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• Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin AI翻译
  作者：Turner, Adrianna M.; Li, Lucy; Monk, Ian R.; Lee, Jean Y. H.; Ingle, Danielle J.; Portelli, Stephanie; Sherry, Norelle L.; Isles, Nicole; Seemann, Torsten; Sharkey, Liam K.; Walsh, Calum J.; Reid, Gavin E.; Nie, Shuai; Eijkelkamp, Bart A.; Holmes, Natasha E.; Collis, Brennan; Vogrin, Sara; Hiergeist, Andreas; Weber, Daniela; Gessner, Andre; Holler, Ernst; Ascher, David B.; Duchene, Sebastian; Scott, Nichollas E.; Stinear, Timothy P.; Kwong, Jason C.; Gorrie, Claire L.; Howden, Benjamin P.; Carter, Glen P.
  作者单位：University of Melbourne; Peter Doherty Institute; Monash Health; University of Queensland; University of Melbourne; Peter Doherty Institute; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; University of Melbourne; University of Melbourne; University of Melbourne; University of Melbourne; University of Melbourne; Flinders University South Australia; University of Melbourne; Peter Doherty Institute; University of Melbourne; University of Regensburg; University of Regensburg; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris
  摘要：Multidrug-resistant bacterial pathogens like vancomycin-resistant Enterococcus faecium (VREfm) are a critical threat to human health1. Daptomycin is a last-resort antibiotic for VREfm infections with a novel mode of action2, but for which resistance has been widely reported but is unexplained. Here we show that rifaximin, an unrelated antibiotic used prophylactically to prevent hepatic encephalopathy in patients with liver disease3, causes cross-resistance to daptomycin in VREfm. Amino acid ch...
• Let the data talk: embrace exploratory research AI翻译
  作者：Aczel, Balazs
  作者单位：Eotvos Lorand University
  摘要：Open-ended research is essential to building solid hypotheses in the social sciences - without it, even the best-planned analyses can fail.
• End 'disability bias' in grant awards AI翻译
  作者：Qi, Fei
  作者单位：Hainan University
• Efficient green InP-based QD-LED by controlling electron injection and leakage AI翻译
  作者：Bian, Yangyang; Yan, Xiaohan; Chen, Fei; Li, Qian; Li, Bo; Hou, Wenjun; Lu, Zizhe; Wang, Shuaibing; Zhang, Han; Zhang, Wenjing; Zhang, Dandan; Tang, Aiwei; Fan, Fengjia; Shen, Huaibin
  作者单位：Henan University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Hefei National Laboratory; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Beijing Jiaotong University; TCL Inc.
  摘要：Green indium phosphide (InP)-based quantum dot light-emitting diodes (QD-LEDs) still suffer from low efficiency and short operational lifetime, posing a critical challenge to fully cadmium-free QD-LED displays and lighting1-3. Unfortunately, the factors that underlie these limitations remain unclear and, therefore, no clear device-engineering guidelines are available. Here, by using electrically excited transient absorption spectroscopy, we find that the low efficiency of state-of-the-art gree...
• Major biomedical funder NIH poised for massive reform under Trump 2.0 AI翻译
  作者：Kozlov, Max
  摘要：Sweeping changes and more research scrutiny could be on the way for the US National Institutes of Health.
• New schizophrenia drug could treat Alzheimer's disease AI翻译
  作者：Kwon, Diana
  摘要：Half a dozen drugs are in trials for conditions of the brain, but success is not guaranteed.
• Act now to stop millions of research papers from disappearing AI翻译
  作者：Vandekar, Simon
• In the big data era, prioritize statistical significance in study design AI翻译
  作者：[Anonymous]
  摘要：Analysis of neuroimaging studies shows that close attention to experimental design can increase the statistical robustness of research results.
