; Zolondick, Alicia A.; Xu, Ronghui; Takanishi, Yasutaka; Wang, Zhanwei; Sakamoto, Greg; Gaudino, Giovanni; Grzymski, Joseph; Grosso, Federica; Schrump, David S.; Pass, Harvey I.; Atanesyan, Lilit; Smout, Jan; Savola, Suvi; Sarin, Kavita Y.; Abolhassani, Hassan; Hammarstrom, Lennart; Pan-Hammarstrom, Qiang; Giorgi, Carlotta; Pinton, Paolo; Yang, Haining; Carbone, Michele
  作者单位：University of Hawaii System; Cancer Research Center of Hawaii; Hyogo Medical University; University of Ferrara; ShanghaiTech University; Rice University; University of Hawaii System; University of Hawaii Manoa; Nevada System of Higher Education (NSHE); Desert Research Institute NSHE; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); New York University; Stanford University; Karolinska Institutet
  摘要：We report that similar to 1.8% of all mesothelioma patients and 4.9% of those younger than 55, carry rare germline variants of the BRCA1 associated RING domain 1 ( BARD1) gene that were predicted to be damaging by computational analyses. We conducted functional assays, essential for accurate interpretation of missense variants, in primary fibroblasts that we established in tissue culture from a patient carrying the heterozygous BARD1 V523A mutation. We found that these cells had genomic instab...