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作者：Neupane, Sujaya; Fiete, Ila; Jazayeri, Mehrdad
作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
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作者：Marsicano, Claudia A.; Pardo, Jason D.; Smith, Roger M. H.; Mancuso, Adriana C.; Gaetano, Leandro C.; Mocke, Helke
作者单位：University of Buenos Aires; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); University of Buenos Aires; Field Museum of Natural History (Chicago); University of Witwatersrand; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
摘要：Current hypotheses of early tetrapod evolution posit close ecological and biogeographic ties to the extensive coal-producing wetlands of the Carboniferous palaeoequator with rapid replacement of archaic tetrapod groups by relatives of modern amniotes and lissamphibians in the late Carboniferous (about 307 million years ago). These hypotheses draw on a tetrapod fossil record that is almost entirely restricted to palaeoequatorial Pangea (Laurussia)1,2. Here we describe a new giant stem tetrapod,...
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作者：Goncalves, Judith; Dixon, Scott J.
作者单位：Stanford University
摘要：An unusual form of cell death called ferroptosis can sweep over embryonic tissues in a wave-like manner to ensure proper muscle development - evidence that ferroptosis has a role in normal physiology.
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作者：Pamer, Eric G.
作者单位：University of Chicago
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作者：Gaertner, Florian; Ishikawa-Ankerhold, Hellen; Stutte, Susanne; Fu, Wenwen; Weitz, Jutta; Dueck, Anne; Nelakuditi, Bhavishya; Fumagalli, Valeria; van den Heuvel, Dominic; Belz, Larissa; Sobirova, Gulnoza; Zhang, Zhe; Titova, Anna; Navarro, Alejandro Martinez; Pekayvaz, Kami; Lorenz, Michael; von Baumgarten, Louisa; Kranich, Jan; Straub, Tobias; Popper, Bastian; Zheden, Vanessa; Kaufmann, Walter Anton; Guo, Chenglong; Piontek, Guido; von Stillfried, Saskia; Boor, Peter; Colonna, Marco; Clauss, Sebastian; Schulz, Christian; Brocker, Thomas; Walzog, Barbara; Scheiermann, Christoph; Aird, William C.; Nerlov, Claus; Stark, Konstantin; Petzold, Tobias; Engelhardt, Stefan; Sixt, Michael; Hauschild, Robert; Rudelius, Martina; Oostendorp, Robert A. J.; Iannacone, Matteo; Heinig, Matthias; Massberg, Steffen
作者单位：University of Munich; Institute of Science & Technology - Austria; German Centre for Cardiovascular Research; Munich Heart Alliance; University of Munich; University of Munich; University of Munich; Technical University of Munich; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Technical University of Munich; Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele; Vita-Salute San Raffaele University; University of Munich; University of Munich; University of Munich; University of Munich; RWTH Aachen University; RWTH Aachen University Hospital; Washington University (WUSTL); University of Geneva; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; University of Oxford; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; German Centre for Cardiovascular Research; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Technical University of Munich
摘要：Platelet homeostasis is essential for vascular integrity and immune defence(1,2). Although the process of platelet formation by fragmenting megakaryocytes (MKs; thrombopoiesis) has been extensively studied, the cellular and molecular mechanisms required to constantly replenish the pool of MKs by their progenitor cells (megakaryopoiesis) remains unclear(3,4). Here we use intravital imaging to track the cellular dynamics of megakaryopoiesis over days. We identify plasmacytoid dendritic cells (pD...