• NK2R control of energy expenditure and feeding to treat metabolic diseases AI翻译
  作者：Sass, Frederike; Ma, Tao; Ekberg, Jeppe H.; Kirigiti, Melissa; Urena, Mario G.; Dollet, Lucile; Brown, Jenny M.; Basse, Astrid L.; Yacawych, Warren T.; Burm, Hayley B.; Andersen, Mette K.; Nielsen, Thomas S.; Tomlinson, Abigail J.; Dmytiyeva, Oksana; Christensen, Dan P.; Bader, Lindsay; Vo, Camilla T.; Wang, Yaxu; Rausch, Dylan M.; Kristensen, Cecilie K.; Gestal-Mato, Maria; Panhuis, Wietse In Het; Sjoberg, Kim A.; Kernodle, Stace; Petersen, Jacob E.; Pavlovskyi, Artem; Sandhu, Manbir; Moltke, Ida; Jorgensen, Marit E.; Albrechtsen, Anders; Grarup, Niels; Babu, M. Madan; Rensen, Patrick C. N.; Kooijman, Sander; Seeley, Randy J.; Worthmann, Anna; Heeren, Joerg; Pers, Tune H.; Hansen, Torben; Gustafsson, Magnus B. F.; Tang-Christensen, Mads; Kilpelainen, Tuomas O.; Myers Jr, Martin G.; Kievit, Paul; Schwartz, Thue W.; Hansen, Jakob B.; Gerhart-Hines, Zachary
  作者单位：University of Copenhagen; University of Southern Denmark; Oregon Health & Science University; Oregon National Primate Research Center; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; St Jude Children's Research Hospital; Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC); Leiden University; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC; University of Michigan System; University of Michigan; University of Copenhagen; Steno Diabetes Center; University of Copenhagen; Copenhagen University Hospital; University of Southern Denmark; University of Hamburg; University Medical Center Hamburg-Eppendorf; Monash University
  摘要：The combination of decreasing food intake and increasing energy expenditure represents a powerful strategy for counteracting cardiometabolic diseases such as obesity and type 2 diabetes1. Yet current pharmacological approaches require conjugation of multiple receptor agonists to achieve both effects2-4, and so far, no safe energy-expending option has reached the clinic. Here we show that activation of neurokinin 2 receptor (NK2R) is sufficient to suppress appetite centrally and increase energy...
• Coherent growth of high-Miller-index facets enhances perovskite solar cells AI翻译
  作者：Li, Shunde; Xiao, Yun; Su, Rui; Xu, Weidong; Luo, Deying; Huang, Pengru; Dai, Linjie; Chen, Peng; Caprioglio, Pietro; Elmestekawy, Karim A.; Dubajic, Milos; Chosy, Cullen; Hu, Juntao; Habib, Irfan; Dasgupta, Akash; Guo, Dengyang; Boeije, Yorrick; Zelewski, Szymon J.; Lu, Zhangyuchang; Huang, Tianyu; Li, Qiuyang; Wang, Jingmin; Yan, Haoming; Chen, Hao-Hsin; Li, Chunsheng; Lewis, Barnaby A. I.; Wang, Dengke; Wu, Jiang; Zhao, Lichen; Han, Bing; Wang, Jianpu; Herz, Laura M.; Durrant, James R.; Novoselov, Kostya S.; Lu, Zheng-Hong; Gong, Qihuang; Stranks, Samuel D.; Snaith, Henry J.; Zhu, Rui
  作者单位：Peking University; Peking University; Tsinghua University; Collaborative Innovation Center of Quantum Matter; University of Oxford; University of Cambridge; University of Cambridge; Beihang University; National University of Singapore; Institute for Functional Intelligent Materials (I-FIM); Yunnan University; Wroclaw University of Science & Technology; Nanjing Tech University; Nanjing Tech University; Peking University; Eastern Institute of Technology, Ningbo; Eastern Institute for Advanced Study; Changzhou University; Changzhou University; Imperial College London; Imperial College London; Swansea University; University of Toronto; Shanxi University
  摘要：Obtaining micron-thick perovskite films of high quality is key to realizing efficient and stable positive (p)-intrinsic (i)-negative (n) perovskite solar cells1,2, but it remains a challenge. Here we report an effective method for producing high-quality, micron-thick formamidinium-based perovskite films by forming coherent grain boundaries, in which high-Miller-index-oriented grains grow on the low-Miller-index-oriented grains in a stabilized atmosphere. The resulting micron-thick perovskite f...