Proceedings of the National Academy of Sciences of the United States of America

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• Gate-tunable subband degeneracy in semiconductor nanowires AI翻译
  作者：Wang, Yuhao; Song, Wenyu; Cao, Zhan; Yu, Zehao; Yang, Shuai; Li, Zonglin; Gao, Yichun; Li, Ruidong; Chen, Fangting; Geng, Zuhan; Yang, Lining; Xu, Jiaye; Wang, Zhaoyu; Zhang, Shan; Feng, Xiao; Wang, Tiantian; Zang, Yunyi; Li, Lin; Shang, Runan; Xue, Qi-Kun; Liu, Dong E.; He, Ke; Zhang, Hao
  作者单位：Tsinghua University; Beijing Academy of Quantum Information Sciences; Hefei National Laboratory; Southern University of Science & Technology
  摘要：Degeneracy and symmetry have a profound relation in quantum systems. Here, we report gate -tunable subband degeneracy in PbTe nanowires with a nearly symmetric cross-sectional shape. The degeneracy is revealed in electron transport by the absence of a quantized plateau. Utilizing a dual gate design, we can apply an electric field to lift the degeneracy, reflected as emergence of the plateau. This degeneracy and its tunable lifting were challenging to observe in previous nanowire experiments, p...
• The biophysical landscape of viral evolution AI翻译
  作者：Wilke, Claus O.
  作者单位：University of Texas System; University of Texas Austin
• Alanine synthesized by alanine dehydrogenase enables ammonium- tolerant nitrogen fixation in Paenibacillus sabinae T27 (vol 119, e2215855119, 2022) AI翻译
  作者：Li, Qin; Zhang, Haowei; Song, Yi; Wang, Minyang; Hua, Chongchong; Li, Yashi; Chen, Sanfeng; Dixon, Ray; Li, Jilun
• Geospatial joint modeling of vector and parasite serology to microstratify malaria transmission AI翻译
  作者：Kearney, Ellen A.; Amratia, Punam; Kang, Su Yun; Agius, Paul A.; Alene, Kefyalew Addis; O'Flaherty, Katherine; Oo, Win Han; Cutts, Julia C.; Htike, Win; Goncalves, Daniela Da Silva; Razook, Zahra; Barry, Alyssa E.; Drew, Damien; Thi, Aung; Aung, Kyaw Zayar; Thu, Htin Kyaw; Thein, Myat Mon; Zaw, Nyi Nyi; Htay, Wai Yan Min; Soe, Aung Paing; Beeson, James G.; Simpson, Julie A.; Gething, Peter W.; Cameron, Ewan; Fowkes, Freya J. I.
  作者单位：Burnet Institute; University of Melbourne; The Kids Research Institute Australia; University of Western Australia; Deakin University; Curtin University; University of Melbourne; Peter Doherty Institute; Deakin University; University of Melbourne; Monash University; Monash University; Monash University
  摘要：The World Health Organization identifies a strong surveillance system for malaria and its mosquito vector as an essential pillar of the malaria elimination agenda. Anopheles salivary antibodies are emerging biomarkers of exposure to mosquito bites that potentially overcome sensitivity and logistical constraints of traditional entomological surveys. Using samples collected by a village health volunteer network in 104 villages in Southeast Myanmar during routine surveillance, the present study e...
• Prebiotic chemical reactivity in solution with quantum accuracy and microsecond sampling using neural network potentials AI翻译
  作者：Benayad, Zakarya; David, Rolf; Stirnemann, Guillaume
  作者单位：Centre National de la Recherche Scientifique (CNRS); Universite PSL; Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Universite PSL; Ecole Normale Superieure (ENS)
  摘要：While RNA appears as a good candidate for the first autocatalytic systems preceding the emergence of modern life, the synthesis of RNA oligonucleotides without enzymes remains challenging. Because the uncatalyzed reaction is extremely slow, experimental studies bring limited and indirect information on the reaction mechanism, the nature of which remains debated. Here, we develop neural network potentials (NNPs) to study the phosphoester bond formation in water. While NNPs are becoming routinel...
• RNA polymerase tracking along damaged DNA: Impact on DNA repair and mutagenesis AI翻译
  作者：Chiou, Yi-Ying; Kemp, Michael G.
  作者单位：National Chung Hsing University; University System of Ohio; Wright State University Dayton
• Reply to Nebo et al.: Pathogenesis of advanced hidradenitis suppurativa: Are there differences based on anatomical location, gender, and race? AI翻译
  作者：Jin, Lin; Kashyap, Mahendra P.; Haque, Safiya T.; Li, Changzhao; Raman, Chander; Athar, Mohammad
  作者单位：University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham
• The dominance and growth of shallow groundwater resources in continuous permafrost environments AI翻译
  作者：Koch, Joshua C.; Connolly, Craig T.; Baughman, Carson; Repasch, Marisa; Best, Heather; Hunt, Andrew
  作者单位：United States Department of the Interior; United States Geological Survey; University of Texas System; University of Texas Austin; University of Colorado System; University of Colorado Boulder; United States Department of the Interior; United States Geological Survey; United States Department of the Interior; United States Geological Survey; United States Environmental Protection Agency
  摘要：Water is a limited resource in Arctic watersheds with continuous permafrost because freezing conditions in winter and the impermeability of permafrost limit storage and connectivity between surface water and deep groundwater. However, groundwater can still be an important source of surface water in such settings, feeding springs and large aufeis fields that are abundant in cold regions and generating runoff when precipitation is rare. Whether groundwater is sourced from suprapermafrost taliks ...
• Atomic resolution structure of full- length human insulin fibrils AI翻译
  作者：Suladze, Saba; Sarkar, Riddhiman; Rodina, Natalia; Bokvist, Krister; Krewinkel, Manuel; Scheps, Daniel; Nagel, Norbert; Bardiaux, Benjamin; Reif, Bernd
  作者单位：Technical University of Munich; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Sanofi-Aventis; Sanofi Germany; Sanofi-Aventis; Sanofi Germany; Sanofi-Aventis; Sanofi Germany; Sanofi-Aventis; Sanofi Germany; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Neurocrine Biosciences; AbbVie
  摘要：Patients with type 1 diabetes mellitus who are dependent on an external supply of insulin develop insulin - derived amyloidosis at the sites of insulin injection. A major component of these plaques is identified as full - length insulin consisting of the two chains A and B. While there have been several reports that characterize insulin misfolding and the biophysical properties of the fibrils, atomic - level information on the insulin fibril architecture remains elusive. We present here an ato...
• Type VII secretion system extracellular protein B targets STING to evade host anti- Staphylococcus aureus immunity AI翻译
  作者：Gao, Lin; Tian, Tian; Xiong, Tingrong; Zhang, Xiaomei; Wang, Ning; Liu, Luxuan; Shi, Yun; Liu, Qiang; Lu, Dongshui; Luo, Ping; Zhang, Weijun; Cheng, Ping; Gou, Qiang; Wang, Yu; Zeng, Hao; Zhang, Xiaokai; Zou, Quanming
  作者单位：Army Medical University; Army Medical University; Sichuan University; Army Medical University; Army Medical University
  摘要：Staphylococcus aureus ( S. aureus ) can evade antibiotics and host immune defenses by persisting within infected cells. Here, we demonstrate that in infected host cells, S. aureus type VII secretion system (T7SS) extracellular protein B (EsxB) interacts with the stimulator of interferon genes (STING) protein and suppresses the inflammatory defense mechanism of macrophages during early infection. The binding of EsxB with STING disrupts the K48 - linked ubiquitination of EsxB at lysine 33, there...