Nature

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• Geology's biggest mystery: when did plate tectonics start to reshape Earth? AI翻译
  作者：Marshall, Michael
  摘要：Researchers have spent decades hunting for clues about the origins of the process that moves the continents around. Its deep history is finally starting to come into focus.
• SECOND BRAIN IMPLANT BY ELON MUSK'S NEURALINK: WILL IT FARE BETTER THAN THE FIRST? AI翻译
  作者：Naddaf, Miryam; Drew, Liam
  摘要：Device allowing the user to control a computer cursor using their thoughts has been adjusted in a bid to prevent glitches with the first implant.
• Structure of the human dopamine transporter in complex with cocaine AI翻译
  作者：Nielsen, Jeppe C.; Salomon, Kristine; Kalenderoglou, Iris E.; Bargmeyer, Sarah; Pape, Tillmann; Shahsavar, Azadeh; Loland, Claus J.
  作者单位：University of Copenhagen; Novo Nordisk Foundation; University of Copenhagen; University of Copenhagen; University of Copenhagen
  摘要：The dopamine transporter (DAT) is crucial for regulating dopamine signalling and is the prime mediator for the rewarding and addictive effects of cocaine(1). As part of the neurotransmitter sodium symporter family, DAT uses the Na+ gradient across cell membranes to transport dopamine against its chemical gradient(2). The transport mechanism involves both intra- and extracellular gates that control substrate access to a central site. However, the molecular intricacies of this process and the in...
• Membrane prewetting by condensates promotes tight-junction belt formation AI翻译
  作者：Pombo-Garcia, Karina; Adame-Arana, Omar; Martin-Lemaitre, Cecilie; Juelicher, Frank; Honigmann, Alf
  作者单位：Max Planck Society; Max Planck Society; Technische Universitat Dresden; Technische Universitat Dresden; Rosalind Franklin Institute
  摘要：Biomolecular condensates enable cell compartmentalization by acting as membraneless organelles(1). How cells control the interactions of condensates with other cellular structures such as membranes to drive morphological transitions remains poorly understood. We discovered that formation of a tight-junction belt, which is essential for sealing epithelial tissues, is driven by a wetting phenomenon that promotes the growth of a condensed ZO-1 layer(2) around the apical membrane interface. Using ...
• A hike of postdoc salary alone will not retain the best researchers in low- or middle-income countries AI翻译
  作者：Bayry, Jagadeesh
  作者单位：Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Palakkad
• Turbinate-homing IgA-secreting cells originate in the nasal lymphoid tissues AI翻译
  作者：Liu, Jingjing; Stoler-Barak, Liat; Hezroni-Bravyi, Hadas; Biram, Adi; Lebon, Sacha; Davidzohn, Natalia; Kedmi, Merav; Chemle, Muriel; Pilzer, David; Cohen, Marina; Brenner, Ori; Biton, Moshe; Shulman, Ziv
  作者单位：Weizmann Institute of Science; Weizmann Institute of Science; Weizmann Institute of Science; Weizmann Institute of Science; Weizmann Institute of Science
  摘要：Nasal vaccination elicits a humoral immune response that provides protection from airborne pathogens(1), yet the origins and specific immune niches of antigen-specific IgA-secreting cells in the upper airways are unclear(2). Here we define nasal glandular acinar structures and the turbinates as immunological niches that recruit IgA-secreting plasma cells from the nasal-associated lymphoid tissues (NALTs)(3). Using intact organ imaging, we demonstrate that nasal vaccination induces B cell expan...
• Dismantle 'zombie' wildlife protection conventions once their work is done AI翻译
  作者：Bridgewater, Peter; Kim, Rakhyun E.; Blasiak, Robert; Sellheim, Nikolas
  作者单位：Australian National University; Utrecht University; Stockholm University
  摘要：Almost 80 years after it was created, the international whaling convention has outlived its usefulness. Ending it could set an example for other organizations.
• These AI firms publish the world's most highly cited work AI翻译
  作者：Gibney, Elizabeth
  摘要：US and Chinese firms dominate the list of companies that are producing the most research and patents in artificial intelligence.
• Structures of the dopamine transporter point to ways to target addiction and disease AI翻译
  作者：Sitte, Harald H.
  作者单位：Medical University of Vienna
  摘要：Three studies of the human dopamine transporter reveal how it binds to molecules such as dopamine and cocaine. Dopamine imbalances underlie some brain conditions and these data will aid targeted drug design.
• Unimolecular net heterolysis of symmetric and homopolar σ-bonds AI翻译
  作者：Tiefel, Anna F.; Grenda, Daniel J.; Allacher, Carina; Harrer, Elias; Nagel, Carolin H.; Kutta, Roger J.; Hernandez-Castillo, David; Narasimhamurthy, Poorva R.; Zeitler, Kirsten; Gonzalez, Leticia; Rehbein, Julia; Nuernberger, Patrick; Breder, Alexander
  作者单位：University of Regensburg; University of Regensburg; University of Vienna; University of Vienna; Leipzig University; University of Vienna; University of Regensburg
  摘要：The unimolecular heterolysis of covalent sigma-bonds is integral to many chemical transformations, including S(N)1-, E1- and 1,2-migration reactions. To a first approximation, the unequal redistribution of electron density during bond heterolysis is governed by the difference in polarity of the two departing bonding partners(1-3). This means that if a sigma-bond consists of two identical groups (that is, symmetric sigma-bonds), its unimolecular fission from the S-0, S-1, or T-1 states only occ...