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作者：Renault, Thomas; Mosleh, Mohsen; Rand, David G.
作者单位：Centre National de la Recherche Scientifique (CNRS); University of Oxford; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
摘要：We use crowd-sourced assessments from X's Community Notes program to examine whether there are partisan differences in the sharing of misleading information. Unlike previous studies, misleadingness here is determined by agreement across a diverse community of platform users, rather than by fact-checkers. We find that 2.3 times more posts by Republicans are flagged as misleading compared to posts by Democrats. These results are not base rate artifacts, as we find no meaningful overrepresentatio...
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作者：Ganslmeier, Michael; Vlandas, Tim
作者单位：University of Exeter; University of Oxford
摘要：Assessing model uncertainty is crucial to quantitative political science. Yet, most available sensitivity analyses focus only on a few modeling choices, most notably the covariate space, while neglecting to jointly consider several equally important modeling choices simultaneously. In this article, we combine the exhaustive and systematic method of the Extreme Bounds Analysis with the more multidimensional logic underpinning the multiverse approach to develop an approach to sensitivity analyse...
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作者：Kalle, Anagha; Wu, Jian; Tawfeeq, Caesar; Kornev, Alexandr P.; Veglia, Gianluigi; Maillard, Rodrigo; Taylor, Susan S.; Jonniya, Nisha Amarnath
作者单位：Johns Hopkins University; University of California System; University of California San Diego; University of California System; University of California San Diego; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; Georgetown University; Georgetown University; National Institute of Technology (NIT System); National Institute of Technology Andhra Pradesh
摘要：Cushing's syndrome (CS) is an abnormal condition characterized by elevated cortisol levels, often resulting from genetic alterations in the PRKACA gene, which encodes the catalytic subunit of cAMP-dependent protein kinase A (PKA-C). The most common CS mutation, L205R, lies at the P + 1 loop. Understanding how this mutation alters the internal allosteric network within PKA-C and changes nucleotide and substrate cooperativity is a major goal. Using molecular dynamics (MD) simulations and protein...
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作者：Meirmans, Patrick G.; Kolar, Filip
作者单位：University of Amsterdam; Charles University Prague; Czech Academy of Sciences; Institute of Botany of the Czech Academy of Sciences
摘要：Polyploidization (whole-genome duplication, WGD) is a widespread large-effect macromutation with far-reaching genomic, phenotypic, and evolutionary consequences. Yet, we do not know whether the consistent phenotypic changes that are associated with polyploidization translate into predictable changes in ecological preferences. Niche modeling studies in mixed-ploidy species provide an opportunity to compare recently originated polyploids with their lower-ploidy ancestors. However, the available ...
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作者：Palomero, Orhi Esarte; Guadarrama, Eduardo; DeCaen, Paul G.
作者单位：Northwestern University; Feinberg School of Medicine; Northwestern University
摘要：PKD2 is a member of the polycystin subfamily of transient receptor potential (TRP) ion channel subunits which traffic and function in primary cilia organelle membranes. Millions of individuals carry pathogenic genetic variants in PKD2 that cause a life-threatening condition called autosomal dominant polycystic kidney disease (ADPKD). Although ADPKD is a common monogenetic disorder, there is no drug cure or available therapeutics which address the underlying channel dysregulation. Furthermore, ...
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作者：Sun, Xianhu; Wu, Dongxiang; Wang, Jianyu; Patel, Shyam B.; Zhu, Wenhui; Yang, Ji; Yang, Timothy T.; Ye, Shuonan; Chen, Xiaobo; Zhu, Yaguang; Qiao, Linna; Li, Meng; House, Stephen D.; Su, Ji; Saidi, Wissam A.; Boscoboinik, Jorge Anibal; Yang, Judith C.; Sharma, Renu; Zhou, Guangwen
作者单位：State University of New York (SUNY) System; Binghamton University, SUNY; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; United States Department of Energy (DOE); Brookhaven National Laboratory; National Institute of Standards & Technology (NIST) - USA
摘要：The breaking of translational symmetry at oxide surfaces gives rise to coordinatively unsaturated cations/anions and surface restructuring-key factors that govern surface reactivity. Using direct in situ environmental transmission electron microscopy (TEM) observations along with atomistic modeling, we report oscillatory redox behavior in CuO under H2, where cyclic surface reconstruction and reactivity modulation occur via the Mars-van Krevelen (MvK) mechanism. We observe self-switching betwee...
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作者：Xiao, Junli; Nakamura, Yoko; Wu, Zhixin; Fu, Wenjie; Chen, Yumeng; Lou, Yonggen; Baldwin, Ian T.; Boland, Wilhelm; Li, Ran
作者单位：Zhejiang University; Max Planck Society; Max Planck Society; Max Planck Society; Max Planck Society
摘要：Herbivore attack elicits jasmonate (JA) signaling which in turn elicits both anti-herbivore plant defenses and growth inhibitions. The resulting growth-defense trade-offs constrain the utility of JA-based plant defense inducers to enhance endogenous pest resistance. Here, we designed and screened selective JA receptor agonists by synthesizing 6-substituted 1-oxoindanoyl isoleucine (In-Ile) conjugates and their free-acid forms, structural mimics of the bioactive hormone (+)-7-iso-jasmonoyl-L-Il...
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作者：Zarri, Liam J.; Kraft, Clifford E.; Mcintyre, Peter B.; Baetscher, Diana S.; Jirka, Kurt J.; Randall, Eileen A.; Quay, Benjamin Marcy -; St John, Carl A.; Sethi, Suresh A.; Airey, Montana E.; Detmer, Thomas M.; Flecker, Alexander S.; Therkildsen, Nina O.
作者单位：Cornell University; Cornell University; National Oceanic Atmospheric Admin (NOAA) - USA; United States Department of the Interior; United States Geological Survey; City University of New York (CUNY) System; Brooklyn College (CUNY)
摘要：Species invasions spur costly and labor-intensive control efforts, yet even local eradication is seldom achieved. When control measures are initially effective, they may drive evolutionary adaptation that prevents full eradication, as has been documented for some chemical and biocontrol approaches. Although the intensity, directionality, and persistence of selection required to increase the frequency of resistant genotypes in complex natural ecosystems remains an open question, theory predicts...
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作者：Ivanovska, Irena L.
作者单位：University of Pennsylvania
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作者：Sun, Youbin; Wang, Ting; Yin, Qiuzhen; Clemens, Steven C.; Liu, Xingxing; Ai, Li; Wu, Zhipeng; Qiang, Xiaoke; Wang, Xulong; Chang, Hong; Song, Yougui; Vogel, Hendrik; Dodson, John; Berger, Andre; An, Zhisheng
作者单位：Chinese Academy of Sciences; Institute of Earth Environment, CAS; Hubei Engineering University; Universite Catholique Louvain; Brown University; University of Bern; University of Bern; University of New South Wales Sydney; Laoshan Laboratory
摘要：Observational and modeling results show that the frequency and amplitude of extreme climatic events have increased significantly in the context of global warming. However, whether abrupt climate changes intensified during past warm periods remains poorly constrained due to the lack of high- resolution geological records. Here, we report a 512- m predominantly lacustrine sedimentary record from the Weihe Basin (North China), revealing that lake levels fluctuated significantly on suborbital (hal...
