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作者:Chapman, Michael Spencer; Wilk, C. Matthias; Boettcher, Steffen; Mitchell, Emily; Dawson, Kevin; Williams, Nicholas; Muller, Jan; Kovtonyuk, Larisa; Jung, Hyunchul; Caiado, Francisco; Roberts, Kirsty; O'Neill, Laura; Kent, David G.; Green, Anthony R.; Nangalia, Jyoti; Manz, Markus G.; Campbell, Peter J.
作者单位:Wellcome Trust Sanger Institute; University of Cambridge; University of Zurich; University of Zurich; University Zurich Hospital; University of York - UK
摘要:Allogeneic haematopoietic cell transplantation (HCT) replaces the stem cells responsible for blood production with those from a donor(1,2). Here, to quantify dynamics of long-term stem cell engraftment, we sequenced genomes from 2,824 single-cell-derived haematopoietic colonies of ten donor-recipient pairs taken 9-31 years after HLA-matched sibling HCT3. With younger donors (18-47 years at transplant), 5,000-30,000 stem cells had engrafted and were still contributing to haematopoiesis at the t...
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作者:Liu, Peng; Huang, Mei-Ling; Guo, Hua; Mccallum, Matthew; Si, Jun-Yu; Chen, Yuan-Mei; Wang, Chun-Li; Yu, Xiao; Shi, Lu-Lu; Xiong, Qing; Ma, Cheng-Bao; Bowen, John E.; Tong, Fei; Liu, Chen; Sun, Ye-hui; Yang, Xiao; Chen, Jing; Guo, Ming; Li, Jing; Corti, Davide; Veesler, David; Shi, Zheng-Li; Yan, Huan
作者单位:Wuhan University; Chinese Academy of Sciences; Wuhan Institute of Virology, CAS; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle; Guangzhou Laboratory
摘要:Although coronaviruses use diverse receptors, the characterization of coronaviruses with unknown receptors has been impeded by a lack of infection models1,2. Here we introduce a strategy to engineer functional customized viral receptors (CVRs). The modular design relies on building artificial receptor scaffolds comprising various modules and generating specific virus-binding domains. We identify key factors for CVRs to functionally mimic native receptors by facilitating spike proteolytic cleav...
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作者:Falk, Francesca
作者单位:University of Bern
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作者:Money, Nicholas P.
作者单位:University System of Ohio; Miami University
摘要:A mesmerizing global tour will make readers question what they think they know about mushrooms.
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作者:Guatelli-Steinberg, Debbie
作者单位:University System of Ohio; Ohio State University
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作者:Zollikofer, Christoph P. E.; Beyrand, Vincent; Lordkipanidze, David; Tafforeau, Paul; Ponce de Leon, Marcia S.
作者单位:University of Zurich; Institute for Basic Science - Korea (IBS); European Synchrotron Radiation Facility (ESRF); Ivane Javakhishvili Tbilisi State University
摘要:Human life history is characterized by an extended period of immaturity during which there is a disjunction between cerebral and somatic growth rates1. This mode of ontogeny is thought to be essential for the acquisition of advanced cognitive capabilities in a socially complex environment while the brain is still growing2. Key information about when and how this pattern evolved can be gleaned from the teeth of fossil hominins because dental development informs about the pace of life history3-5...
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作者:Haider, Nadia
作者单位:Delft University of Technology
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作者:Glotzer, Sharon C.
作者单位:University of Michigan System; University of Michigan
摘要:In 1984, scientists made a crystalline alloy that had a seemingly impossible arrangement of atoms. They had discovered the first quasicrystal - a type of material that transformed ideas about how atoms can be ordered in solids.
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作者:[Anonymous]
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作者:Wang, Yurui; Lin, Renxing; Liu, Chenshuaiyu; Wang, Xiaoyu; Chosy, Cullen; Haruta, Yuki; Bui, Anh Dinh; Li, Minghui; Sun, Hongfei; Zheng, Xuntian; Luo, Haowen; Wu, Pu; Gao, Han; Sun, Wenjie; Nie, Yuefeng; Zhu, Hesheng; Zhou, Kun; Nguyen, Hieu T.; Luo, Xin; Li, Ludong; Xiao, Chuanxiao; Saidaminov, Makhsud I.; Stranks, Samuel D.; Zhang, Lijun; Tan, Hairen
作者单位:Nanjing University; Jilin University; University of Cambridge; University of Cambridge; University of Victoria; Australian National University; Chinese Academy of Sciences; Ningbo Institute of Materials Technology & Engineering, CAS
摘要:The fabrication of scalable all-perovskite tandem solar cells is considered an attractive route to commercialize perovskite photovoltaic modules1. However, the certified efficiency of 1-cm2-scale all-perovskite tandem solar cells lags behind their small-area (approximately 0.05-cm2) counterparts2,3. This performance deficit originates from inhomogeneity in wide-bandgap (WBG) perovskite solar cells (PSCs) at a large scale. The inhomogeneity is known to be introduced at the bottom interface and ...