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作者：O'Brien, Evan S.; Rangari, Vipin Ashok; El Daibani, Amal; Eans, Shainnel O.; Hammond, Haylee R.; White, Elizabeth; Wang, Haoqing; Shiimura, Yuki; Kumar, Kaavya Krishna; Jiang, Qianru; Appourchaux, Kevin; Huang, Weijiao; Zhang, Chensong; Kennedy, Brandon J.; Mathiesen, Jesper M.; Che, Tao; McLaughlin, Jay P.; Majumdar, Susruta; Kobilka, Brian K.
作者单位：Stanford University; University of Health Sciences & Pharmacy in St. Louis; Washington University (WUSTL); State University System of Florida; University of Florida; Kurume University; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Princeton University; University of Copenhagen
摘要：The mu -opioid receptor (mu OR) is a well-established target for analgesia1, yet conventional opioid receptor agonists cause serious adverse effects, notably addiction and respiratory depression. These factors have contributed to the current opioid overdose epidemic driven by fentanyl2, a highly potent synthetic opioid. mu OR negative allosteric modulators (NAMs) may serve as useful tools in preventing opioid overdose deaths, but promising chemical scaffolds remain elusive. Here we screened a ...
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作者：Kozlov, Max
摘要：Older populations might be more protected than younger ones because of exposure to 'matched' strains during childhood, but an H5N1 pandemic is likely to take a major toll all the same.
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作者：Chen, Hengxing; Li, Yun; Li, Huafu; Chen, Xiancong; Fu, Huafeng; Mao, Deli; Chen, Wei; Lan, Linxiang; Wang, Chunming; Hu, Kaishun; Li, Jia; Zhu, Chengming; Evans, Ian; Cheung, Eddie; Lu, Daning; He, Yulong; Behrens, Axel; Yin, Dong; Zhang, Changhua
作者单位：Sun Yat Sen University; Sun Yat Sen University; University of London; Institute of Cancer Research - UK; Royal Marsden NHS Foundation Trust; Sun Yat Sen University; Sun Yat Sen University; State Key Lab Oncology South China
摘要：The Warburg effect is a hallmark of cancer that refers to the preference of cancer cells to metabolize glucose anaerobically rather than aerobically1,2. This results in substantial accumulation of lacate, the end product of anaerobic glycolysis, in cancer cells3. However, how cancer metabolism affects chemotherapy response and DNA repair in general remains incompletely understood. Here we report that lactate-driven lactylation of NBS1 promotes homologous recombination (HR)-mediated DNA repair....
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作者：Tanigaki, Toshiaki; Akashi, Tetsuya; Yoshida, Takaho; Harada, Ken; Ishizuka, Kazuo; Ichimura, Masahiko; Mitsuishi, Kazutaka; Tomioka, Yasuhide; Yu, Xiuzhen; Shindo, Daisuke; Tokura, Yoshinori; Murakami, Yasukazu; Shinada, Hiroyuki
作者单位：Hitachi Limited; RIKEN; National Institute for Materials Science; National Institute of Advanced Industrial Science & Technology (AIST); Tohoku University; University of Tokyo; University of Tokyo; Kyushu University
摘要：Atomic-scale observations of a specific local area would be considerably beneficial when exploring new fundamental materials and devices. The development of hardware-type aberration correction1,2 in electron microscopy has enabled local structural observations with atomic resolution3-5 as well as chemical and vibration analysis6-8. In magnetic imaging, however, atomic-level spin configurations are analysed by electron energy-loss spectroscopy by placing samples in strong magnetic fields9-11, w...
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作者：Bianco, Simona; Hasan, Muhammad; Ahmad, Ashfaq; Richards, Sarah-Jane; Dietrich, Bart; Wallace, Matthew; Tang, Qiao; Smith, Andrew J.; Gibson, Matthew I.; Adams, Dave J.
作者单位：University of Glasgow; University of Warwick; University of Warwick; University of Manchester; University of East Anglia; Diamond Light Source; University of Manchester
摘要：A long-standing challenge is how to formulate proteins and vaccines to retain function during storage and transport and to remove the burdens of cold-chain management. Any solution must be practical to use, with the protein being released or applied using clinically relevant triggers. Advanced biologic therapies are distributed cold, using substantial energy, limiting equitable distribution in low-resource countries and placing responsibility on the user for correct storage and handling. Cold-...
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作者：Bourzac, Katherine
摘要：Researchers analysed thousands of laboratory-made plasmids and discovered that nearly half of them had defects, raising questions of experimental reproducibility.
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作者：Cahill, Catherine M.
作者单位：University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
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作者：Harlow, Evelyn Mwesigwa; Adair, Jennifer E.
作者单位：Ministry of Health - Uganda; Fred Hutchinson Cancer Center
摘要：Gene therapies will become more affordable everywhere only if they are developed and produced in the regions where they are most needed.
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作者：Yu, Haoxuan
作者单位：University of Cambridge
摘要：From weakening jet streams to causing bumpier flights, climate change is altering atmospheric behaviour. Researchers need to find out how.
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作者：Baltgalvis, Kristen A.; Lamb, Kelsey N.; Symons, Kent T.; Wu, Chu-Chiao; Hoffman, Melissa A.; Snead, Aaron N.; Song, Xiaodan; Glaza, Thomas; Kikuchi, Shota; Green, Jason C.; Rogness, Donald C.; Lam, Betty; Rodriguez-Aguirre, Maria E.; Woody, David R.; Eissler, Christie L.; Rodiles, Socorro; Negron, Seth M.; Bernard, Steffen M.; Tran, Eileen; Pollock, Jonathan; Tabatabaei, Ali; Contreras, Victor; Williams, Heather N.; Pastuszka, Martha K.; Sigler, John J.; Pettazzoni, Piergiorgio; Rudolph, Markus G.; Classen, Moritz; Brugger, Doris; Claiborne, Christopher; Plancher, Jean-Marc; Cuartas, Isabel; Seoane, Joan; Burgess, Laurence E.; Abraham, Robert T.; Weinstein, David S.; Simon, Gabriel M.; Patricelli, Matthew P.; Kinsella, Todd M.
