Nature

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• Nuclear genetic control of mtDNA copy number and heteroplasmy in humans (vol 620, pg 839, 2023) AI翻译
  作者：Gupta, Rahul; Kanai, Masahiro; Durham, Timothy J.; Tsuo, Kristin; McCoy, Jason G.; Kotrys, Anna V.; Zhou, Wei; Chinnery, Patrick F.; Karczewski, Konrad J.; Calvo, Sarah E.; Neale, Benjamin M.; Mootha, Vamsi K.
• STRAIGHT TALK ABOUT PERIODS AND FIELDWORK AI翻译
  作者：Walker, Cameron; Khosa, Rivoningo; McCerery, Becky; Das, Sampurna; Mangubhai, Sangeeta
  作者单位：University of Cape Town; Northumbria University; University of Delhi
• A site-resolved two-dimensional quantum simulator with hundreds of trapped ions AI翻译
  作者：Guo, S. -A.; Wu, Y. -K.; Ye, J.; Zhang, L.; Lian, W. -Q.; Yao, R.; Wang, Y.; Yan, R. -Y.; Yi, Y. -J.; Xu, Y. -L.; Li, B. -W.; Hou, Y. -H.; Xu, Y. -Z.; Guo, W. -X.; Zhang, C.; Qi, B. -X.; Zhou, Z. -C.; He, L.; Duan, L. -M.
  作者单位：Tsinghua University; Hefei National Laboratory
  摘要：A large qubit capacity and an individual readout capability are two crucial requirements for large-scale quantum computing and simulation(1). As one of the leading physical platforms for quantum information processing, the ion trap has achieved a quantum simulation of tens of ions with site-resolved readout in a one-dimensional Paul trap(2-4) and of hundreds of ions with global observables in a two-dimensional (2D) Penning trap(5,6). However, integrating these two features into a single system...
• A virally encoded high-resolution screen of cytomegalovirus dependencies AI翻译
  作者：Finkel, Yaara; Nachshon, Aharon; Aharon, Einav; Arazi, Tamar; Simonovsky, Elena; Dobesova, Martina; Saud, Zack; Gluck, Avi; Fisher, Tal; Stanton, Richard J.; Schwartz, Michal; Stern-Ginossar, Noam
  作者单位：Weizmann Institute of Science; Cardiff University
  摘要：Genetic screens have transformed our ability to interrogate cellular factor requirements for viral infections1,2, but most current approaches are limited in their sensitivity, biased towards early stages of infection and provide only simplistic phenotypic information that is often based on survival of infected cells2, 3-4. Here, by engineering human cytomegalovirus to express single guide RNA libraries directly from the viral genome, we developed virus-encoded CRISPR-based direct readout scree...
• DNA mismatch and damage patterns revealed by single-molecule sequencing AI翻译
  作者：Liu, Mei Hong; Costa, Benjamin M.; Bianchini, Emilia C.; Choi, Una; Bandler, Rachel C.; Lassen, Emilie; Gronska-Peski, Marta; Schwing, Adam; Murphy, Zachary R.; Rosenkjaer, Daniel; Picciotto, Shany; Bianchi, Vanessa; Stengs, Lucie; Edwards, Melissa; Nunes, Nuno Miguel; Loh, Caitlin A.; Truong, Tina K.; Brand, Randall E.; Pastinen, Tomi; Wagner, J. Richard; Skytte, Anne-Bine; Tabori, Uri; Shoag, Jonathan E.; Evrony, Gilad D.
  作者单位：New York University; New York University; New York University; University System of Ohio; Case Western Reserve University; University Hospitals of Cleveland; University of Toronto; Hospital for Sick Children (SickKids); Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Children's Mercy Hospital; University of Sherbrooke; University of Toronto; Hospital for Sick Children (SickKids)
  摘要：Mutations accumulate in the genome of every cell of the body throughout life, causing cancer and other diseases1,2. Most mutations begin as nucleotide mismatches or damage in one of the two strands of the DNA before becoming double-strand mutations if unrepaired or misrepaired3,4. However, current DNA-sequencing technologies cannot accurately resolve these initial single-strand events. Here we develop a single-molecule, long-read sequencing method (Hairpin Duplex Enhanced Fidelity sequencing (...
• Air sacs reduce energy costs for soaring birds AI翻译
  作者：Tobalske, Bret W.
  作者单位：University of Montana System; University of Montana
  摘要：Certain air sacs have evolved in multiple lineages of soaring birds, and it emerges that these probably function to reduce the force required from the major flight muscles as they hold the wings in place during gliding and soaring.
• High-speed and large-scale intrinsically stretchable integrated circuits (vol 627, pg 313, 2024) AI翻译
  作者：Zhong, Donglai; Wu, Can; Jiang, Yuanwen; Yuan, Yujia; Kim, Min-gu; Nishio, Yuya; Shih, Chien-Chung; Wang, Weichen; Lai, Jian-Cheng; Ji, Xiaozhou; Gao, Theodore Z.; Wang, Yi-Xuan; Xu, Chengyi; Zheng, Yu; Yu, Zhiao; Gong, Huaxin; Matsuhisa, Naoji; Zhao, Chuanzhen; Lei, Yusheng; Liu, Deyu; Zhang, Song; Ochiai, Yuto; Liu, Shuhan; Wei, Shiyuan; Tok, Jeffrey B. -H.; Bao, Zhenan
• The Sustainable Development Goals: can they be made smarter? AI翻译
  作者：[Anonymous]
  摘要：Accounting for factors such as artificial intelligence in a more ambitious set of goals has a lot of merit - as long as urgency is not lost on the existing ones.
• MICROWAVE MYSTERY AS SPACE OBJECT PUZZLES SCIENTISTS AI翻译
  作者：[Anonymous]
• The respiratory system influences flight mechanics in soaring birds AI翻译
  作者：Schachner, Emma R.; Moore, Andrew J.; Martinez, Aracely; Diaz, Raul E., Jr.; Echols, M. Scott; Atterholt, Jessie; Kissane, Roger W. P.; Hedrick, Brandon P.; Bates, Karl T.
  作者单位：State University System of Florida; University of Florida; State University of New York (SUNY) System; Stony Brook University; Stony Brook University Hospital; Louisiana State University System; Louisiana State University Health Sciences Center New Orleans; California State University System; California State University Los Angeles; Western University of Health Sciences; University of Liverpool; Cornell University
  摘要：The subpectoral diverticulum (SPD) is an extension of the respiratory system in birds that is located between the primary muscles responsible for flapping the wing(1,2). Here we survey the pulmonary apparatus in 68 avian species, and show that the SPD was present in virtually all of the soaring taxa investigated but absent in non-soarers. We find that this structure evolved independently with soaring flight at least seven times, which indicates that the diverticulum might have a functional and...