Proceedings of the National Academy of Sciences of the United States of America

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• Significant shifts in latitudinal optima of North American birds AI翻译
  作者：Martins, Paulo Mateus; Anderson, Marti J.; Sweatman, Winston L.; Punnett, Andrew J.
  作者单位：Massey University; Massey University
  摘要：Changes in climate can alter environmental conditions faster than most species can adapt. A prediction under a warming climate is that species will shift their distributions poleward through time. While many studies focus on range shifts, latitudinal shifts in species' optima can occur without detectable changes in their range. We quantified shifts in latitudinal optima for 209 North American bird species over the last 55 y. The latitudinal optimum (m) for each species in each year was estimat...
• Cross-prediction-powered inference AI翻译
  作者：Zrnic, Tijana; Candes, Emmanuel J.
  作者单位：Stanford University; Stanford University; Stanford University
  摘要：While reliable data-driven decision-making hinges on high-quality labeled data, the and expensive scientific measurements. Machine learning is becoming an appealing from satellite imagery are used to supplement accurate survey data, and so on. Since the validity of downstream inferences. We introduce cross-prediction: a method for valid inference powered by machine learning. With a small labeled dataset and a large unlabeled dataset, cross-prediction imputes the missing labels via machine lear...
• Synthesis of bioengineered heparin chemically and biologically similar to porcine- derived products and convertible to low MW heparin AI翻译
  作者：Douaisi, Marc; Paskaleva, Elena E.; Fu, Li; Grover, Navdeep; McManaman, Charity L.; Varghese, Sony; Brodfuehrer, Paul R.; Gibson, James M.; de Joode, Ian; Xia, Ke; Brier, Matthew I.; Simmons, Trevor J.; Datta, Payel; Zhang, Fuming; Onishi, Akihiro; Hirakane, Makoto; Mori, Daisuke; Linhardt, Robert J.; Dordick, Jonathan S.
  作者单位：Rensselaer Polytechnic Institute; Rensselaer Polytechnic Institute; Rensselaer Polytechnic Institute; Rensselaer Polytechnic Institute; Rensselaer Polytechnic Institute
  摘要：Heparins have been invaluable therapeutic anticoagulant polysaccharides for over a century, whether used as unfractionated heparin or as low molecular weight heparin (LMWH) derivatives. However, heparin production by extraction from animal tissues presents multiple challenges, including the risk of adulteration, contamination, prion and viral impurities, limited supply, insecure supply chain, and significant batch - to - batch variability. The use of animal- derived heparin also raises ethical...
• Intimate contact between red blood cells and vessel walls is sufficient to stabilize capillary networks during development AI翻译
  作者：Lorthois, Sylvie
  作者单位：Universite de Toulouse; Universite Federale Toulouse Midi-Pyrenees (ComUE); Universite Toulouse III - Paul Sabatier; Institut National Polytechnique de Toulouse; Centre National de la Recherche Scientifique (CNRS)
• Reply to Eichbichler et al.: Phase separation boosts HECT E3-mediated polyubiquitination AI翻译
  作者：Zhu, Kang; Li, Jingyu; Wen, Wenyu
  作者单位：Fudan University; Fudan University
• Glucuronic acid confers colonization advantage to enteric pathogens AI翻译
  作者：Rosay, Thibaut; Jimenez, Angel G.; Sperandio, Vanessa
  作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Texas System; University of Texas Southwestern Medical Center
  摘要：Glucuronidation is a detoxification process to eliminate endo- and xeno- biotics and neurotransmitters from the host circulation. Glucuronosyltransferase binds these compounds to glucuronic acid (GlcA), deactivating them and allowing their elimination through the gastrointestinal (GI) tract. However, the microbiota produces beta- glucuronidases that release GlcA and reactivate these compounds. Enteric pathogens such as enterohemorrhagic Escherichia coli (EHEC) and Citrobacter rodentium sense a...
• Phosphocholine-induced energy source shift alleviates mitochondrial dysfunction in lung cells caused by geospecific PM2.5 components AI翻译
  作者：Song, Yuanyuan; Zhang, Yanhao; Zhu, Lin; Chen, Yanyan; Chen, Yi-Jie; Zhu, Zhitong; Feng, Jieqing; Qi, Zenghua; Yu, Jian Zhen; Yang, Zhu; Cai, Zongwei
  作者单位：Hong Kong Baptist University; Guangdong University of Technology; Hong Kong University of Science & Technology; Hong Kong Baptist University
  摘要：Fine particulate matter (PM2.5) is globally recognized for its adverse implications on human health. Yet, remain limited the individual contribution of particular PM2.5 components to its toxicity, especially considering regional disparities. Moreover, prevention solutions for PM2.5- associated health effects are scarce. In the present study, we comprehensively characterized and compared the primary PM2.5 constituents and their altered metabolites from two locations: Taiyuan and Guangzhou. Anal...
• Sea-surface temperature pattern effects have slowed globalwarming and biased warming-based constraints on climatesensitivity AI翻译
  作者：Armour, Kyle C.; Proistosescu, Cristian; Dong, Yue; Hahn, Lily C.; Blanchard-Wrigglesworth, Edward; Pauling, Andrew G.; Wills, Robert C. Jnglin; Andrews, Timothy; Stuecker, Malte F.; Po-Chedley, Stephen; Mitevski, Ivan; Forster, Piers M.; Gregory, Jonathan M.
  作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Illinois System; University of Illinois Urbana-Champaign; University of Colorado System; University of Colorado Boulder; University of California System; University of California San Diego; Scripps Institution of Oceanography; University of Otago; Swiss Federal Institutes of Technology Domain; ETH Zurich; Met Office - UK; Hadley Centre; University of Hawaii System; University of Hawaii Manoa; University of Hawaii System; University of Hawaii Manoa; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; Columbia University; University of Leeds; University of Reading; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC National Centre for Atmospheric Science
  摘要：The observed rate of global warming since the 1970s has been proposed as a strongconstraint on equilibrium climate sensitivity (ECS) and transient climate response(TCR)-key metrics of the global climate response to greenhouse-gas forcing. UsingCMIP5/6 models, we show that the inter-model relationship between warming andthese climate sensitivity metrics (the basis for the constraint) arises from a similarityin transient and equilibrium warming patterns within the models, producing aneffective c...
• Policies, projections, and the social cost of carbon: Results from the DICE-2023 model AI翻译
  作者：Barrage, Lint; Nordhaus, William
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Yale University; National Bureau of Economic Research
  摘要：The present study examines the assumptions, modeling structure, and results of DICE - 2023, the revised Dynamic Integrated Model of Climate and the Economy (DICE), updated to 2023. The revision contains major changes in the treatment of risk, the carbon and climate modules, the treatment of nonindustrial greenhouse gases, discount rates, as well as updates on all the major components. Noteworthy changes are a significant reduction in the target for the optimal (cost- beneficial) temperature pa...
• Too old for hide- and- seek: Cell maturation reveals hidden apical junctional organization AI翻译
  作者：Jensen, Corbin C.; Peifer, Mark
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill