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作者：Wang, Mingyang; Liu, Shihan; Liu, Hao; Wang, Yujie; Lan, Yu; Liu, Qiang
作者单位：Tsinghua University; Henan University; Chongqing University; Zhengzhou University
摘要：Asymmetric catalysis enables the synthesis of optically active compounds, often requiring the differentiation between two substituents on prochiral substrates(1). Despite decades of development of mainly noble metal catalysts, achieving differentiation between substituents with similar steric and electronic properties remains a notable challenge(2,3). Here we introduce a class of Earth-abundant manganese catalysts for the asymmetric hydrogenation of dialkyl ketimines to give a range of chiral ...
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作者：Tsukui, Tatsuya; Wolters, Paul J.; Sheppard, Dean
作者单位：University of California System; University of California San Francisco
摘要：Fibroblasts are present throughout the body and function to maintain tissue homeostasis. Recent studies have identified diverse fibroblast subsets in healthy and injured tissues1,2, but the origins and functional roles of injury-induced fibroblast lineages remain unclear. Here we show that lung-specialized alveolar fibroblasts take on multiple molecular states with distinct roles in facilitating responses to fibrotic lung injury. We generate a genetic tool that uniquely targets alveolar fibrob...
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作者：Dadonaite, Bernadeta; Brown, Jack; McMahon, Teagan E.; Farrell, Ariana G.; Figgins, Marlin D.; Asarnow, Daniel; Stewart, Cameron; Lee, Jimin; Logue, Jenni; Bedford, Trevor; Murrell, Ben; Chu, Helen Y.; Veesler, David; Bloom, Jesse D.
作者单位：Fred Hutchinson Cancer Center; Fred Hutchinson Cancer Center; University of Washington; University of Washington Seattle; Fred Hutchinson Cancer Center; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; Karolinska Institutet
摘要：SARS-CoV-2 variants acquire mutations in the spike protein that promote immune evasion1 and affect other properties that contribute to viral fitness, such as ACE2 receptor binding and cell entry2,3. Knowledge of how mutations affect these spike phenotypes can provide insight into the current and potential future evolution of the virus. Here we use pseudovirus deep mutational scanning4 to measure how more than 9,000 mutations across the full XBB.1.5 and BA.2 spikes affect ACE2 binding, cell ent...
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作者：Fisch, Daniel; Zhang, Tian; Sun, He; Ma, Weiyi; Tan, Yunhao; Gygi, Steven P.; Higgins, Darren E.; Kagan, Jonathan C.
作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; University of Virginia; University of Virginia; Harvard University; Harvard Medical School
摘要：Innate immune pattern recognition receptors, such as the Toll-like receptors (TLRs), are key mediators of the immune response to infection and central to our understanding of health and disease1. After microbial detection, these receptors activate inflammatory signal transduction pathways that involve I kappa B kinases, mitogen-activated protein kinases, ubiquitin ligases and other adaptor proteins. The mechanisms that connect the proteins in the TLR pathways are poorly defined. To delineate T...
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作者：Ma, Runze; Zhang, Yan; Zhang, Jing; Zhang, Pinqi; Liu, Zeqi; Fan, Yiming; Wang, Hao-Tian; Zhang, Zhuqiang; Zhu, Bing
作者单位：Chinese Academy of Sciences; Institute of Biophysics, CAS; Chinese Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Chinese Academy of Sciences; Institute of Biophysics, CAS
摘要：Pericentric heterochromatin is a critical component of chromosomes marked by histone H3 K9 (H3K9) methylation1-3. However, what recruits H3K9-specific histone methyltransferases to pericentric regions in vertebrates remains unclear4, as does why pericentric regions in different species share the same H3K9 methylation mark despite lacking highly conserved DNA sequences2,5. Here we show that zinc-finger proteins ZNF512 and ZNF512B specifically localize at pericentric regions through direct DNA b...
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作者：Castelvecchi, Davide
摘要：Hubble Space Telescope point to an elusive intermediate-size black hole in the star cluster omega Centauri.
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作者：Catanzaro, Michele
摘要：Researchers say unexpected victory for Masoud Pezeshkian could spell improvements to human rights, investment in science and academic freedom - if Iran's top leaders give him space to act?
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作者：Hall, Shannon
摘要：Universities and institutions across the globe are exploring unique initiatives to help their students and staff cope with the stress of research.
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作者：[Anonymous]
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作者：Su, Yujuan; Xu, Jinhao; Zhu, Ziai; Chin, Jisun; Xu, Le; Yu, Haoze; Nudell, Victoria; Dash, Barsha; Moya, Esteban A.; Ye, Li; Nimmerjahn, Axel; Sun, Xin
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; Scripps Research Institute; La Jolla Institute for Immunology; University of California System; University of California San Diego; Salk Institute
摘要：Exaggerated airway constriction triggered by repeated exposure to allergen, also called hyperreactivity, is a hallmark of asthma. Whereas vagal sensory neurons are known to function in allergen-induced hyperreactivity(1-3), the identity of downstream nodes remains poorly understood. Here we mapped a full allergen circuit from the lung to the brainstem and back to the lung. Repeated exposure of mice to inhaled allergen activated the nuclei of solitary tract (nTS) neurons in a mast cell-, interl...