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作者：Sun, Kathie Y.; Bai, Xiaodong; Chen, Siying; Bao, Suying; Zhang, Chuanyi; Kapoor, Manav; Backman, Joshua; Joseph, Tyler; Maxwell, Evan; Mitra, George; Gorovits, Alexander; Mansfield, Adam; Boutkov, Boris; Gokhale, Sujit; Habegger, Lukas; Marcketta, Anthony; Locke, Adam E.; Ganel, Liron; Hawes, Alicia; Kessler, Michael D.; Sharma, Deepika; Staples, Jeffrey; Bovijn, Jonas; Gelfman, Sahar; Di Gioia, Alessandro; Rajagopal, Veera M.; Lopez, Alexander; Varela, Jennifer Rico; Alegre-Diaz, Jesus; Berumen, Jaime; Tapia-Conyer, Roberto; Kuri-Morales, Pablo; Torres, Jason; Emberson, Jonathan; Collins, Rory; Cantor, Michael; Thornton, Timothy; Kang, Hyun Min; Overton, John D.; Shuldiner, Alan R.; Cremona, M. Laura; Nafde, Mona; Baras, Aris; Abecasis, Goncalo; Marchini, Jonathan; Reid, Jeffrey G.; Salerno, William; Balasubramanian, Suganthi
作者单位：Regeneron; Universidad Nacional Autonoma de Mexico; Tecnologico de Monterrey; University of Oxford; University of Oxford
摘要：Rare coding variants that substantially affect function provide insights into the biology of a gene(1-3). However, ascertaining the frequency of such variants requires large sample sizes(4-8). Here we present a catalogue of human protein-coding variation, derived from exome sequencing of 983,578 individuals across diverse populations. In total, 23% of the Regeneron Genetics Center Million Exome (RGC-ME) data come from individuals of African, East Asian, Indigenous American, Middle Eastern and ...
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作者：Roychoudhry, Suruchi; Kepinski, Stefan
作者单位：University of Leeds
摘要：How plants sense their orientation in relation to gravity and steer their root and shoot growth accordingly is not fully understood. The discovery of key steps needed for this process fills in some of the gaps in our knowledge.
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作者：Petridis, Petros D.
摘要：After a person takes the psychedelic compound psilocybin, some of their brain networks dissolve - especially the one involved in the perception of self, space and time. Changes to the connections to this network can last for weeks. Psilocybin induces profound changes in brain connectivity.
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作者：Stankey, C. T.; Bourges, C.; Haag, L. M.; Turner-Stokes, T.; Piedade, A. P.; Palmer-Jones, C.; Papa, I.; dos Santos, M. Silva; Zhang, Q.; Cameron, A. J.; Legrini, A.; Zhang, T.; Wood, C. S.; New, F. N.; Randzavola, L. O.; Speidel, L.; Brown, A. C.; Hall, A.; Saffioti, F.; Parkes, E. C.; Edwards, W.; Direskeneli, H.; Grayson, P. C.; Jiang, L.; Merkel, P. A.; Saruhan-Direskeneli, G.; Sawalha, A. H.; Tombetti, E.; Quaglia, A.; Thorburn, D.; Knight, J. C.; Rochford, A. P.; Murray, C. D.; Divakar, P.; Green, M.; Nye, E.; MacRae, J. I.; Jamieson, N. B.; Skoglund, P.; Cader, M. Z.; Wallace, C.; Thomas, D. C.; Lee, J. C.
作者单位：Francis Crick Institute; Imperial College London; Washington University (WUSTL); Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; University of London; University College London; UCL Medical School; Royal Free London NHS Foundation Trust; University of London; University College London; Francis Crick Institute; Wellcome Trust Sanger Institute; University of Glasgow; NanoString Technologies; Francis Crick Institute; University of London; University College London; University of Oxford; Wellcome Centre for Human Genetics; University of London; University College London; Royal Free London NHS Foundation Trust; UCL Medical School; University of London; University College London; UCL Medical School; Royal Free London NHS Foundation Trust; University of Cambridge; Marmara University; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS); Fudan University; University of Pennsylvania; University of Pennsylvania; Istanbul University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Milan; University of London; University College London; University of Oxford; Francis Crick Institute; University of Cambridge; University of Cambridge; MRC Biostatistics Unit
摘要：Increasing rates of autoimmune and inflammatory disease present a burgeoning threat to human health(1). This is compounded by the limited efficacy of available treatments(1) and high failure rates during drug development(2), highlighting an urgent need to better understand disease mechanisms. Here we show how functional genomics could address this challenge. By investigating an intergenic haplotype on chr21q22-which has been independently linked to inflammatory bowel disease, ankylosing spondy...
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作者：Callaway, Ewen
摘要：The cave-dwelling group hunted animals such as hyenas and hares to sustain themselves in harsh environments.
