Structures of the dopamine transporter point to ways to target addiction and disease

• 成果类型: Editorial Material
• 署名作者: Sitte, Harald H.
• 署名单位: Medical University of Vienna
• 刊物名称: Nature
• ISSN/ISSBN: 0028-6130
• DOI: 10.1038/d41586-024-02435-0
• 发表日期: 2024-08-15
• 页码: 509-511
• 关键词: neurotransmitter transporters; binding; drugs

摘要

Three studies of the human dopamine transporter reveal how it binds to molecules such as dopamine and cocaine. Dopamine imbalances underlie some brain conditions and these data will aid targeted drug design.