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作者：Braxton, Alicia M.; Kiemen, Ashley L.; Grahn, Mia P.; Forjaz, Andre; Parksong, Jeeun; Babu, Jaanvi Mahesh; Lai, Jiaying; Zheng, Lily; Niknafs, Noushin; Jiang, Liping; Cheng, Haixia; Song, Qianqian; Reichel, Rebecca; Graham, Sarah; Damanakis, Alexander I.; Fischer, Catherine G.; Mou, Stephanie; Metz, Cameron; Granger, Julie; Liu, Xiao-Ding; Bachmann, Niklas; Zhu, Yutong; Liu, YunZhou; Almagro-Perez, Cristina; Jiang, Ann Chenyu; Yoo, Jeonghyun; Kim, Bridgette; Du, Scott; Foster, Eli; Hsu, Jocelyn Y.; Rivera, Paula Andreu; Chu, Linda C.; Liu, Fengze; Fishman, Elliot K.; Yuille, Alan; Roberts, Nicholas J.; Thompson, Elizabeth D.; Scharpf, Robert B.; Cornish, Toby C.; Jiao, Yuchen; Karchin, Rachel; Hruban, Ralph H.; Wu, Pei-Hsun; Wirtz, Denis; Wood, Laura D.
作者单位：Johns Hopkins University; Medical University of South Carolina; Johns Hopkins University; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins University; Chinese Academy of Medical Sciences - Peking Union Medical College; Cancer Institute & Hospital - CAMS; Peking Union Medical College; Chinese Academy of Medical Sciences - Peking Union Medical College; Cancer Institute & Hospital - CAMS; Peking Union Medical College; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Peking Union Medical College Hospital; Johns Hopkins University; Johns Hopkins University; University of Colorado System; University of Colorado Anschutz Medical Campus; Henan Academy of Innovations in Medical Science; Johns Hopkins University
摘要：Pancreatic intraepithelial neoplasias (PanINs) are the most common precursors of pancreatic cancer, but their small size and inaccessibility in humans make them challenging to study(1). Critically, the number, dimensions and connectivity of human PanINs remain largely unknown, precluding important insights into early cancer development. Here, we provide a microanatomical survey of human PanINs by analysing 46 large samples of grossly normal human pancreas with a machine-learning pipeline for q...
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作者：Gibney, Elizabeth
摘要：Timekeepers based on energy shifts in atomic nuclei could transform fundamental-physics research.
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作者：Weis, Jakob; Chase, Zanna; Schallenberg, Christina; Strutton, Peter G.; Bowie, Andrew R.; Fiddes, Sonya L.
作者单位：University of Tasmania; University of Tasmania; University of Tasmania; University of Tasmania; Commonwealth Scientific & Industrial Research Organisation (CSIRO); CSIRO Environment
摘要：Natural iron fertilization of the Southern Ocean by windblown dust has been suggested to enhance biological productivity and modulate the climate(1-3). Yet, this process has never been quantified across the Southern Ocean and at annual timescales(4,5). Here we combined 11years of nitrate observations from autonomous biogeochemical ocean profiling floats with a Southern Hemisphere dust simulation to empirically derive the relationship between dust-iron deposition and annual net community produc...
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作者：Weissman, Myrna M.; Mootz, Jennifer J.
作者单位：Columbia University
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作者：Classen, Anne-Kathrin
作者单位：University of Freiburg; University of Freiburg
摘要：Researchers find that brief and reversible inhibition of a gene-silencing mechanism leads to irreversible tumour formation in fruit flies, challenging the idea that cancer is caused only by permanent changes to DNA.
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作者：Son, Yeeun; Kenny, Timothy C.; Khan, Artem; Birsoy, Kivanc; Hite, Richard K.
作者单位：Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine; Rockefeller University
摘要：Phosphatidylcholine and phosphatidylethanolamine, the two most abundant phospholipids in mammalian cells, are synthesized de novo by the Kennedy pathway from choline and ethanolamine, respectively(1-6). Despite the essential roles of these lipids, the mechanisms that enable the cellular uptake of choline and ethanolamine remain unknown. Here we show that the protein encoded by FLVCR1, whose mutation leads to the neurodegenerative syndrome posterior column ataxia and retinitis pigmentosa(7-9), ...
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作者：Zindl, Carlene L.; Wilson, C. Garrett; Chadha, Awalpreet S.; Duck, Lennard W.; Cai, Baiyi; Harbour, Stacey N.; Nagaoka-Kamata, Yoshiko; Hatton, Robin D.; Gao, Min; Figge, David A.; Weaver, Casey T.
作者单位：University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham
摘要：Interleukin 22 (IL-22) has a non-redundant role in immune defence of the intestinal barrier(1-3). T cells, but not innate lymphoid cells, have an indispensable role in sustaining the IL-22 signalling that is required for the protection of colonic crypts against invasion during infection by the enteropathogen Citrobacter rodentium(4) (Cr). However, the intestinal epithelial cell (IEC) subsets targeted by T cell-derived IL-22, and how T cell-derived IL-22 sustains activation in IECs, remain unde...
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作者：[Anonymous]
摘要：Rich nations' fixation on forests as climate offsets has resulted in the needs of those who live in or make a living from these resources being ignored. A broader view and more collaboration between disciplines is required.
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作者：Radko-Juettner, Sandi; Yue, Hong; Myers, Jacquelyn A.; Carter, Raymond D.; Robertson, Alexis N.; Mittal, Priya; Zhu, Zhexin; Hansen, Baranda S.; Donovan, Katherine A.; Hunkeler, Moritz; Rosikiewicz, Wojciech; Wu, Zhiping; Mcreynolds, Meghan G.; Burman, Shourya S. Roy; Schmoker, Anna M.; Mageed, Nada; Brown, Scott A.; Mobley, Robert J.; Partridge, Janet F.; Stewart, Elizabeth A.; Pruett-Miller, Shondra M.; Nabet, Behnam; Peng, Junmin; Gray, Nathanael S.; Fischer, Eric S.; Roberts, Charles W. M.
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作者：Brlik, Vojtech
作者单位：Charles University Prague
