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作者：Hazra, Nabanita; Rudov, Andrey A.; Midya, Jiarul; Babenyshev, Andrey; Bochenek, Steffen; Frenken, Martin; Richtering, Walter; Gompper, Gerhard; Auth, Thorsten; Potemkin, Igor I.; Crassous, Jerome J.
作者单位：RWTH Aachen University; Leibniz Association; DWI Leibniz Institute for Interactive Materials; Lomonosov Moscow State University; Helmholtz Association; Research Center Julich; Helmholtz Association; Research Center Julich
摘要：The adsorption of ellipsoidal colloidal particles on liquid interfaces induces interfacial deformation, resulting in anisotropic interface-mediated interactions and the formation of superstructures. Soft prolate-shaped microgels at the air-water interface offer an ideal model for studying spontaneous capillary-driven self-assembly due to their tunable aspect ratio, controlled functionality, and softness. These microgels consist of a polystyrene core surrounded by a cross-linked, fluorescently ...
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作者：Hessel, Anthony L.; Kuehn, Michel N.; Palmer, Bradley M.; Nissen, Devin; Mishra, Dhruv; Joumaa, Venus; Freundt, Johanna K.; Ma, Weikang; Nishikawa, Kiisa C.; Irving, Thomas C.; Linke, Wolfgang A.
作者单位：University of Munster; University of Vermont; Illinois Institute of Technology; Northern Arizona University; University of Calgary; University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; German Centre for Cardiovascular Research
摘要：In muscle, titin proteins connect myofilaments together and are thought to be critical for contraction, especially during residual force enhancement (RFE) when steady- state force is elevated after an active stretch. We investigated titin's function during contraction using small- angle X- ray diffraction to track structural changes before and after 50% titin cleavage and in the RFE- deficient, mdm titin mutant. We report that the RFE state is structurally distinct from pure isometric contract...
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作者：Hubbard, Kevin M.; Elkins-Tanton, Linda T.; Masson-Zwaan, Tanja
作者单位：Arizona State University; Arizona State University-Tempe; Leiden University; Leiden University - Excl LUMC
摘要：Despite the increasing number of space launches, growth of the commercial space sector, signing of the Artemis Accords, maturation of space mining technologies, the emergence of a regulatory environment through domestic legislation, and a comprehensive body of international law, an intergovernmental governing authority has yet to be established to manage mining activities on the Moon. We developed a Lunar Mining Code and mapping tool to regulate and manage prospecting and exploration activitie...
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作者：Jakosky, Bruce M.
作者单位：University of Colorado System; University of Colorado Boulder
摘要：Understanding the history of water on Mars is important for understanding both its geological and potential biological history. The abundance and physical state of water has evolved through time, from the surface having an early warmer and wetter environment to the present- day colder and drier one. Although multiple lines of evidence support this change, attempts to determine the abundance of water on the planet, the history of water at the surface, and the sequestration into both permanent a...
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作者：Patel, Aum R.; Garg, Amit; Rosberger, Haylen T.; Kowdle, Shreyas; Reis, Rebecca A.; Frere, Justin J.; Januska, Megan N.; Dawodu, Gbalekan; Valencia, Estefania; Yang, Min-Chi; Stevens, Christian S.; Rao, Vishal N.; Haas, Griffin D.; Chen, Ya-Wen; Lee, Benhur; Lim, Jean K.
作者单位：Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai
摘要：Formerly a common childhood pathogen, mumps virus (MuV) remains active worldwide, despite relatively high vaccine coverage. MuV is thought to infect the upper respiratory tract before disseminating to other organs; however, the early cellular targets of MuV in vivo are unknown. To address this, we generated a green fluorescent protein (GFP)- tagged vaccine strain (JL5) of MuV to infect leukocytic cell lines and found that replication was greatest in monocytes. Infection of peripheral blood mon...
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作者：Raffi, Gabriele Casagrande; Chen, Jian; Feng, Xuezhao; Chen, Zhen; Lieftink, Cor; Deng, Shuang; Mo, Jinzhe; Zeng, Chuting; Steur, Marit; Wang, Jing; Bleijerveld, Onno B.; Hoekman, Liesbeth; van der Wel, Nicole; Wang, Feng; Beijersbergen, Roderick; Zheng, Jian; Bernards, Rene; Wang, Liqin
作者单位：Netherlands Cancer Institute; Sun Yat Sen University; State Key Lab Oncology South China; Netherlands Cancer Institute; Netherlands Cancer Institute; University of Amsterdam
摘要：Drugs that eliminate senescent cells, senolytics, can be powerful when combined with here SLC25A23 as a vulnerability of senescent cancer cells. Suppressing SLC25A23 disrupts cellular calcium homeostasis, impairs oxidative phosphorylation, and interferes with redox signaling, leading to death of senescent cells. These effects can be replicated by salinomycin, a cation ionophore antibiotic. Salinomycin prompts a pyroptosis- apoptosis- necroptosis (PAN)optosis- like cell death in senescent cells...
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作者：Shearer, Charles K.; Sharp, Zachary D.; Stopar, Julie
作者单位：University of New Mexico; University of New Mexico; Universities Space Research Association (USRA)
摘要：Numerous missions to the Moon have identified and documented volatile deposits associated with permanently shadowed regions. A series of science goals for the Artemis Program is to explore these volatile deposits and return samples to Earth. Volatiles in these reservoirs may consist of a variety of species whose stable isotope characteristics could elucidate both their sources and the processes instrumental in their formation. For example, the delta D of potential contributors to the deposits ...
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作者：Thiemens, Mark H.; Pack, Andreas; Sharp, Zachary
作者单位：University of California System; University of California San Diego; University of Gottingen; University of New Mexico
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作者：Zhou, Yangyang; Liu, Pengtao; Tang, Yaqi; Liu, Jie; Tang, Yaru; Zhuang, Yumeng; Li, Xiaoting; Xu, Kaiqi; Zhou, Zhi; Li, Jigang; He, Guangming; Deng, Xing Wang; Yang, Li
作者单位：China Agricultural University; Peking University; Peking University; China Agricultural University; Peking University
摘要：Light is a major determinant of plant growth and survival. NONEXPRESSER OF PATHOGENESIS- RELATED GENES 1 (NPR1) acts as a receptor for salicylic acid (SA) and serves as the key regulator of SA- mediated immune responses. However, the mechanisms by which plants integrate light and SA signals in response to environmental changes, as well as the role of NPR1 in regulating plant photomorphogenesis, remain poorly understood. This study shows that SA promotes plant photomorphogenesis by regulating P...
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作者：Lie-Panis, Julien; Fitouchi, Leo; Baumard, Nicolas; Andre, Jean-Baptiste
作者单位：Max Planck Society; Universite PSL; Ecole Normale Superieure (ENS); Centre National de la Recherche Scientifique (CNRS); Universite de Toulouse; Universite Toulouse 1 Capitole; Toulouse School of Economics
摘要：Institutions allow cooperation to persist when reciprocity and reputation provide insufficient incentives. Yet how they do so remains unclear, especially given that institutions are themselves a form of cooperation. To solve this puzzle, we develop a mathematical model of reputation-based cooperation in which two social dilemmas are nested within one another. The first dilemma, characterized by high individual costs or insufficient monitoring, cannot be solved by reputation alone. The second d...
